Results 11 to 20 of about 1,814,108 (154)

Emerging Roles of the Membrane Potential: Action Beyond the Action Potential

open access: yesFrontiers in Physiology, 2018
Whilst the phenomenon of an electrical resting membrane potential (RMP) is a central tenet of biology, it is nearly always discussed as a phenomenon that facilitates the propagation of action potentials in excitable tissue, muscle, and nerve. However, as
Lina Abdul Kadir   +2 more
doaj   +1 more source

A Quantum-Like Model of Information Processing in the Brain

open access: yesApplied Sciences, 2020
We present the quantum-like model of information processing by the brain’s neural networks. The model does not refer to genuine quantum processes in the brain.
Andrei Khrennikov, Masanari Asano
doaj   +1 more source

Hypochlorite-Modified LDL Induces Arrhythmia and Contractile Dysfunction in Cardiomyocytes

open access: yesAntioxidants, 2021
Neutrophil-derived myeloperoxidase (MPO) and its potent oxidant, hypochlorous acid (HOCl), gained attention as important oxidative mediators in cardiac damage and dysfunction.
Chintan N. Koyani   +10 more
doaj   +1 more source

Altered contractility in mutation-specific hypertrophic cardiomyopathy: A mechano-energetic in silico study with pharmacological insights

open access: yesFrontiers in Physiology, 2022
Introduction: Mavacamten (MAVA), Blebbistatin (BLEB), and Omecamtiv mecarbil (OM) are promising drugs directly targeting sarcomere dynamics, with demonstrated efficacy against hypertrophic cardiomyopathy (HCM) in (pre)clinical trials.
Mohamadamin Forouzandehmehr   +3 more
doaj   +1 more source

Essential oil composition and antinociceptive activity of Thymus capitatus

open access: yesPharmaceutical Biology, 2017
Context: The essential oil (EO) from Thymus capitatus Hoff. et Link. (Lamiaceae) has been traditionally used for its medicinal properties, such as anti-inflammatory, analgesic, antioxidant and antimicrobial properties.
Juan Carlos Ramos Gonçalves   +7 more
doaj   +1 more source

The effect of myocardial action potential duration on cardiac pumping efficacy: a computational study

open access: yesBioMedical Engineering OnLine, 2018
Background and aims Although studies on the relation between arrhythmias and the action potential duration (APD) have been carried out, most of them are based only on electrophysiological factors of the heart and lack experiments that consider cardiac ...
Da Un Jeong, Ki Moo Lim
doaj   +1 more source

Regional and temporal progression of atrial remodeling in angiotensin II mediated atrial fibrillation

open access: yesFrontiers in Physiology, 2022
Atrial fibrillation (AF) is associated with electrical and structural remodeling in the atria; however, the regional and temporal progression of atrial remodeling is incompletely understood. The objective of this study was to investigate the regional and
Hailey J. Jansen   +3 more
doaj   +1 more source

Comparative analysis of the cardiomyocyte differentiation potential of induced pluripotent stem cells reprogrammed from human atrial or ventricular fibroblasts

open access: yesFrontiers in Bioengineering and Biotechnology, 2023
Background: We had shown that cardiomyocytes (CMs) were more efficiently differentiated from human induced pluripotent stem cells (hiPSCs) when the hiPSCs were reprogrammed from cardiac fibroblasts rather than dermal fibroblasts or blood mononuclear ...
Lu Wang   +8 more
doaj   +1 more source

Large-Scale Mapping of Axonal Arbors Using High-Density Microelectrode Arrays

open access: yesFrontiers in Cellular Neuroscience, 2019
Understanding the role of axons in neuronal information processing is a fundamental task in neuroscience. Over the last years, sophisticated patch-clamp investigations have provided unexpected and exciting data on axonal phenomena and functioning, but ...
Torsten Bullmann   +10 more
doaj   +1 more source

Neurocomputational mechanisms underlying perception and sentience in the neocortex

open access: yesFrontiers in Computational Neuroscience
The basis for computation in the brain is the quantum threshold of “soliton,” which accompanies the ion changes of the action potential, and the refractory membrane at convergences.
Andrew S. Johnson   +2 more
doaj   +1 more source

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