Results 101 to 110 of about 341,650 (296)
PLoS ONE, 2014 In recent years members of the tripartite motif-containing (TRIM) family of E3 ubiquitin ligases have been shown to both positively and negatively regulate viral defence and as such are emerging as compelling targets for modulating the anti-viral immune ...
Claire Wynne +10 more
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Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Frontiers in ImmunologyThe hemostatic system prevents and stops bleeding, maintaining circulatory integrity after injury. It directly interacts with the complement system, which is key to innate immunity.
Didar Murad +2 more
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Neoplasia: An International Journal for Oncology Research, 2005 Angiogenesis and tumor expansion are associated with extracellular matrix remodeling and involve various proteases such as the plasminogen (Pig)/plasminogen activator (PA) system.
Catherine Maillard +13 more
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Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Dilution and titration of cell-cycle regulators may control cell size in budding yeast.
PLoS Computational Biology, 2018 The size of a cell sets the scale for all biochemical processes within it, thereby affecting cellular fitness and survival. Hence, cell size needs to be kept within certain limits and relatively constant over multiple generations.
Frank S Heldt +3 more
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Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Control of transversal instabilities in reaction-diffusion systems
New Journal of Physics, 2018 In two-dimensional reaction-diffusion systems, local curvature perturbations on traveling waves are typically damped out and vanish. However, if the inhibitor diffuses much faster than the activator, transversal instabilities can arise, leading from flat
Sonja Totz +3 more
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The effect of light quality on the expression of stomatal development genes of maize
Photosynthetica, 2019 Light-induced stomatal development is mediated through a crosstalk between cryptochrome (CRY), phytochrome (phy), and constitutive photomorphogenic 1 (COP1)-signaling systems.
T.D. LIU, X.W. ZHANG, Y. XU
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Global existence of solutions of an activator-inhibitor system
Discrete & Continuous Dynamical Systems - A, 2006 We consider the generalized Gierer-Meinhardt system $\frac{\partial u_{j}}{\partial t}=d_{j}$Δ $u_{j}- a_{j}u_{j} +g_{j}(x,u) \ \ \text{in}\ \ \Omega\times[0,T) $ , $\frac{\partial u_{j}}{\partial\nu}=0\ \ \text{on}\ \ \partial\Omega\times[ 0,T) $, $u_{j}(x,0) =\varphi_{j}(x)\ \ \text{in}\ \ \Omega$ where $\Omega$ is a smooth ...
openaire +1 more source