Results 71 to 80 of about 18,095,855 (237)

Recent Advances in High‐Entropy Nanozymes: From Fabrication to Applications

Advanced Science, EarlyView.
To highlight key achievements and clarify the current landscape of high‐entropy nanozymes (HEAzymes), this review summarizes state‐of‐the‐art developments ranging from thermodynamically and kinetically controlled synthetic strategies; enzyme‐like catalytic types, catalytic characteristics, and underlying mechanisms; to their antioxidative, therapeutic,
Yongjian Ai, Weibo Zhang, Pengjie Wang, Wentao Xu, Huiyuan Guo, Hong‐bin Sun, Meng‐Qi He, Fazheng Ren, Qionglin Liang   +8 more
wiley   +1 more source

Quantitative SPECT/CT imaging of actinium-225 for targeted alpha therapy of glioblastomas

EJNMMI Physics
Background A new, alternative option for patients with recurrent glioblastoma is targeted alpha therapy (TAT), in the form of a local administration of substance P (neurokinin type 1 receptor ligand, NK-1) labelled with 225Ac.
Monika Tulik, Radosław Kuliński, Zbisław Tabor, Beata Brzozowska, Piotr Łaba, Frank Bruchertseifer, Alfred Morgenstern, Leszek Królicki, Jolanta Kunikowska   +8 more
doaj   +1 more source

Astatine-211 and actinium-225: two promising nuclides in targeted alpha therapy

Acta Biochimica et Biophysica Sinica
Nuclear medicine therapy offers a promising approach for tumor treatment, as the energy emitted during radionuclide decay causes irreparable damage to tumor cells. Notably, α-decay exhibits an even more significant destructive potential. By conjugating α-
Zuo Dashan, Wang Hui, Yu Boyi, Li Qiang, Gan Lu, Chen Weiqiang   +5 more
doaj   +1 more source

Deciphering Electrochemical Generation, Transport, and Reactivity of Hydrogen Species in the Electrochemical Palladium Membrane Reactor

Advanced Science, EarlyView.
This study elucidates hydrogen transport and reaction mechanisms in ePMR using 1‐hexyne hydrogenation as a model reaction. Hydrogen transport operates via dual pathways involving hydrogen atom permeation and H2‐mediated re‐dissociation on secondary metal layers.
Samuel J. Shin, Su Bin Roh, Hyun‐Tak Kim, Kwan‐Young Lee, Soo Min Kim, Ji Hoon Park, Minju Park   +6 more
wiley   +1 more source

Site‐Specific Protein Bioconjugation Through Cellular Incorporation of Noncanonical Amino Acids

Angewandte Chemie, EarlyView.
Genetic code expansion (GCE) enables site‐specific installation of noncanonical amino acids containing bioorthogonal conjugation handles, allowing precise, homogeneous protein modification. This review examines the principles of orthogonal translation, surveys the chemistries available for chemoselective labeling, and highlights emerging multi‐site ...
Rahul Sarkar, Manas Joshi, Abhishek Chatterjee   +2 more
wiley   +2 more sources

A Monte Carlo Method for Determining the Response Relationship between Two Commonly Used Detectors to Indirectly Measure Alpha Particle Radiation Activity

Molecules, 2019
Using targeted ligands to deliver alpha-emitting radionuclides directly to tumor cells has become a promising therapeutic strategy. To calculate the radiation dose to patients, activities of parent and daughter radionuclides must be measured ...
Christopher J. Tichacek, Mikalai M. Budzevich, Thaddeus J. Wadas, David L. Morse, Eduardo G. Moros   +4 more
doaj   +1 more source

Comparative Evaluation of Chelator‐Conjugated Peptides for Lead‐Labeled SSTR2‐Targeted Theranostics: Integrated Computational Modeling and Preclinical Validation

Advanced Science, EarlyView.
The study integrates density functional theory with radiochemical and biological validation to compare DOTA‐, PSC‐, and DOTAM‐based chelator‐conjugates for 203Pb/212Pb theranostic applications. Distinct differences in metal coordination, electrostatic properties, conformational flexibility, cellular uptake, biodistribution, and dosimetry are identified
Jeongyun Kim, Na Yeon Han, Ayman Muzammal, Jae Hun Ahn, Changkeun Im, Sujin Kim, Sairan Eom, Choong Mo Kang, Ku Kang, Yong Jin Lee, Kyo Chul Lee, Michael K. Schultz, Dongyoul Lee   +12 more
wiley   +1 more source

The Separation of Bismuth-213 from Actinium-225 and the Ion Exchange Properties of the Alkali Metal Cations with an Inorganic Resin [PDF]

, 2017
Interest in the use of alpha radiation emitters in radio immunotherapy is due to the high linear energy transfer and short range of alpha radiation.
Moore, Mark Alan
core  

Advances in Josephson Junction Materials and Processes Toward Practical Quantum Computing

Advanced Science, EarlyView.
Emerging materials for quantum computing, including crystalline materials, two‐dimensional van der Waals materials, two‐dimensional electron gas systems, ferromagnets, and unconventional (e.g., d‐wave) superconductors, offer opportunities to engineer next‐generation Josephson junctions.
Hyunseong Kim, Gyunghyun Jang, Seungwon Jin, Jaewon An, Dongbin Shin, Hyeon‐Jin Shin, Jie Luo, Akel Hashim, Irfan Siddiqi, Yosep Kim, Long B. Nguyen, Hoon Hahn Yoon   +11 more
wiley   +1 more source

Exploratory case series of circulating tumor DNA dynamics during tandem therapy in metastatic castration-resistant prostate cancer

EJNMMI Research
Background Prostate-specific membrane antigen (PSMA)-targeted radiopharmaceutical therapy (RPT) with the alpha-emitter actinium-225 (225Ac) has shown promising activity in metastatic castration-resistant prostate cancer (mCRPC), but its use is limited by
Mariam Amghar, Tobias Rausch, Hilal Özgür, Mareike Roscher, Ulrike Bauder-Wüst, Frank Bruchertseifer, Alfred Morgenstern, Vladimír Beneš, Clemens Kratochwil, Martina Benešová-Schäfer   +9 more
doaj   +1 more source