Results 21 to 30 of about 6,391,825 (297)

Not All Immune Checkpoints Are Created Equal

Frontiers in Immunology, 2018
Antibodies that block T cell inhibition via the immune checkpoints CTLA-4 and PD-1 have revolutionized cancer therapy during the last 15 years. T cells express additional inhibitory surface receptors that are considered to have potential as targets in ...
Annika De Sousa Linhares, Judith Leitner, Katharina Grabmeier-Pfistershammer, Peter Steinberger   +3 more
doaj   +1 more source

FcγR requirements and costimulatory capacity of Urelumab, Utomilumab, and Varlilumab

Frontiers in Immunology, 2023
IntroductionTargeting costimulatory receptors of the tumor necrosis factor receptor (TNFR) superfamily with agonistic antibodies is a promising approach in cancer immuno therapy.
Judith Leitner, Ricarda Egerer, Petra Waidhofer-Söllner, Katharina Grabmeier-Pfistershammer, Peter Steinberger   +4 more
doaj   +1 more source

Loss of RASGRP1 in humans impairs T‐cell expansion leading to Epstein‐Barr virus susceptibility

EMBO Molecular Medicine, 2018
Inherited CTPS1, CD27, and CD70 deficiencies in humans have revealed key factors of T‐lymphocyte expansion, a critical prerequisite for an efficient immunity to Epstein–Barr virus (EBV) infection.
Sarah Winter, Emmanuel Martin, David Boutboul, Christelle Lenoir, Sabah Boudjemaa, Arnaud Petit, Capucine Picard, Alain Fischer, Guy Leverger, Sylvain Latour   +9 more
doaj   +1 more source

Cryomicroscopy reveals the structural basis for a flexible hinge motion in the immunoglobulin M pentamer

Nature Communications, 2022
Immunoglobulin M (IgM) is the Ig isotype that serves as the first line of host defence during infection. Here, the authors image the full-length IgM pentamer by cryo-EM, revealing the structure and hinge motion of the antigen binding domains.
Qu Chen, Rajesh Menon, Lesley J. Calder, Pavel Tolar, Peter B. Rosenthal   +4 more
doaj   +1 more source

Silodosin inhibits noradrenaline-activated transcription factors Elk1 and SRF in human prostate smooth muscle. [PDF]

, 2012
The transcription factors Elk1 and serum response factor (SRF) are central regulators of cell cycle and phenotype in various cell types. Elk1 is activated by phosphorylation (serine-383), while activation of SRF requires its co-factor, myocardin ...
Andersson, Karl-Erik, Beckmann, Christer, Füllhase, Claudius, Gratzke, Christian, Hedlund, Petter, Hennenberg, Martin, Montorsi, Francesco, Rutz, Beata, Stief, Christian Georg, Strittmatter, Frank, Waidelich, Raphaela   +10 more
core   +6 more sources

Voluntary activation of human knee extensors measured using transcranial magnetic stimulation [PDF]

, 2009
The aim of this study was to determine the applicability and reliability of a transcranial magnetic stimulation twitch interpolation technique for measuring voluntary activation of a lower limb muscle group.
Goodall, Stuart, Romer, Lee, Ross, Emma
core   +1 more source

Dinuclear PhosphoiminoBINOL-Pd Container for Malononitrile: Catalytic Asymmetric Double Mannich Reaction for Chiral 1,3-Diamine Synthesis

Scientific Reports, 2018
A phosphoiminoBINOL ligand was designed to form a dinuclear metal complex that could hold a malononitrile molecule. The dinuclear bis(phosphoimino)binaphthoxy-Pd2(OAc)2 complex catalyzed a double Mannich reaction of N-Boc-imines with malononitrile to ...
Takayoshi Arai, Katsuya Sato, Ayu Nakamura, Hiroki Makino, Hyuma Masu   +4 more
doaj   +1 more source

Retrograde and Anterograde Transport of Lat-Vesicles during the Immunological Synapse Formation: Defining the Finely-Tuned Mechanism

Cells, 2021
LAT is an important player of the signaling cascade induced by TCR activation. This adapter molecule is present at the plasma membrane of T lymphocytes and more abundantly in intracellular compartments.
Juan José Saez, Stephanie Dogniaux, Massiullah Shafaq-Zadah, Ludger Johannes, Claire Hivroz, Andrés Ernesto Zucchetti   +5 more
doaj   +1 more source

Interrogating ligand-receptor interactions using highly sensitive cellular biosensors

Nature Communications, 2023
Interactions of membrane-resident proteins are important targets for therapeutic interventions but most methods to study them are either costly, laborious or fail to reflect the physiologic interaction of membrane resident proteins in trans.
Maximilian A. Funk, Judith Leitner, Marlene C. Gerner, Jasmin M. Hammerler, Benjamin Salzer, Manfred Lehner, Claire Battin, Simon Gumpelmair, Karin Stiasny, Katharina Grabmeier-Pfistershammer, Peter Steinberger   +10 more
doaj   +1 more source

Rap1 binding and a lipid-dependent helix in talin F1 domain promote integrin activation in tandem. [PDF]

, 2019
Rap1 GTPases bind effectors, such as RIAM, to enable talin1 to induce integrin activation. In addition, Rap1 binds directly to the talin1 F0 domain (F0); however, this interaction makes a limited contribution to integrin activation in CHO cells or ...
Alexandre R. Gingras, Andrew J. Valadez, Anthis, Bromberger, Calderwood, Camp, Critchley, Frederic Lagarrigue, Frojmovic, Gingras, Goult, Haling, Han, Hynes, Klapproth, Klaus Ley, Lagarrigue, Lagarrigue, Lee, Marcus Zorovich, Mark H. Ginsberg, Miguel Alejandro Lopez-Ramirez, Monica N. Cuevas, Nicolas Seban, Nieswandt, O’Toole, Petrich, Petrich, Plak, Shattil, Shattil, Simonson, Song, Stefanini, Stritt, Su, Sun, Tadokoro, Vranken, Wegener, William B. Kiosses, Wilma McLaughlin, Ye, Zeiler, Zhu   +44 more
core   +2 more sources