Results 131 to 140 of about 14,232,320 (254)

ALKBH3 m1A Demethylase Deficiency Reduces Alzheimer's Amyloid‐β Pathology

Advanced Science, Volume 13, Issue 32, 9 June 2026.
This study identifies that ALKBH3‐driven m1A demethylation orchestrates Alzheimer's disease progression by disrupting mitochondrial and synaptic homeostasis. This epitranscriptomic mechanism suppresses PINK1‐mediated mitophagy via m1A erasure, leading to mitochondrial dysfunction, oxidative stress, elevated Aβ production, and impaired microglial ...
Yueyang Li, Sifei Yu, Kaidong Lu, Yujie Zhang, Mingjie Dong, Yan Peng, Liang Xue, Waleed Alam, Yuxuan Shui, Yi Zhou, Wuyunhan Ma, Meng Bao, Peiming Li, Peiyi Luo, Tiezhan Lu, Jiajia Li, Kang Zhang, Yuying Wang, Shuchen Yang, Nuoya Yin, Francesco Faiola, Zilong Gao, Jingfeng Zhou, Fei Zhao, Yali He, Magdalena J. Koziol   +25 more
wiley   +1 more source

ETV4 Improves Cerebral Ischemia‐Reperfusion Injury by Restraining YBX1‐GPX4‐Ferroptosis Cascades

Brain and Behavior, Volume 16, Issue 6, June 2026.
ABSTRACT Background Cerebral ischemia‐reperfusion injury (CIRI) is a critical pathological process following ischemic stroke, with ferroptosis being increasingly recognized as a key contributor to neuronal damage. However, the regulatory mechanisms, particularly the role of specific transcription factors like E26 transformation‐specific variant 4 (ETV4)
Qian Xu, Faming Deng, Dan Yu
wiley   +1 more source

Embryonal Paratesticular Rhabdomyosarcoma Masquerading as an Inguinal Hernia: A Case Report

Clinical Case Reports, Volume 14, Issue 6, June 2026.
ABSTRACT Embryonal paratesticular rhabdomyosarcoma can mimic benign inguinoscrotal conditions such as inguinal hernia. In children with persistent, painless scrotal masses, early cross‐sectional imaging and prompt radical inguinal orchiectomy with histopathological confirmation are essential.
Somaya Al Kiswani, Qusai Otoum, Morad Abbas, Momen Sawafta, Abdallateef salih, Omar Jaber, Azza Gharaibeh, Abdullah Nofal   +7 more
wiley   +1 more source

Actinomycin D downregulates Sox2 and improves survival in preclinical models of recurrent glioblastoma. [PDF]

Neuro Oncol, 2020
Taylor JT, Ellison S, Pandele A, Wood S, Nathan E, Forte G, Parker H, Zindy E, Elvin M, Dickson A, Williams KJ, Karabatsou K, McCabe M, McBain C, Bigger BW.   +14 more
europepmc   +1 more source

TRMT10C promotes mitochondrial fission through transferrin receptor m1A methylation modification and aggravates the progression of atrial fibrillation

Journal of Cell Communication and Signaling, Volume 20, Issue 2, June 2026.
TRMT10C promotes mitochondrial dynamics imbalance (excessive fission) by regulating TFRC m1A methylation modification, induces myocardial fibrosis, and exacerbates the progression of AF. Abstract Atrial fibrillation (AF) is a common cardiac arrhythmia often accompanied by structural remodeling of the atria, particularly fibrosis, and disruption of ...
Nijina Li, Hao Zhang
wiley   +1 more source

Stepwise transcription stalling by the anti-cancer drug Actinomycin D and insights into short tandem repeat transcription inhibition. [PDF]

Nat Commun
Zhao W, Zhu L, Liu Y, Deng W, Yang X, Ye L, Lin Z, Ding K, Yang X, Li X, Xu J.   +10 more
europepmc   +1 more source

Actinomycin D Arrests Cell Cycle of Hepatocellular Carcinoma Cell Lines and Induces p53-Dependent Cell Death: A Study of the Molecular Mechanism Involved in the Protective Effect of IRS-4. [PDF]

Pharmaceuticals (Basel), 2021
Guijarro LG, Sanmartin-Salinas P, Pérez-Cuevas E, Toledo-Lobo MV, Monserrat J, Zoullas S, Sáez MA, Álvarez-Mon MA, Bujan J, Noguerales-Fraguas F, Arilla-Ferreiro E, Álvarez-Mon M, Ortega MA.   +12 more
europepmc   +1 more source

Myeloid HDAC7 drives liver inflammation and systemic glucose dysregulation during diet‐induced obesity

Clinical &Translational Immunology, Volume 15, Issue 6, 2026.
This study explored the role of the class IIa histone deacetylase HDAC7 in hepatic inflammation and metabolic disease. Genetic approaches in mice revealed that myeloid HDAC7 drives hepatic inflammation and gene signatures associated with advanced chronic liver disease.
Yizhuo Wang, Divya Ramnath, Kaustav Das Gupta, P Prakrithi, Kavita Bisht, Gregory C Miller, Zherui Xiong, Yujun Wan, Ellen N Tejo, James EB Curson, Rishika Abrol, Sahar Keshvari, Kimberley S Gunther, Jordan D Atkinson, Zhixuan Loh, Jessica A Engel, Christian R Engwerda, Sabrina Sofia Burgener, Kate Schroder, David P Fairlie, Andrew D Clouston, Elizabeth E Powell, Katharine M Irvine, Mitchell A Sullivan, Jean‐Pierre Lévesque, Quan Nguyen, Matthew J Sweet, Denuja Karunakaran   +27 more
wiley   +1 more source

Structural Characterisation of TetR/AcrR Regulators in <i>Streptomyces fildesensis</i> So13.3: An In Silico CRISPR-Based Strategy to Influence the Suppression of Actinomycin D Production. [PDF]

Int J Mol Sci
Leal K, Machuca J, Gajardo H, Palma M, Contreras MJ, Nuñez-Montero K, Gutiérrez Á, Barrientos L.   +7 more
europepmc   +1 more source

HSP70 regulates cell proliferation and apoptosis in actinomycin-D-treated lung cancer cells. [PDF]

Transl Cancer Res, 2020
Zhang K, Zhai R, Xue T, Xu X, Ren Y, Ma M, Shi F, Wang H, Wang N, Zhou F.   +9 more
europepmc   +1 more source