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Suppression of erythropoiesis by actinomycin D. I. Evolutional change of hemopoiesis by actinomycin D

open access: yesSuppression of erythropoiesis by actinomycin D. I. Evolutional change of hemopoiesis by actinomycin D
For the purpose of revealing whether the sensitivity of the erythropoiesis to actinomycin D (AMD) differs among different animal species, and to see the acting site of AMD on erythroid cell specialization stage, the author observed the hourly change of the blood cell counts and bone marrow cells after AMD administration to mice, rats and rabbits, and ...
openaire  

Actinomycin D and Telmisartan Combination Targets Lung Cancer Stem Cells Through the Wnt/Beta Catenin Pathway. [PDF]

open access: yesSci Rep, 2019
Green R   +11 more
europepmc   +1 more source

Development of a physiologically based pharmacokinetic model of actinomycin D in children with cancer

open access: yesBritish Journal of Clinical Pharmacology, 2016
Aims Use of the anti‐tumour antibiotic actinomycin D is associated with development of hepatotoxicity, particularly in young children. A paucity of actinomycin D pharmacokinetic data make it challenging to develop a sound rationale for defining dosing ...
Christopher Walsh   +2 more
exaly   +2 more sources
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Conformation of Actinomycin-D

Nature, 1970
NUCLEAR magnetic resonance (NMR) spectroscopy has recently been found useful for investigating the conformations of polypeptides like gramicidin S1,2, valinomicin3 and so on. We now report preliminary conclusions on the conformation of the two peptide lactone rings of actinomycin D4 on the basis of NMR results and theoretical conformational analysis ...
CONTI, Filippo, DE SANTIS, Pasquale
openaire   +3 more sources

Crystal Structures of Actinomycin D and Actinomycin Z3

Angewandte Chemie International Edition, 1998
Untwinned single crystals of the actinomycins D and Z3 that diffracted to atomic resolution could be obtained for the first time. Low-temperature data collection and a new ab initio method for solving the structures led to precise crystal structures which showed, for example, that the unit cell of actinomycin D contains three molecules, two of which ...
Martina, Schäfer   +3 more
openaire   +2 more sources

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