Results 101 to 110 of about 234,823 (303)

Unravelling the impact of SARS-CoV-2 on hemostatic and complement systems: a systems immunology perspective

Frontiers in Immunology
The hemostatic system prevents and stops bleeding, maintaining circulatory integrity after injury. It directly interacts with the complement system, which is key to innate immunity.
Didar Murad, Rehan Zafar Paracha, Maryum Nisar   +2 more
doaj   +1 more source

Host Plasminogen Activator Inhibitor-1 Promotes Human Skin Carcinoma Progression in a Stage-Dependent Manner

Neoplasia: An International Journal for Oncology Research, 2005
Angiogenesis and tumor expansion are associated with extracellular matrix remodeling and involve various proteases such as the plasminogen (Pig)/plasminogen activator (PA) system.
Catherine Maillard, Maud Jost, Maria Unni Rømer, Nils Brunner, Xavier Houard, Annabelle Lejeune, Carine Munaut, Khalid Bajou, Laurence Melen, Keld Dano, Peter Carmeliet, Norbert E. Fusenig, Jean Michel Foidart, Agnès Noel   +13 more
doaj   +1 more source

Annihilation of turbulence in excitable systems using pulses that inhibit activator growth

, 2002
We consider turbulence consisting of erratically moving wave pieces in excitable systems. We investigate three such systems: numerical solutions of the Bär-Eiswirth model, a quasi-two- dimensional experimental setup for the Belousov-Zhabotinsky (BZ ...
Mario Markus, Woltering, M., Markus, M., Matthias Woltering, Markus, Mario, Woltering, Matthias   +5 more
core   +1 more source

Flow-distributed spikes for Schnakenberg kinetics [PDF]

, 2011
This is the post-print version of the final published paper. The final publication is available at link.springer.com by following the link below. Copyright @ 2011 Springer-Verlag.We study a system of reaction–diffusion–convection equations which combine ...
Winter, M, Juncheng Wei, Matthias Winter, Wei, J   +3 more
core   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Dilution and titration of cell-cycle regulators may control cell size in budding yeast.

PLoS Computational Biology, 2018
The size of a cell sets the scale for all biochemical processes within it, thereby affecting cellular fitness and survival. Hence, cell size needs to be kept within certain limits and relatively constant over multiple generations.
Frank S Heldt, Reece Lunstone, John J Tyson, Béla Novák   +3 more
doaj   +1 more source

Genetic Architecture of Tissue-Type Plasminogen Activator and Plasminogen Activator Inhibitor-1

, 2008
Important biochemical constituents of the fibrinolytic system include tissue-type plasminogen activator (t-PA) and plasminogen activator inhibitor-1 (PAI-1). In the current review, we aim to describe the genetic architecture of t-PA and PAI-1.
van Gilst, Wiek H., Moore, Jason H., Snieder, Harold; id_orcid, Pattin, Kristine, Hillege, Hans L., Snieder, Harold, Asselbergs, Folkert W.   +6 more
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Circadian Rhythms in the CNS and Peripheral Clock Disorders: Role of the Biological Clock in Cardiovascular Diseases

Journal of Pharmacological Sciences, 2007
The cardiovascular diseases are closely related to circadian rhythm, which is under the control of the biological clock. Clock genes show circadian oscillation not only in the suprachiasmatic nucleus but also in peripheral tissues, suggesting the ...
Koji Maemura, Norihiko Takeda, Ryozo Nagai   +2 more
doaj   +1 more source

An instability criterion for activator–inhibitor systems in a two-dimensional ball

Journal of Differential Equations, 2006
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
openaire   +2 more sources