Results 191 to 200 of about 14,232,320 (254)

Inhibition of Ovulation in the Rabbit by Actinomycin D

Nature, 1964
IN the rabbit, an induced ovulator, sufficient gonadotropin is released in the first hour after coitus to result in ovulation 9 h later1. This represents an interesting example of a stimulus-response system. Although the stimulus pathway has been reasonably elucidated, the response is not well understood. The subsequent steps in the response beyond the
W R, POOL, H, LIPNER
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Inhibition of trans-synaptically increased tyrosine hydroxylase activity by cycloheximide and actinomycin D.

Molecular Pharmacology, 1969
Reserpine produces a neurally mediated increase in tyrosine hydroxylase activity in the adrenal medullae and sympathetic ganglia of the rat. This increase in enzyme activity can be prevented by the administration of actinomycin D or cycloheximide.
Robert A. Mueller, Hans Thoenen, Julius Axelrod   +2 more
semanticscholar   +1 more source

The Effect of Actinomycin D on Childhood Neoplasms

Archives of Pediatrics & Adolescent Medicine, 1960
Actinomycin D is an antibiotic which was isolated from cultures of Streptomyces parvallus by Manaker et al., 1 in 1954. In 1957, Bullock and Johnson 2 elucidated the structure of this compound (Fig. 1). Actinomycin D has been shown to inhibit bacterial growth, 3-5 to produce cytotoxic changes in tissue cultures of neoplastic cells, 6 and to have ...
R K, SHAW, E W, MOORE, P S, MUELLER, E, FREI, D M, WATKIN   +4 more
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Actinomycin D and RNA transport

Nature, 1974
ACTINOMYCIN D, a potent inhibitor of RNA chain propagation of DNA-directed RNA transcription1–3, has been widely used for studies of turnover and transport of RNA in a variety of cell systems, to try to demonstrate that nuclear RNA labelled before the addition of actinomycin D is transported to the cytoplasm.
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Kristallstrukturen von Actinomycin D und Actinomycin Z3

Angewandte Chemie, 1998
Unverzwillingte, bis zu atomarer Auflosung streuende Einkristalle konnten erstmals von den Actinomycinen D und Z3 erhalten werden. Tieftemperaturmessungen und die Nutzung neuer Ab-initio-Strukturlosungsmethoden lieferten prazise Kristallstrukturen und ergaben, das z. B.
Martina Schäfer, George M. Sheldrick, Isabel Bahner, Helmut Lackner   +3 more
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Actinomycin D and the Response to Parathyroid Hormone

Science, 1964
Actinomycin D inhibits the effect of parathyroid hormone upon bone, as measured by calcium mobilization, without altering its effects upon the renal excretion of phosphate and calcium.
H, RASMUSSEN, C, ARNAUD, C, HAWKER
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Measurement of Antitumour Activity of Actinomycin D

Nature, 1971
SEVERAL antibiotics are being used as antitumour agents because of their cytotoxic activity against both proliferating and non-proliferating cells1 but the doses of the substances given to patients are largely judged by empirical observations. Clearly it would be more satisfactory if the antitumour activity could be measured in the laboratory.
Curtis, K, Perkins, F T
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Actinomycin D: Effect on the Immune Response

Science, 1964
Actinomycin D injected simultaneously with sheep erythrocytes in female rats caused a delay in the immune response but had no effect on the rate or maximum amount of hemagglutinin produced. The delay was roughly proportional to the concentration of the antibiotic administered, and was up to 2 days for 75 μg in a 200-gram female rat (sublethal dose for ...
C J, WUST, C L, GALL, D G, NOVELLI
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Mechanism of intestinal radiosensitization by actinomycin D

The British Journal of Radiology, 1973
Abstract The interaction between actinomycin D (Act D) and X-irradiation on the mouse jejunum was examined. The two principal actions of the drug were to: (1) inhibit repair of sublethal radiation damage as evidenced by a reduction in shoulder width of the crypt survival curve and by lack of repair between divided exposures ; and, (2) delay the onset ...
R F, Hagemann, J P, Concannon
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Prevention of cerebral vasospasm by actinomycin D

Journal of Neurosurgery, 1991
✓ The role of endothelin, a newly found vasoconstrictor peptide, is examined in the pathogenesis of cerebral vasospasm after experimental subarachnoid hemorrhage (SAH) in the dog. Endothelin immunoreactivity was overexpressed in the endothelium of the vasospastic basilar artery.
Taku Shigeno, Tatsuo Mima, Masashi Yanagisawa, Akira Saito, Katsutoshi Goto, Kazumasa Yamashita, Toshiharu Takenochi, Naosuke Matsuura, Yasuhide Yamasaki, Koji Yamada, Tomoh Masaki, Kimitomo Takakura   +11 more
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