Results 41 to 50 of about 341,650 (296)
Boolean versus continuous dynamics on simple two-gene modules
, 2010 We investigate the dynamical behavior of simple modules composed of two genes with two or three regulating connections. Continuous dynamics for mRNA and protein concentrations is compared to a Boolean model for gene activity.
A. V. Hill +6 more
core +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Objective To evaluate selumetinib exposure using therapeutic drug monitoring (TDM) in pediatric patients with neurofibromatosis type 1 (NF1) and plexiform neurofibromas (PN), assess interpatient pharmacokinetic variability, and explore the relationship between drug exposure, clinical response, and adverse effects.
Janka Kovács +8 more
wiley +1 more source
Amplification without instability: applying fluid dynamical insights in chemistry and biology
New Journal of Physics, 2013 While amplification of small perturbations often arises from instability, transient amplification is possible locally even in asymptotically stable systems.
Jonathan H McCoy
doaj +1 more source
Materials Today Bio, 2022 Immune checkpoint blockade has been proven to have great therapeutic potential and has revolutionized the treatment of tumors. However, various limitations remain, including the low response rate of exhausted T cells and mutual regulation of multiple ...
Zhimin Han +7 more
doaj +1 more source
Instability mechanisms of repelling peak solutions in a multi-variable activator–inhibitor system
Chaos: An Interdisciplinary Journal of Nonlinear Science, 2022 We study the linear stability properties of spatially localized single- and multi-peak states generated in a subcritical Turing bifurcation in the Meinhardt model of branching. In one spatial dimension, these states are organized in a foliated snaking structure owing to peak–peak repulsion but are shown to be all linearly unstable, with the number of ...
Edgar Knobloch, Arik Yochelis
openaire +3 more sources
Perspective: network-guided pattern formation of neural dynamics [PDF]
, 2014 The understanding of neural activity patterns is fundamentally linked to an understanding of how the brain's network architecture shapes dynamical processes.
Hilgetag, Claus C. +2 more
core +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Arteriovenous malformations (AVMs) are rare, high‐flow, vascular anomalies that can occur either sporadically or as part of a genetic syndrome. AVMs can progress with serious morbidity and even mortality if left unchecked. Sirolimus is an mTOR inhibitor that is effective in low‐flow vascular malformations; however, its role in AVMs is unclear.
Will Swansson +3 more
wiley +1 more source
Ожирение и метаболизм, 2011 The aim of the study was to assess the effect of metformin plus lifestyle modification on procoagulant and proinflammatory state associated with metabolic syndrome in postmenopausal women. Materials and methods: The 12-month prospective, open, randomized
doaj +1 more source
A stability index for travelling waves in activator-inhibitor systems
Proceedings of the Royal Society of Edinburgh: Section A Mathematics, 2019 AbstractWe consider the stability of nonlinear travelling waves in a class of activator-inhibitor systems. The eigenvalue equation arising from linearizing about the wave is seen to preserve the manifold of Lagrangian planes for a nonstandard symplectic form. This allows us to define a Maslov index for the wave corresponding to the spatial evolution of
Cornwell, Paul +1 more
openaire +3 more sources
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Kaposiform lymphangiomatosis (KLA) is an aggressive complex lymphatic anomaly. Patients exhibit malformed lymphatic vessels and often develop hemorrhagic effusions and elevated angiopoietin‐2 (Ang‐2) levels. A somatic NRAS p.Q61R (NRASQ61R) mutation has been associated with KLA.
C. Griffin McDaniel +3 more
wiley +1 more source