Dissecting the dynamics of signaling events in the BMP, WNT, and NODAL cascade during self-organized fate patterning in human gastruloids. [PDF]
, 2019 During gastrulation, the pluripotent epiblast self-organizes into the 3 germ layers-endoderm, mesoderm and ectoderm, which eventually form the entire embryo.
Chhabra, Sapna +4 more
core +1 more source
Proportion Regulation in Globally Coupled Nonlinear Systems
, 1995 As a model of proportion regulation in differentiation process of biological system, globally coupled activator-inhibitor systems are studied. Formation and destabilization of one and two cluster state are predicted analytically.
A. M. Turing +17 more
core +2 more sources
Roles of calcium/calmodulin-dependent kinase II in long-term memory formation in crickets. [PDF]
PLoS ONE, 2014 Ca(2+)/calmodulin (CaM)-dependent protein kinase II (CaMKII) is a key molecule in many systems of learning and memory in vertebrates, but roles of CaMKII in invertebrates have not been characterized in detail.
Makoto Mizunami +4 more
doaj +1 more source
Frontiers in Neurology, 2023 ObjectiveThis study investigated the diagnostic performance of thrombin–antithrombin complex (TAT), plasmin–α2 plasmin inhibitor complex (PIC), tissue plasminogen activator–plasminogen activator inhibitor complex (t-PAIC), and thrombomodulin (TM) in ...
Xiaoxia Zhao +6 more
doaj +1 more source
Clinical study on the feasibility of new thrombus markers in predicting massive cerebral infarction
Frontiers in Neurology, 2023 ObjectiveThis study investigated the diagnostic performance of the thrombin-antithrombin complex (TAT), plasmin-α2 plasmin inhibitor complex (PIC), tissue plasminogen activator-plasminogen activator inhibitor complex (t-PAIC), and thrombomodulin (TM) in ...
Xiaoxia Zhao +6 more
doaj +1 more source
PAI1 blocks NMDA receptor-mediated effects of tissue-type plasminogen activator on cell signaling and physiology [PDF]
, 2018 The fibrinolysis proteinase tissue-type plasminogen activator (tPA, also known as PLAT) triggers cell signaling and regulates cell physiology. In PC12 cells, Schwann cells and macrophages, the N-methyl-D-aspartate receptor (NMDA-R) mediates tPA signaling.
Azmoon, Pardis +5 more
core +2 more sources
When cytokinin, a plant hormone, meets the adenosine A2A receptor: a novel neuroprotectant and lead for treating neurodegenerative disorders? [PDF]
PLoS ONE, 2012 It is well known that cytokinins are a class of phytohormones that promote cell division in plant roots and shoots. However, their targets, biological functions, and implications in mammalian systems have rarely been examined. In this study, we show that
Yi-Chao Lee +6 more
doaj +1 more source
The filamentation of the laser beam as a labyrinth instability
, 2015 At incident powers much higher than the threshold for filamentation a pulse from a high-power laser generates in the transversal plane a complex structure. It consists of randomly meandering stripes defining connected regions where the field intensity is
Spineanu, Florin, Vlad, Madalina
core +1 more source
Robust network topologies for generating oscillations with temperature-independent periods.
PLoS ONE, 2017 Nearly all living systems feature a temperature-independent oscillation period in circadian clocks. This ubiquitous property occurs at the system level and is rooted in the network architecture of the clock machinery. To investigate the mechanism of this
Lili Wu, Qi Ouyang, Hongli Wang
doaj +1 more source
MASP-1 of the complement system enhances clot formation in a microvascular whole blood flow model. [PDF]
PLoS ONE, 2018 The complement and coagulation systems closely interact with each other. These interactions are believed to contribute to the proinflammatory and prothrombotic environment involved in the development of thrombotic complications in many diseases ...
Lorenz Jenny +5 more
doaj +1 more source