Results 111 to 120 of about 26,423 (304)

Leiomyosarcoma of the Inferior Venacava: A Case Report

Journal of Nepal Medical Association, 2019
Leiomyosarcoma of inferior venacava is a rare tumor. Female are most commonly affected and middle segment of inferior vena cava is the commonest site. The diagnosis can sometimes be challenging as patients present with non-specific symptoms. We present a
Diksha Karki, Paricha Upadhayaya, Purbesh Adhikari, Mona Dahal, Bishow Prakash Jung Thapa, Bandana Mudbhari, Gopal Lama, Neera Pathak   +7 more
doaj   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Transfected muscle and non-muscle actins are differentially sorted by cultured smooth muscle and non-muscle cells

, 1997
We have analyzed by immunolabeling the fate of exogenous epitope-tagged actin isoforms introduced into cultured smooth muscle and non-muscle (i.e. endothelial and epithelial) cells by transfecting the corresponding cDNAs in transient expression assays ...
Mounier, N., Chaponnier, Christine, Gabbiani, Giulio, Perriard, J. C.   +3 more
core  

An. gambiae actins display tissue, developmental-specific, and immune-responsive expression.

, 2015
Transcript abundance of all An. gambiae actin genes in the (A) thorax, abdomen, and midgut adult tissues or (B) at distinct developmental stages compared to the adult female mosquito and normalized using the An. gambiae ribosomal S7 gene. Actin 5C (651 A,
Andrew Pike (689657), Simone L. Sandiford (689656), George Dimopoulos (17514), Ana C. Bahia (159531), Yuemei Dong (17509), Benjamin J. Blumberg (453329)   +5 more
core   +1 more source

The elusive actin cytoskeleton of a green alga expressing both conventional and divergent actins [PDF]

, 2019
The green alga Chlamydomonas reinhardtii is a leading model system to study photosynthesis, cilia, and the generation of biological products. The cytoskeleton plays important roles in all of these cellular processes, but to date, the filamentous actin ...
Engel, B., Avasthi, Prachee, Craig, E., Mueller, D., Bigge, B., Avasthi, P., Engel, Benjamin D., Mueller, David M., Schaffer, Miroslava, Schaffer, M., Craig, Evan W., Bigge, Brae M.   +11 more
core   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Atomic view into Plasmodium actin polymerization, ATP hydrolysis, and fragmentation.

PLoS Biology, 2019
Plasmodium actins form very short filaments and have a noncanonical link between ATP hydrolysis and polymerization. Long filaments are detrimental to the parasites, but the structural factors constraining Plasmodium microfilament lengths have remained ...
Esa-Pekka Kumpula, Andrea J Lopez, Leila Tajedin, Huijong Han, Inari Kursula   +4 more
doaj   +1 more source

Multiple essential functions of Plasmodium falciparum actin-1 during malaria blood-stage development

BMC Biology, 2017
Background The phylum Apicomplexa includes intracellular parasites causing immense global disease burden, the deadliest of them being the human malaria parasite Plasmodium falciparum, which invades and replicates within erythrocytes.
Sujaan Das, Leandro Lemgruber, Chwen L. Tay, Jake Baum, Markus Meissner   +4 more
doaj   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Cell cultures of human ciliary muscle: growth, ultrastructural and immunocytochemical characteristics

, 1991
Primary ciliary muscle cell cultures derived from human donors (16-91 years) were established and characterized by comparing them with ciliary muscle in tissue sections using immunocytochemical and ultrastructural methods.
Baur, A., Tamm, Ernst R., Flügel, C., Lütjen-Drecoll, E.   +3 more
core   +1 more source