Results 41 to 50 of about 234,823 (303)

Vliyanie metformina na provospalitel'nyei prokoagulyantnye narusheniya u patsientokv postmenopauze s metabolicheskim sindromom

Ожирение и метаболизм, 2011
The aim of the study was to assess the effect of metformin plus lifestyle modification on procoagulant and proinflammatory state associated with metabolic syndrome in postmenopausal women. Materials and methods: The 12-month prospective, open, randomized

doaj   +1 more source

MASP-1 of the complement system enhances clot formation in a microvascular whole blood flow model. [PDF]

PLoS ONE, 2018
The complement and coagulation systems closely interact with each other. These interactions are believed to contribute to the proinflammatory and prothrombotic environment involved in the development of thrombotic complications in many diseases ...
Lorenz Jenny, József Dobó, Péter Gál, Gábor Pál, Wilbur A Lam, Verena Schroeder   +5 more
doaj   +1 more source

Immunologically modified enzyme-responsive micelles regulate the tumor microenvironment for cancer immunotherapy

Materials Today Bio, 2022
Immune checkpoint blockade has been proven to have great therapeutic potential and has revolutionized the treatment of tumors. However, various limitations remain, including the low response rate of exhausted T cells and mutual regulation of multiple ...
Zhimin Han, Chunai Gong, Juanjuan Li, Huanhuan Guo, Xinlu Chen, Yangli Jin, Shen Gao, Zongguang Tai   +7 more
doaj   +1 more source

Rapid generation of endogenously driven transcriptional reporters in cells through CRISPR/Cas9 [PDF]

, 2015
CRISPR/Cas9 technologies have been employed for genome editing to achieve gene knockouts and knock-ins in somatic cells. Similarly, certain endogenous genes have been tagged with fluorescent proteins. Often, the detection of tagged proteins requires high
Rojas-Fernandez, Alejandro, Hay, Ronald T., Macartney, Thomas, Herhaus, Lina, Sapkota, Gopal P., Lachaud, Christophe   +5 more
core   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Benzoxazolone Carboxamides: Potent and Systemically Active Inhibitors of Intracellular Acid Ceramidase [PDF]

Angewandte Chemie International Edition, 2014
AbstractThe ceramides are a family of bioactive lipid‐derived messengers involved in the control of cellular senescence, inflammation, and apoptosis. Ceramide hydrolysis by acid ceramidase (AC) stops the biological activity of these substances and influences survival and function of normal and neoplastic cells.
Pizzirani, Daniela*, Bach, Anders*, Realini, Natalia, Armirotti, Andrea, Mengatto, Luisa, Bauer, Inga, Girotto, Stefania, Pagliuca, Chiara, De Vivo, Marco, Summa, Maria, Ribeiro, Alison, Piomelli, Daniele (*Shared 1st authors) (Inside front cover)   +11 more
openaire   +5 more sources

Segregation and pursuit waves in activator-inhibitor systems

, 2021
We investigate the effects of cross-diffusion on propagating waves in an activator-inhibitor system. The model consists of a piecewise linear approximation of FitzHugh-Nagumo kinetics and a cross-diffusion term for either the activator or the inhibitor ...
Horsthemke, Werner, Casas Vázquez, José, Zemskov, Evgeny P., Méndez López, Vicenç   +3 more
core  

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Activator of KAT3 histone acetyltransferase family ameliorates a neurodevelopmental disorder phenotype in the syntaxin 1A ablated mouse model

Cell Reports
Summary: Syntaxin-1A (stx1a) repression causes a neurodevelopmental disorder phenotype, low latent inhibition (LI) behavior, by disrupting 5-hydroxytryptaminergic (5-HTergic) systems. Herein, we discovered that lysine acetyltransferase (KAT) 3B increases
Takahiro Nakayama, Akash K. Singh, Toshiyuki Fukutomi, Noriyuki Uchida, Yasuo Terao, Hiroki Hamada, Takahiro Muraoka, Eswaramoorthy Muthusamy, Tapas K. Kundu, Kimio Akagawa   +9 more
doaj   +1 more source

Spherically symmetric internal layers for activator–inhibitor systems—I. Existence by a Lyapunov–Schmidt reduction

, 2004
Reaction–diffusion systems of activator–inhibitor type are studied on an N-dimensional ball with the homogeneous Neumann boundary conditions. Under the condition that the activator diffuses slowly, reacts rapidly and the inhibitor diffuses rapidly ...
Suzuki, Hiromasa, Kunimochi Sakamoto, Sakamoto, Kunimochi, Hiromasa Suzuki   +3 more
core   +1 more source