Results 81 to 90 of about 234,823 (303)

Effect of valsartan on angiotensin II-induced plasminogen activator inhibitor-1 biosynthesis in arterial smooth muscle cells [PDF]

, 2001
Previous studies have shown that angiotensin II stimulates the synthesis of plasminogen activator inhibitor-1 in cultured vascular cells, which suggests that activation of the renin-angiotensin system may impair fibrinolysis.
L. Sironi, L. Arnaboldi, L. Mussoni, A. Corsini, E. Tremoli, M. de Gasparo, CALVIO, ANNA MARIA, A. Parolari   +7 more
core  

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Prediction of life quality based on Behavioral Activator-Inhibitor Systems and adulthood hyperactivity in male drug abusers

فصلنامه روان‌شناسی کاربردی, 2019
Aim: The aim of this research was to predict life quality based on behavioral activator and inhibitor systems and adulthood hyperactivity in male drug abusers. Method: A correlational method was employed. The statistical population consisted of 1637 drug
معصومه شاه محمدی, صادق تقی لو   +1 more
doaj  

2-Aminoethoxydiphenyl borate activates the human mechano-gated KCNK channels KCNK 2 (TREK-1), KCNK 4 (TRAAK) and KCNK 10 (TREK-2).

Frontiers in Pharmacology, 2013
: Two-pore domain K+ (KCNK, K2P) channels underlie the leak (background) potassium conductance in many types of excitable cells. They oppose membrane depolarization and cell excitability.
Leopoldo Raul Beltran, Madeline eBeltran, Ainhara eAguado, Guenter eGisselmann, Hanns eHatt   +4 more
doaj   +1 more source

NAMPT Inhibitor and P73 Activator Represses P53 R175H Mutated HNSCC Cell Proliferation in a Synergistic Manner

, 2022
The p53 family has the following three members: p53, p63 and p73. p53 is a tumor suppressor gene that frequently exhibits mutation in head and neck cancer.
Ching-Feng Lien, Yi-Chiang Hsu, Ming-Han Wu, Bi-He Cai, Zhi-Yu Bai, Wei-Chen Wu, Si-Jie Yu, Rui-Yu Lu, Chia-Chi Chen   +8 more
core   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

A multiple scale pattern formation cascade in reaction-diffusion systems of activator-inhibitor type

, 2018
A family of singular limits of reaction-diffusion systems of activator-inhibitor type in which stable stationary sharp-interface patterns may form is investigated.
Muratov, Cyrill B., Muratov, CB, Henry, Marie, Hilhorst, Danielle, Henry, M, Hilhorst, D   +5 more
core   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Physical interactions enable energy-efficient Turing patterns

Physical Review Research
Patterns are ubiquitous in nature, but how they form is often unclear. Turing developed a seminal theory to explain patterns based on reactions that counteract the equalizing tendency of diffusion.
Cathelijne ter Burg, David Zwicker
doaj   +1 more source

SARS-COV-2 causes significant abnormalities in the fibrinolysis system of patients: correlation between viral mutations, variants and thrombosis

Frontiers in Cellular and Infection Microbiology
BackgroundCoronavirus disease (COVID-19) is reported as a complex disorder affecting multiple systems and coagulopathy that can cause mortality. In this study, we investigated the correlation of SARS-CoV-2 mutations found in blood samples with various ...
Esra’a Abudouleh, Tarek Owaidah, Tarek Owaidah, Fatimah Alhamlan, Fatimah Alhamlan, Arwa A. Al-Qahtani, Reem M. Aljowaie, Fatimah Al-Ghnnam, Marie Fe Bohol, Ahmed A. Al-Qahtani, Ahmed A. Al-Qahtani   +10 more
doaj   +1 more source