Results 81 to 90 of about 341,650 (296)

Activator-inhibitor system with delay and pattern formation

open access: yesMathematical and Computer Modelling, 2005
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
openaire   +2 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Synchronization in heterogeneous FitzHugh-Nagumo networks with hierarchical architecture

open access: yes, 2016
We study synchronization in heterogeneous FitzHugh-Nagumo networks. It is well known that heterogeneities in the nodes hinder synchronization when becoming too large. Here, we develop a controller to counteract the impact of these heterogeneities.
Fradkov, A. L.   +3 more
core   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

open access: yesFEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel   +13 more
wiley   +1 more source

2-Aminoethoxydiphenyl borate activates the human mechano-gated KCNK channels KCNK 2 (TREK-1), KCNK 4 (TRAAK) and KCNK 10 (TREK-2).

open access: yesFrontiers in Pharmacology, 2013
: Two-pore domain K+ (KCNK, K2P) channels underlie the leak (background) potassium conductance in many types of excitable cells. They oppose membrane depolarization and cell excitability.
Leopoldo Raul Beltran   +4 more
doaj   +1 more source

Synthetic in vitro transcriptional oscillators [PDF]

open access: yes, 2011
The construction of synthetic biochemical circuits from simple components illuminates how complex behaviors can arise in chemistry and builds a foundation for future biological technologies.
Kim, Jongmin, Winfree, Erik
core   +1 more source

Diversity and complexity in neural organoids

open access: yesFEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Prediction of life quality based on Behavioral Activator-Inhibitor Systems and adulthood hyperactivity in male drug abusers

open access: yesفصلنامه روان‌شناسی کاربردی, 2019
Aim: The aim of this research was to predict life quality based on behavioral activator and inhibitor systems and adulthood hyperactivity in male drug abusers. Method: A correlational method was employed. The statistical population consisted of 1637 drug
معصومه شاه محمدی   +1 more
doaj  

Analyzing critical propagation in a reaction-diffusion-advection model using unstable slow waves

open access: yes, 2014
The effect of advection on the critical minimal speed of traveling waves is studied. Previous theoretical studies estimated the effect on the velocity of stable fast waves and predicted the existence of a critical advection strength below which ...
Dahlem, Markus A.   +2 more
core   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

open access: yesFEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz   +11 more
wiley   +1 more source

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