Results 21 to 30 of about 4,243,823 (319)

Cryomicroscopy reveals the structural basis for a flexible hinge motion in the immunoglobulin M pentamer

Nature Communications, 2022
Immunoglobulin M (IgM) is the Ig isotype that serves as the first line of host defence during infection. Here, the authors image the full-length IgM pentamer by cryo-EM, revealing the structure and hinge motion of the antigen binding domains.
Qu Chen, Rajesh Menon, Lesley J. Calder, Pavel Tolar, Peter B. Rosenthal   +4 more
doaj   +1 more source

Differential roles for the adapters Gads and LAT in platelet activation by GPVI and CLEC-2 [PDF]

, 2008
Background: The adapter proteins SLP-76 and LAT have been shown to play critical roles in the activation of PLCc2 in platelets downstream of GPVI/FcRc and the C-type lectin receptor CLEC-2.
Pearce, AC, Watson, Steve P, Watson, Steve P., Eble, JA, Pearce, Andrew C., Pearce, A C, Hughes, C E, McGlade, Jane, Eble, Johannes A., Auger, Jocelyn; id_orcid, McGlade, J, Auger, Jocelyn M., Watson, Steve; id_orcid, Eble, J A, Pearce, Andrew C, Auger, J M, Watson, S P, Hughes, Craig, Hughes, C.E, Hughes, Craig E.   +19 more
core   +1 more source

Active voice, active writing [PDF]

Ubiquity, 2020
Each "Communication Corner" essay is self-contained; however, they build on each other. For best results, before reading this essay and doing the exercise, go to the first essay "How an Ugly Duckling Became a Swan," then read each succeeding essay. Knowing when to write in the active or passive voice can fundamentally improve your work, but ...
openaire   +1 more source

Loss of RASGRP1 in humans impairs T‐cell expansion leading to Epstein‐Barr virus susceptibility

EMBO Molecular Medicine, 2018
Inherited CTPS1, CD27, and CD70 deficiencies in humans have revealed key factors of T‐lymphocyte expansion, a critical prerequisite for an efficient immunity to Epstein–Barr virus (EBV) infection.
Sarah Winter, Emmanuel Martin, David Boutboul, Christelle Lenoir, Sabah Boudjemaa, Arnaud Petit, Capucine Picard, Alain Fischer, Guy Leverger, Sylvain Latour   +9 more
doaj   +1 more source

Dinuclear PhosphoiminoBINOL-Pd Container for Malononitrile: Catalytic Asymmetric Double Mannich Reaction for Chiral 1,3-Diamine Synthesis

Scientific Reports, 2018
A phosphoiminoBINOL ligand was designed to form a dinuclear metal complex that could hold a malononitrile molecule. The dinuclear bis(phosphoimino)binaphthoxy-Pd2(OAc)2 complex catalyzed a double Mannich reaction of N-Boc-imines with malononitrile to ...
Takayoshi Arai, Katsuya Sato, Ayu Nakamura, Hiroki Makino, Hyuma Masu   +4 more
doaj   +1 more source

Retrograde and Anterograde Transport of Lat-Vesicles during the Immunological Synapse Formation: Defining the Finely-Tuned Mechanism

Cells, 2021
LAT is an important player of the signaling cascade induced by TCR activation. This adapter molecule is present at the plasma membrane of T lymphocytes and more abundantly in intracellular compartments.
Juan José Saez, Stephanie Dogniaux, Massiullah Shafaq-Zadah, Ludger Johannes, Claire Hivroz, Andrés Ernesto Zucchetti   +5 more
doaj   +1 more source

Interrogating ligand-receptor interactions using highly sensitive cellular biosensors

Nature Communications, 2023
Interactions of membrane-resident proteins are important targets for therapeutic interventions but most methods to study them are either costly, laborious or fail to reflect the physiologic interaction of membrane resident proteins in trans.
Maximilian A. Funk, Judith Leitner, Marlene C. Gerner, Jasmin M. Hammerler, Benjamin Salzer, Manfred Lehner, Claire Battin, Simon Gumpelmair, Karin Stiasny, Katharina Grabmeier-Pfistershammer, Peter Steinberger   +10 more
doaj   +1 more source

Regulation of caspase-3 processing by cIAP2 controls the switch between pro-inflammatory activation and cell death in microglia. [PDF]

, 2014
The activation of microglia, resident immune cells of the central nervous system, and inflammation-mediated neurotoxicity are typical features of neurodegenerative diseases, for example, Alzheimer's and Parkinson's diseases. An unexpected role of caspase-
Rodhe, J, Venero, JL, Rodhe, J,, Rodhe, Johanna, Joseph, B, Burguillos García, Miguel Ángel, Venero Recio, José Luis, Kavanagh, E, Burguillos, MA, Kavanagh, Edel T., Joseph, Bertrand, Joseph, B,   +11 more
core   +1 more source

B cells extract antigens at Arp2/3-generated actin foci interspersed with linear filaments

eLife, 2019
Antibody production depends on B cell internalization and presentation of antigens to helper T cells. To acquire antigens displayed by antigen-presenting cells, B cells form immune synapses and extract antigens by the mechanical activity of the acto ...
Sophie I Roper, Laabiah Wasim, Dessislava Malinova, Michael Way, Susan Cox, Pavel Tolar   +5 more
doaj   +1 more source

Diffusion and activation of phosphorus in germanium

, 2008
International audienceIn this work we investigate the diffusion and the activation behavior of implanted phosphorus in Ge. We used both conventional thermal processing as well as laser annealing by pulsed ns Nd–YAG laser.
Claverie, Alain, Tsouroutas, P, Tsoukalas, D., Zergioti, I, Claverie, A, Cherkashin, Nikolay, Cherkashin, N, Tsoukalas, D, Zergioti, I., Tsouroutas, P.   +9 more
core   +1 more source