The eukaryotic initiation factor 2 kinase GCN2 protects against hepatotoxicity during asparaginase treatment [PDF]
, 2013 Asparaginase is an important drug in the treatment regimen for acute lymphoblastic leukemia. Asparaginase depletes circulating asparagine and glutamine, activating an amino acid stress response (AAR) involving phosphorylation of eukaryotic initiation ...
Anthony, Tracy G. +4 more
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Fibroblast growth factor 2 positively regulates expression of activating transcription factor 4 in osteoblasts [PDF]
Biochemical and Biophysical Research Communications, 2010 Our previous studies showed that basic fibroblast growth factor 2 (FGF2) null mice display markedly reduced bone mass and bone formation. However, the mechanism by which FGF2 regulates bone mass or bone formation is not fully defined. Activating transcription factor 4 (ATF4), one member of activating transcription factor/cAMP response element binding ...
Yurong, Fei +2 more
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Effect of leucine on endoplasmic reticulum stress induced by early weaning in the liver of piglets
浙江大学学报. 农业与生命科学版, 2018 To investigate the effects of dietary leucine supplementation on endoplasmic reticulum (ER) stress in the liver of early-weaning piglets, we explored the morphology of liver cells, expression pattern of ER stress-associated proteins, and effects on ER ...
FAN Qiwen +4 more
doaj +1 more source
Activating transcription factor 4 and X box binding protein 1 of Litopenaeus vannamei transcriptional regulated white spot syndrome virus genes Wsv023 and Wsv083. [PDF]
PLoS ONE, 2013 In response to endoplasmic reticulum (ER) stress, the signaling pathway termed unfolded protein response (UPR) is activated. To investigate the role of UPR in Litopenaeus vannamei immunity, the activating transcription factor 4 (designated as LvATF4 ...
Xiao-Yun Li +7 more
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O-GlcNAc regulates the mitochondrial integrated stress response by regulating ATF4
Frontiers in Aging Neuroscience, 2023 BackgroundAccumulation of mitochondrial dysfunctional is a hallmark of age-related neurodegeneration including Alzheimer’s disease (AD). Impairment of mitochondrial quality control mechanisms leading to the accumulation of damaged mitochondria and ...
Ibtihal M. Alghusen +14 more
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Regression/eradication of gliomas in mice by a systemically-deliverable ATF5 dominant-negative peptide. [PDF]
, 2016 Malignant gliomas have poor prognosis and urgently require new therapies. Activating Transcription Factor 5 (ATF5) is highly expressed in gliomas, and interference with its expression/function precipitates targeted glioma cell apoptosis in vitro and in ...
Angelastro, James +11 more
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Inhibition of hepatocyte nuclear factor 4 transcriptional activity by the nuclear factor κB pathway [PDF]
Biochemical Journal, 2006 HNF-4 (hepatocyte nuclear factor 4) is a key regulator of liver-specific gene expression in mammals. We have shown previously that the activity of the human APOC3 (apolipoprotein C-III) promoter is positively regulated by the anti-inflammatory cytokine TGFβ (transforming growth factor β) and its effectors Smad3 (similar to mothers against ...
Varvara, Nikolaidou-Neokosmidou +2 more
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Regulation of Vascular Endothelial Growth Factor A by Activating Transcription Factor 4 [PDF]
Circulation Research, 2008 To the Editor: In a recent article published in Circulation Research , Malabanan et al demonstrated that expression of vascular endothelial growth factor (VEGF)-A in response to fibroblast growth factor-2 is regulated by …
Steven F. Abcouwer, C. Nathaniel Roybal
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The molecular basis of T cell acute lymphoblastic leukemia [PDF]
, 2012 T cell acute lymphoblastic leukemias (T-ALLs) arise from the malignant transformation of hematopoietic progenitors primed toward T cell development, as result of a multistep oncogenic process involving constitutive activation of NOTCH signaling and ...
Adolfo Ferrando +23 more
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ATF4 (activating transcription factor 4 (tax-responsive enhancer element B67)) [PDF]
Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2011 Review on ATF4 (activating transcription factor 4 (tax-responsive enhancer element B67)), with data on DNA, on the protein encoded, and where the gene is implicated.
Ameri, K, Harris, AL
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