Results 181 to 190 of about 14,232,320 (254)

ABCB1 (C1236T) Polymorphism Affects P-Glycoprotein-Mediated Transport of Methotrexate, Doxorubicin, Actinomycin D, and Etoposide

DNA and Cell Biology, 2019
P-glycoprotein (P-gp), encoded by the ABCB1 (ATP-binding cassette transporter superfamily B member 1) gene, is a transport protein involved in the efflux and distribution of the osteosarcoma drugs methotrexate, doxorubicin, actinomycin D, and etoposide ...
Bo Jiang, Li-jun Yan, Qian Wu
semanticscholar   +1 more source

A phenazine analog of actinomycin D

Journal of Medicinal Chemistry, 1979
An analogue of actinomycin D (1), in which the phenoxazone chromophore has been replaced by a phenazine, has been synthesized and characterized. Although this compound (2) lacks the 2-amino group and does not possess the quinoid structure of 1, it does bind to DNA, but less tightly than either 1 or the 2-deamino derivative of 1.
C W, Mosher, D Y, Lee, R M, Enanoza, P A, Sturm, K F, Kuhlmann   +4 more
openaire   +2 more sources

The interaction of actinomycin D and radiation

International Journal of Radiation Oncology*Biology*Physics, 1978
The interaction of actinomycin D and radiation are reviewed and particularly the use of this combination in Wilms' tumours. The toxic effects of the combination on vital organs is stressed and preliminary results from laboratory experiments aimed at answering the toxicity problems of the combination are given.
D, Pearson, D P, Deakin, J H, Hendry, J V, Moore   +3 more
openaire   +2 more sources

Folliculitis Induced by Actinomycin D

New England Journal of Medicine, 1969
Abstract In nine of 11 adult patients treated with actinomycin D a characteristic skin eruption developed, with predictable progression from erythema to papules and pustules and from face to trunk. The dominant histologic feature of these lesions was initial replacement of the hair follicles and sebaceous glands with neutrophils.
E H, Epstein, M A, Lutzner
openaire   +2 more sources

Effects of Actinomycin D on Morphogenesis

Nature, 1963
THE possible role in morphogenesis of ribonucleic acids (RNA) produced by the cell nuclei (presumably ‘messenger’ RNA's) has been discussed recently by one of us1. In short, it was suggested that, in a relatively simple system such as the regenerating unicellular alga Acetabularia, the ‘morphogenetic substances’ of Hammerling2 could be equated to ...
Brachet, Jean, Denis, Hélène
openaire   +3 more sources

The effect of actinomycin D on cancer in childhood.

Pediatrics, 1959
Actinomycin D has a slight but definite effect in producing regression of tumors in patients with cancer. Wilms' tumor and lymphomas have shown better response than other tumors.
Charlotte T. C. Tan, H. Dargeon, J. Burchenal   +2 more
semanticscholar   +1 more source

Actinomycin D and the Response to Vitamin D

Science, 1965
The administration of low doses of actinomycin D to rachitic chicks inhibits the action of a subsequent dose of vitamin D 3 in promoting calcium absorption from the intestine.
openaire   +2 more sources

Solvent Effect on the Conformation of Actinomycin D

Nature, 1970
THERE have been several different approaches to the stereochemistry of the interaction of actinomycin and DNA, including studies of the interaction of DNA-like polynucleotides with actinomycin1,2, and of DNA with model compounds related to actinomycin3–5, using various experimental techniques.
F. Ascoli, DE SANTIS, Pasquale, SAVINO, Maria   +2 more
openaire   +3 more sources

Actinomycin D Inhibition of Vitamin D Action

Science, 1965
Injection of actinomycin D into rats completely prevents both the rise in serum calcium normally induced by vitamin D and the increased transport of calcium by everted intestinal sacs. Injection of excess parathyroid hormone did not alter this result; this eliminates the possibility that the inhibition of vitamin action was due to blocked hormone ...
J E, Zull, E, Czarnowska-Misztal, H F, Deluca   +2 more
openaire   +2 more sources

Actinomycin D: a novel Pseudomonasaeruginosa quorum sensing inhibitor from the endophyte Streptomycescyaneochromogenes RC1

World Journal of Microbiology & Biotechnology, 2022
Yue-Xiang Zeng, J. Liu, Ying-jie Wang, Shiueh-Jung Tang, Dayong Wang, Shi-Ming Deng, Ai-Qun Jia   +6 more
semanticscholar   +1 more source