Results 21 to 30 of about 1,814,108 (154)

Ionic and Electrotonic Contributions to Short-Term Ventricular Action Potential Memory: An In Silico Study

Computation
Electrical restitution (ER) is a determinant of cardiac repolarization stability and can be measured as steady action potential (AP) duration (APD) at different pacing rates—the so-called dynamic restitution (ERdyn) curve—or as APD changes after pre- or ...
Massimiliano Zaniboni
doaj   +1 more source

Physiological synaptic signals initiate sequential spikes at soma of cortical pyramidal neurons

Molecular Brain, 2011
The neurons in the brain produce sequential spikes as the digital codes whose various patterns manage well-organized cognitions and behaviors. A source for the physiologically integrated synaptic signals to initiate digital spikes remains unknown, which ...
Ge Rongjing, Qian Hao, Wang Jin-Hui
doaj   +1 more source

Heterogeneity of ventricular action potentials in neonatal rat cardiomyocytes and methodological aspects of patch clamp measurements

Frontiers in Physiology
Measurement of the ventricular action potential (AP) via whole-cell patch clamp is an important contributor to cardiac electrophysiological research. Neonatal rat ventricular cardiomyocytes (NRVCM) are a commonly used model, in particular for stressor ...
Pascal Syren, Pascal Syren, Pascal Syren, Anna Zlatopolskaia, Anna Zlatopolskaia, Anna Zlatopolskaia, Claus Bruehl, Axel Schöffel, Axel Schöffel, Axel Schöffel, Teresa Caspari, Teresa Caspari, Teresa Caspari, Chiara Heß, Chiara Heß, Chiara Heß, Norbert Frey, Norbert Frey, Norbert Frey, Dierk Thomas, Dierk Thomas, Dierk Thomas, Patrick Lugenbiel, Patrick Lugenbiel, Patrick Lugenbiel   +24 more
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Synchrony and neural coding in cerebellar circuits

Frontiers in Neural Circuits, 2012
The cerebellum regulates complex movements and is also implicated in cognitive tasks, and cerebellar dysfunction is consequently associated not only with movement disorders, but also with conditions like autism and dyslexia. How information is encoded by
Abigail L Person, Indira M Raman
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Modulation of Ion Channels in the Superior Cervical Ganglion Neurons by Myocardial Ischemia and Fluvastatin Treatment

Frontiers in Physiology, 2018
Background: The superior cervical ganglion (SCG) of the autonomic nervous system plays an important role in different cardiovascular diseases.
Lijun Cheng, Xinghua Wang, Tong Liu, Gary Tse, Gary Tse, Huaying Fu, Guangping Li   +6 more
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Electrophysiological Characterization of Human Atria: The Understated Role of Temperature

Frontiers in Physiology, 2021
Ambient temperature has a profound influence on cellular electrophysiology through direct control over the gating mechanisms of different ion channels. In the heart, low temperature is known to favor prolongation of the action potential.
Rupamanjari Majumder, Rupamanjari Majumder, Afnan Nabizath Mohamed Nazer, Alexander V. Panfilov, Alexander V. Panfilov, Alexander V. Panfilov, Eberhard Bodenschatz, Eberhard Bodenschatz, Eberhard Bodenschatz, Yong Wang, Yong Wang   +10 more
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The Long Journey from Animal Electricity to the Discovery of Ion Channels and the Modelling of the Human Brain

Biomolecules
This retrospective begins with Galvani’s experiments on frogs at the end of the 18th century and his discovery of ‘animal electricity’. It goes on to illustrate the numerous contributions to the field of physical chemistry in the second half of the 19th ...
Luigi Catacuzzeno, Antonio Michelucci, Fabio Franciolini   +2 more
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Effects of Acute Hypernatremia on the Electrophysiology of Single Human Ventricular Cardiomyocytes: An In Silico Study

Reviews in Cardiovascular Medicine
Background: Clinical and experimental data on the cardiac effects of acute hypernatremia are scarce and inconsistent. We aimed to determine and understand the effects of different levels of acute hypernatremia on the human ventricular action potential ...
Arie O. Verkerk, Ronald Wilders
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Motor cortex analogue neurons in songbirds utilize Kv3 channels to generate ultranarrow spikes

eLife, 2023
Complex motor skills in vertebrates require specialized upper motor neurons with precise action potential (AP) firing. To examine how diverse populations of upper motor neurons subserve distinct functions and the specific repertoire of ion channels ...
Benjamin M Zemel, Alexander A Nevue, Leonardo ES Tavares, Andre Dagostin, Peter V Lovell, Dezhe Z Jin, Claudio V Mello, Henrique von Gersdorff   +7 more
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Fully Wireless Implantable Device Capable of Multichannel Neural Spike Recording and Stimulation for Long-Term Freely Moving Rodent Study

IEEE Transactions on Neural Systems and Rehabilitation Engineering
Neural spike recordings provide detailed insights into the neuronal activity and serve as powerful feedback signals for closed-loop neuromodulation, which is gaining significant attention as a medical technology of the future.
Minh Duc Hoang, Wonok Kang, Matthew Koh, Sung-Min Park   +3 more
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