Results 51 to 60 of about 10,333,992 (256)
Segregation and pursuit waves in activator-inhibitor systems
, 2021 We investigate the effects of cross-diffusion on propagating waves in an activator-inhibitor system. The model consists of a piecewise linear approximation of FitzHugh-Nagumo kinetics and a cross-diffusion term for either the activator or the inhibitor ...
Horsthemke, Werner +3 more
core
FEBS Letters, EarlyView.Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi +5 more
wiley +1 more source
Spikes for the Gierer-Meinhardt system in two dimensions: The strong coupling case [PDF]
, 2002 Numerical computations often show that the Gierer-Meinhardt system has stable solutions which display patterns of multiple interior peaks (often also called spots). These patterns are also frequently observed in natural biological systems.
Winter, M, Wei, J
core +1 more source
A chemoenzymatic reaction-diffusion system with local inhibition and distal activation
Nature CommunicationsSpatiotemporal gating in signal transduction and corresponding activation or inhibition of a biochemical pathway is the hallmark of biological functionality.
Rishi Ram Mahato +3 more
doaj +1 more source
Platelets, 2019 Following acute exercise, normotensive and hypertensive subjects both undergo changes in hemostatic and fibrinolytic properties, but the hypertensive patient’s response to exercise is exaggerated and prolonged, exposing them to increased cardiovascular ...
Annabella Braschi
doaj +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
FEBS Letters, EarlyView.Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source
Pathogenesis of respiratory failure in COVID-19 due to coagulopathy and endothelial dysfunction
Acta Biomedica ScientificaRespiratory failure is known to be the main clinical manifestation of COVID-19. However, the mechanism of its development has not been sufficiently studied.
T. O. Burdienko
doaj +1 more source
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source