Results 241 to 250 of about 982,671 (310)

Team-based primary care without collaboration: a call for academic partnerships in relational transformation. [PDF]

Front Med (Lausanne)
McLellan A, Odugleh-Kolev A, Wright V, Binch J.   +3 more
europepmc   +1 more source

Potent and Selective IGF‐IIR‐Recruiting Bifunctional Molecules for Targeted Lysosomal Degradation of Extracellular and Membrane Proteins

Advanced Science, EarlyView.
Lysosome‐targeting chimeras (LYTACs) enable degradation of extracellular and membrane proteins via lysosomal trafficking. We report a novel IGF‐II mutant (Del1–7, Y27L) that selectively engages IGF‐IIR while avoiding IGF‐IR and IR‐A. mutIGF‐II–based LYTACs enhance target internalization and degradation and support a genetically encodable, all‐protein ...
Yuan Zhao, Yaxian Liao, Pengyun Li, Regina Stasser de Gonzalez, Xuankun Chen, Nicholas S. Nieto, Florence M. Brunel, Nick Cox, Joseph Stock, Matthew McHenry, Guangsen Fu, Penghsuan Huang, Wenxin Wu, Deqin Cai, Lingjun Li, Alexander N. Zaykov, Weiping Tang   +16 more
wiley   +1 more source

EU Foreign, Security and Defence Policy: A Competence-Responsibility Gap? [PDF]

, 2013
Hertogh, L. den, Wessel, R.A.
core   +1 more source

Adolescence in crisis: Insights from the 2024 ESPAD report and a nursing perspective. [PDF]

iScience
Ferreira Díaz MJ.
europepmc   +1 more source

SMAD4 Palmitoylation Drives a Metabolic‐Transcriptional Circuit to Promote Tumorigenesis and Confers Radiosensitivity in Pancreatic Cancer

Advanced Science, EarlyView.
This study identifies palmitoylation as a novel regulatory modification of SMAD4, mediated by ZDHHC22/APT2. It activates fatty acid synthesis, creating a self‐reinforcing SMAD4–FASN–palmitate feedback loop that drives pancreatic cancer growth and enhances radiotherapy sensitivity.
Yang Wang, Shan Zhang, Junping Bai, Xiaobing Li, Yi Han, Min Ji, Chongyi Jiang, Xiaobei Ge, Tianyu Yu, Yongying Hou, Jun Zhang, Wangting Li, Yiran Song, Jiaying Cai, Yingqun Zhou, Liwei An, Feng Wang   +16 more
wiley   +1 more source

Bridging health literacy and physical literacy for sustainable health. [PDF]

Front Public Health
Eriksson C, Hedlund J, Harder M, Almqvist L, Borglund L.   +4 more
europepmc   +1 more source

A Metal‐Free Carbon Monoxide Prodrug Suppresses Metastasis of Pancreatic and Breast Cancer

Advanced Science, EarlyView.
A metal‐free carbon monoxide (CO) prodrug, CO‐116, delivers controlled systemic CO without inhalation. CO suppresses the HRG1–heme axis, reducing intracellular heme availability. Attenuation of this pathway inhibits metastatic progression in pancreatic and triple‐negative breast cancer models.
Tiantian Zhang, Xiang Chen, Xiaoxiao Yang, Muskan Gori, Rohit Kumar Varshnaya, Dongning Liu, Cheryl Zhang, Michelle Yi Qin Chen, Zhengming Chen, George Zhang, Erika Patel, Qiyue Mao, Tan A. Ince, Chalet Tan, Binghe Wang, Yi‐Chieh Nancy Du   +15 more
wiley   +1 more source

How doctors move from generic goals to specific communicative behaviour in real practice communications [PDF]

, 2011
Elwyn, G., Mogendorff, K., Ram, P.M., Veldhuijzen, W., Weijden, T., v.d.   +4 more
core   +1 more source

Professional intercultural communicative competence in action

Innovation in Language Learning and Teaching
Stefanie Schneider, Müge Satar, Mei Lin, Elaine Lopez   +3 more
openaire   +2 more sources

Moral development in personal and professional identity formation: Longitudinal impact of teaching the role of medicine during the Holocaust in health professions education. [PDF]

GMS J Med Educ
Wald HS, Riesen MS, Kiessling C.
europepmc   +1 more source