Results 61 to 70 of about 234,823 (303)

Acute exercise-induced changes in hemostatic and fibrinolytic properties: analogies, similarities, and differences between normotensive subjects and patients with essential hypertension

Platelets, 2019
Following acute exercise, normotensive and hypertensive subjects both undergo changes in hemostatic and fibrinolytic properties, but the hypertensive patient’s response to exercise is exaggerated and prolonged, exposing them to increased cardiovascular ...
Annabella Braschi
doaj   +1 more source

Amplitude equations for activator-inhibitor system with superdiffusion [PDF]

Mathematical Modeling and Computing, 2016
The generalized activator-inhibitor model with cubic nonlinearity, in which the classical Laplacian is replaced by fractional operator has been studied. The fractional operator reflects the nonlocal behavior of superdiffusion. A spatially homogeneous, time independent solution has been found and its linear stability was studied.
openaire   +2 more sources

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Dysregulation of autophagy in chronic lymphocytic leukemia with the small-molecule Sirtuin inhibitor Tenovin-6

, 2013
The authors acknowledge TENOVUS Tayside for funding the studyTenovin-6 (Tnv-6) is a bioactive small molecule with anti-neoplastic activity. Inhibition of the Sirtuin class of protein deacetylases with activation of p53 function is associated with the pro-
Coates, Philip J., Groves, M.J., Prescott, A.R., Nicolaou, A., Murray, Karen, Ganley, Ian G.; id_orcid, Lain, S., Tauro, S., Haydock, S., Appleyard, V., Ganley, I.G., James, John, Nicolaou, Anna; id_orcid, Cunningham, Joan, Cunningham, J., Tauro, Sudhir, Murray, K., Prescott, Alan R., Drbal, Abed Alnaser A.A., Coates, P.J., James, J., MacCallum, S., Lain, Sonia, Drbal, A.A., MacCallum, Stephanie F., Drbal, Abed A., Haydock, Sally, Westwood, N.J., Prescott, Alan R.; id_orcid, Ganley, Ian G., Groves, Michael J., Nicolaou, Anna, Westwood, Nicholas J., Appleyard, Virginia   +33 more
core   +1 more source

Assessment of the stability of TGFβ3 bioactivity for potential bioreactor applications [PDF]

, 2008
In order to develop suitable bioreactor systems and processes for automated and standardized cell cultures involving the use of bioactive factors, we determined the stability of transforming growth factor beta 3 (TGF beta 3) over storage time and under ...
Vonwil, D., Stroebel, S., Wallny, H. J., Martin, I., Gygax, D., Heberer, M., Wendt, D.   +6 more
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Pathogenesis of respiratory failure in COVID-19 due to coagulopathy and endothelial dysfunction

Acta Biomedica Scientifica
Respiratory failure is known to be the main clinical manifestation of COVID-19. However, the mechanism of its development has not been sufficiently studied.
T. O. Burdienko
doaj   +1 more source

Turing Patterning Using Gene Circuits with Gas-Induced Degradation of Quorum Sensing Molecules. [PDF]

PLoS ONE, 2016
The Turing instability was proposed more than six decades ago as a mechanism leading to spatial patterning, but it has yet to be exploited in a synthetic biology setting.
Bartłomiej Borek, Jeff Hasty, Lev Tsimring   +2 more
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source