Results 111 to 120 of about 14,232,320 (254)

Actinomycin D

Biophysical Journal, 1969
Bacchetti, S., Whitmore, G.F.
openaire   +1 more source

The Fate (Outcome) of Clinically Apparent Single Lesion and Oligofocal Nephroblastomatosis Treated According to SIOP/GPOH Protocols for Wilms Tumor

Pediatric Blood &Cancer, Volume 73, Issue 7, July 2026.
ABSTRACT Background The management of clinically apparent single lesions or oligofocal nephroblastomatosis, a facultative precursor of nephroblastoma, remains debated. Methods We retrospectively analyzed 37 patients with clinically apparent single or oligofocal nephroblastomatosis (two to three lesions per kidney) among 2347 patients registered between
Nils Welter, Jens‐Peter Schenk, Jenny Wegert, Manfred Gessler, Leo Kager, Stefan Wagenpfeil, Marina Müller, Jean‐Michel Wolff, Joerg Fuchs, Steven W. Warmann, Clemens‐Magnus Meier, Jochen Hubertus, Christian Rübe, Christian Vokuhl, Patrick Melchior, Lena Tschirner, Norbert Graf, Rhoikos Furtwängler   +17 more
wiley   +1 more source

A living biobank of sarcoma patient‐derived cell cultures reveals multi‐omic and functional insights that capture disease heterogeneity

Clinical and Translational Medicine, Volume 16, Issue 7, July 2026.
Preclinical models for sarcoma that preserve tumour biology are urgently needed to advance mechanistic understanding and functional precision oncology. 29 early‐passage patient‐derived sarcoma cell (PDC) cultures from 19 patients, representing 11 sarcoma subtypes were established and extensively characterized.
Stefanie Gijsels, Suzanne Fischer, David Creytens, Sándor Dedeyne, Felix De Vuyst, Cláudio Pinheiro, Fleur Cordier, Sarah‐Lee Bekaert, Nadine Van Roy, Kaat Durinck, Jarne Pauwels, Kris Gevaert, Pieter Mestdagh, Jo Vandesompele, Pekka Rappu, Jyrki Heino, An Hendrix, Gabrielle H. van Ramshorst, Gwen Sys, Olivier De Wever   +19 more
wiley   +1 more source

Results with Floxuridine, Actinomycin D, Etoposide, and Vincristine in Gestational Trophoblastic Neoplasias with International Federation of Gynecology and Obstetrics Scores ≥5. [PDF]

Oncologist, 2021
Li Y, Kong Y, Wan X, Feng F, Ren T, Zhao J, Yang J, Xiang Y.   +7 more
europepmc   +1 more source

Mex‐3 RNA‐binding family member A limits macrophage ferroptosis‐associated injury linked to the SLC7A11/GPX4 pathway in diabetic atherosclerosis

Clinical and Translational Medicine, Volume 16, Issue 7, July 2026.
Diabetes reduces macrophage MEX3A and aggravates atherosclerotic plaque instability. MEX3A stabilises Slc7a11 and Gpx4 mRNAs to sustain SLC7A11/GPX4 antioxidant defence. MEX3A deficiency promotes macrophage ferroptosis, lipid peroxidation and mitochondrial injury. Ferrostatin‐1 partially attenuates ferroptotic injury and diabetic plaque destabilisation.
Yanpeng Ma, Jing Liu, Yujie Xing, Shuo Pan, Begench H. Annayev, We Wu, Xiqiang Wang, Zhongwei Liu   +7 more
wiley   +1 more source

The actinomycin D molecule docks to a hydrophilic section of the SOX2 high-mobility group (HMG) domain. [PDF]

Neuro Oncol, 2021
Lehrer S, Rheinstein PH.
europepmc   +1 more source

A Primate‐Specific lncRNA LINC01021 Contributes to Cellular and Organismal Aging via DAZAP1‐Dependent Destabilization of RBMX

Aging Cell, Volume 25, Issue 7, July 2026.
Primate‐specific lncRNA LINC01021 promotes aging by enhancing cellular senescence and accelerating aspects of organismal decline. Mechanistically, LINC01021 induces DAZAP1‐mediated destabilization of RBMX, activating the P53 pathway and establishing a primate‐specific regulatory axis in aging.
Yan Zhang, Li Hu, Xin Dong, Qinghua Zeng, Meiting Zi, Ayesha Nisar, Sawar Khan, Raoxian Bai, Chonghui Liu, Mingxia Ge, Shaoyan Pu, Gonghua Li, Yonghan He   +12 more
wiley   +1 more source

Mobility of Nucleostemin in Live Cells Is Specifically Related to Transcription Inhibition by Actinomycin D and GTP-Binding Motif. [PDF]

Int J Mol Sci, 2021
Pack CG, Jung K, Paulson B, Kim JK.
europepmc   +1 more source

Benzbromarone as a Novel Candidate for Preventing Alzheimer's Disease: Evidence From Real‐World Data Screening and in Vitro Validation

Clinical and Translational Science, Volume 19, Issue 7, July 2026.
Drug repositioning analysis identifies candidate therapeutic agents for Alzheimer’s diseaseand supports further mechanistic and translational investigation. ABSTRACT Drug development for Alzheimer's disease (AD) remains challenging, with only a 0.4% success rate from Phase I trials to regulatory approval.
Sho Sakagami, Yuya Yoshida, Shota Uemura, Taisei Kumamoto, Ryotaro Tsukamoto, Takumi Nishi, Shimpei Kawano, Kohei Fukuoka, Hanami Ino, Kengo Hamamura, Shigehiro Ohdo, Naoya Matsunaga   +11 more
wiley   +1 more source

Investigating the Impact of Carboxylated Polystyrene Nanoplastics in the Liver Using Cell Lines and Precision‐Cut Liver Slices

Liver International, Volume 46, Issue 7, July 2026.
ABSTRACT Background and Aims Increasing reports of plastic accumulation in human tissue have raised concerns about potential adverse health outcomes. Evidence of negative effects of nanoplastics is heterogeneous and provides limited insights into the underlying pathogenic toxicity mechanisms in humans. Methods In the present study, carboxylate‐modified
Namrata Pandey, Paula Boeira, Nathaniel J. Clark, Eleanor T. Walker, Somaiah Aroori, Jemimah Denson, Richard C. Thompson, Matthew E. Cramp, Shilpa Chokshi, Ashwin Dhanda   +9 more
wiley   +1 more source