Results 111 to 120 of about 341,650 (296)

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Daytime plasma cortisol and cortisol response to dexamethasone suppression are associated with a prothrombotic state in hypertension

Frontiers in Endocrinology
Background and aimsA prothrombotic state was demonstrated in patients with Cushing’s syndrome and is involved in the development and progression of cardiovascular and renal damage in hypertensive patients.
Gabriele Brosolo, Andrea Da Porto, Luca Bulfone, Antonio Vacca, Nicole Bertin, Cinzia Vivarelli, Cristiana Catena, Leonardo A. Sechi, Leonardo A. Sechi, Leonardo A. Sechi   +9 more
doaj   +1 more source

Circadian Rhythms in the CNS and Peripheral Clock Disorders: Role of the Biological Clock in Cardiovascular Diseases

Journal of Pharmacological Sciences, 2007
The cardiovascular diseases are closely related to circadian rhythm, which is under the control of the biological clock. Clock genes show circadian oscillation not only in the suprachiasmatic nucleus but also in peripheral tissues, suggesting the ...
Koji Maemura, Norihiko Takeda, Ryozo Nagai   +2 more
doaj   +1 more source

Reduced Order Optimal Control of the Convective FitzHugh-Nagumo Equation

, 2019
In this paper, we compare three model order reduction methods: the proper orthogonal decomposition (POD), discrete empirical interpolation method (DEIM) and dynamic mode decomposition (DMD) for the optimal control of the convective FitzHugh-Nagumo (FHN ...
Karasözen, Bülent, Küçükseyhan, Tuğba, Uzunca, Murat   +2 more
core   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Modern ideas of the role of the immune process and hemostasis in the pathogenesis of sepsis

Acta Biomedica Scientifica
The pathogenesis of sepsis as a pathological process, which is based on the body’s reaction in the form of generalized (systemic) inflammation to an infection of various nature, leading to acute multi-organ dysfunction, includes changes in the immune ...
M. V. Osikov, L. F. Telesheva, A. G. Konashov, A. V. Gusev, V. A. Konashov   +4 more
doaj   +1 more source

A cross-sectional study on the expression of fibrinolytic system components and metalloproteinase-9 in women with early-stage and metastases breast cancer in Tucumán, Argentina [PDF]

Einstein (São Paulo)
Objective: The hemostatic and matrix metalloproteinase (MMP) systems are known to be altered in patients with breast cancer. This cross-sectional study aimed to explore the fibrinolysis components values and MMP-9 levels in a specific population of ...
Mariano Nicolás Áleman, María Constanza Luciardi, Rosa Silvina Guber, Analía Graciela Soria   +3 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Analyzing the dynamic behavior of the Gierer–Meinhardt model using finite difference method

AIP Advances
In this paper, a numerical computation method for the Gierer–Meinhardt model in two-dimensional space diffusion with homogeneous Neumann boundary conditions, considering the interaction between activator and inhibitor substances, is proposed.
Jianping Lv, Hefang Jing
doaj   +1 more source