Results 31 to 40 of about 20,440,250 (309)

Overexpression of mGluR7 in the Prefrontal Cortex Attenuates Autistic Behaviors in Mice

Frontiers in Cellular Neuroscience, 2021
Autism spectrum disorder (ASD) is associated with a range of abnormalities pertaining to socialization, communication, repetitive behaviors, and restricted interests. Owing to its complexity, the etiology of ASD remains incompletely understood.
Xiaona Wang, Chao Gao, Yaodong Zhang, Shunan Hu, Yidan Qiao, Zhengqin Zhao, Lingshan Gou, Jijun Song, Qi Wang   +8 more
doaj   +1 more source

Three-dimensional mapping and regulation of action potential propagation in nanoelectronics innervated tissues

Nature Nanotechnology, 2016
Real-time mapping and manipulation of electrophysiology in three-dimensional (3D) tissues could impact broadly fundamental scientific and clinical studies, yet realization lacks effective methods.
Xiaochuan Dai, Wei Zhou, Teng Gao, Jia Liu, Charles M. Lieber   +4 more
semanticscholar   +1 more source

Consequences of converting graded to action potentials upon neural information coding and energy efficiency [PDF]

, 2014
Information is encoded in neural circuits using both graded and action potentials, converting between them within single neurons and successive processing layers. This conversion is accompanied by information loss and a drop in energy efficiency.
A Borst, A Destexhe, A Hasenstaub, A Manwani, A Manwani, A Treves, AA Lazar, AA Lazar, AA Lazar, AL Hodgkin, AS French, B Aguera y Arcas, B Sengupta, B Sengupta, B Sengupta, B Sengupta, B Sengupta, BA Olshausen, BC Carter, Biswa Sengupta, C Koch, C Koch, C Shannon, CC Chow, D Attwell, D Desmaisons, D Lee, DM MacKay, DT Gillespie, E Marder, E Salinas, E Schneidman, E Skaugen, EM Izhikevich, F Theunissen, FA Dodge Jr, G Laurent, G Marsaglia, GG de Polavieja, H Alle, H Alle, J Haag, JA White, JA White, JC Rekling, JC Skou, JD Victor, JD Victor, JE Niven, JE Niven, JE Niven, JE Niven, JE Niven, Jeremy Edward Niven, K Koch, M Juusola, M Matsumoto, M Pinsker, M Stemmler, MB Kennel, ME Larkum, MH Kole, MN Shadlen, MS Grubb, MV Srinivasan, NJ Lenn, O Bernander, Olaf Sporns, PG Lillywhite, PN Steinmetz, R Guttman, R Sarpeshkar, RA DiCaprio, RRdR van Steveninck, S Curti, S Laughlin, SB Laughlin, Simon Barry Laughlin, SP Strong, SR Williams, TJ Gawne, V Prelov, W Singer, Y Shu, ZF Mainen   +84 more
core   +3 more sources

Re-modeling Chara action potential: II. The action potential form under salinity stress

AIMS Biophysics, 2017
In part I we established Thiel-Beilby model of the Chara action potential (AP). In part II the AP is investigated in detail at the time of saline stress.
Mary Jane Beilby, Sabah Al Khazaaly
doaj   +1 more source

Calcineurin Aβ gene knockdown inhibits transient outward potassium current ion channel remodeling in hypertrophic ventricular myocyte

Open Life Sciences, 2021
It has been shown that the activation of calcineurin is involved in regulating ion channel remodeling in hypertrophic cardiomyocytes. But the precise role of calcineurin in the regulation of transient outward potassium current (I to), an ...
Yang Long, Deng Na, He Jionghong, Xia Guiling, Yang Ying, Zhao Yidong, Huo Zhaomei, Guo Chuxian   +7 more
doaj   +1 more source

Ca2+ and Membrane Potential Transitions During Action Potentials Are Self-Similar to Each Other and to Variability of AP Firing Intervals Across the Broad Physiologic Range of AP Intervals During Autonomic Receptor Stimulation

Frontiers in Physiology, 2021
Ca2+ and Vm transitions occurring throughout action potential (AP) cycles in sinoatrial nodal (SAN) cells are cues that (1) not only regulate activation states of molecules operating within criticality (Ca2+ domain) and limit-cycle (Vm domain) mechanisms
Dongmei Yang, Christopher H. Morrell, Christopher H. Morrell, Alexey E. Lyashkov, Syevda Tagirova Sirenko, Ihor Zahanich, Yael Yaniv, Tatiana M. Vinogradova, Bruce D. Ziman, Victor A. Maltsev, Edward G. Lakatta   +10 more
doaj   +1 more source

A model of the electrical behaviour of myelinated sensory nerve fibres based on human data [PDF]

, 1999
Calculation of the response of human myelinated sensory nerve fibres to spinal cord stimulation initiated the development of a fibre model based on electro-physiological and morphometric data for human sensory nerve fibres.
Boom, H.B.K., Holsheimer, J., Wesselink, W.A.   +2 more
core   +2 more sources

Exercise promotes motor functional recovery in rats with corticospinal tract injury: anti-apoptosis mechanism

Neural Regeneration Research, 2015
Studies have shown that exercise interventions can improve functional recovery after spinal cord injury, but the mechanism of action remains unclear. To investigate the mechanism, we established a unilateral corticospinal tract injury model in rats by ...
Ting-ting Hou, Xiao-yu Yang, Peng Xia, Su Pan, Jian Liu, Zhi-ping Qi   +5 more
doaj   +1 more source

Highly Efficient Conversion of Motor Neuron-Like NSC-34 Cells into Functional Motor Neurons by Prostaglandin E₂

Cells, 2020
Motor neuron diseases are a group of progressive neurological disorders that degenerate motor neurons. The neuroblastoma × spinal cord hybrid cell line NSC-34 is widely used as an experimental model in studies of motor neuron diseases.
Hiroshi Nango, Yasuhiro Kosuge, Masaki Sato, Yoshiyuki Shibukawa, Yuri Aono, Tadashi Saigusa, Yoshihisa Ito, Kumiko Ishige   +7 more
doaj   +1 more source

Dynamic Moment Analysis of the Extracellular Electric Field of a Biologically Realistic Spiking Neuron [PDF]

, 2007
Based upon the membrane currents generated by an action potential in a biologically realistic model of a pyramidal, hippocampal cell within rat CA1, we perform a moment expansion of the extracellular field potential.
Koch, Christof, Milstein, J. N.
core   +3 more sources