Results 81 to 90 of about 77,276 (354)
Forbidden Synonymous Substitutions in Coding Regions [PDF]
, 1993 In the evolution of highly conserved genes, a few "synonymous" substitutions at third bases that would not alter the protein sequence are forbidden or very rare, presumably as a result of functional requirements of the gene or the messenger RNA.
Britten, Roy J.
core
Actin, actin-binding proteins, and actin-related proteins in the nucleus [PDF]
Histochemistry and Cell Biology, 2016 Extensive research in the past decade has significantly broadened our view about the role actin plays in the life of the cell and added novel aspects to actin research. One of these new aspects is the discovery of the existence of nuclear actin which became evident only recently.
Kristó, Ildikó +4 more
openaire +3 more sources
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
Dipotassium 4,4′-(hexane-3,4-diyl)bis(benzenesulfonate) dihydrate
Acta Crystallographica Section E, 2008 The anion of the title compound, also called sygethin dihydrate, 2K+·C18H20O6S22−·2H2O, has crystallographic inversion symmetry. The K+ cation is surrounded by eight O atoms in a distorted cubic coordination geometry, forming extended K ...
Liana Orola +3 more
doaj +1 more source
シロイヌナズナアクチンアイソフォームの分子細胞生物学的研究 [PDF]
, 2018 この博士論文は内容の要約のみの公開（または一部非公開）になっています筑波大学 (University of Tsukuba ...
KIJIMA Saku, 貴嶋 紗久
core +1 more source
The Anatomical Record, 2018 ABSTRACTMicroridges are highly distinctive “fingerprint”‐patterned structures situated on the outer surface of superficial layer cells of the epithelium. An F‐actin‐based cytoskeleton is the underlying core structural component of microridges. The basis for much of what is known about microridges has been provided by in vivo and in vitro fish ...
openaire +2 more sources
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
Nature Communications, 2018 In the mdx mouse model of Duchenne muscular dystrophy, muscle contractions lead to force loss, which is attributed to myofibre damage. Here, the authors show that force loss is instead mediated by a redox circuit involving NOX2, PROX1, myoglobin and ...
John T. Olthoff +11 more
doaj +1 more source
Rapid production of pure recombinant actin isoforms in Pichia pastoris [PDF]
, 2018 Actins are major eukaryotic cytoskeletal proteins, which perform many important cell functions, including cell division, cell polarity, wound healing, and muscle contraction.
Alioto, Salvatore +15 more
core +1 more source
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source