Results 51 to 60 of about 341,650 (296)

Activator of KAT3 histone acetyltransferase family ameliorates a neurodevelopmental disorder phenotype in the syntaxin 1A ablated mouse model

Cell Reports
Summary: Syntaxin-1A (stx1a) repression causes a neurodevelopmental disorder phenotype, low latent inhibition (LI) behavior, by disrupting 5-hydroxytryptaminergic (5-HTergic) systems. Herein, we discovered that lysine acetyltransferase (KAT) 3B increases
Takahiro Nakayama, Akash K. Singh, Toshiyuki Fukutomi, Noriyuki Uchida, Yasuo Terao, Hiroki Hamada, Takahiro Muraoka, Eswaramoorthy Muthusamy, Tapas K. Kundu, Kimio Akagawa   +9 more
doaj   +1 more source

Two Faces of NOTCH1 in Childhood Lymphoblastic T‐Cell Neoplasia: Prognostic Divergence of Mutational and Structural Aberrations

Pediatric Blood &Cancer, EarlyView.
ABSTRACT In pediatric patients, T‐cell lymphoblastic lymphoma (T‐LBL) survival exceeds 80%. Relapse remains associated with limited curative options. Frontline treatment is largely extrapolated from T‐cell acute lymphoblastic leukemia (T‐ALL) treatment, reflecting the ongoing debate, whether both entities represent distinct diseases or variants within ...
Marie C. Heider, Amelie Alfert, Marc Hotfilder, Birgit Burkardt, Marcel te Vrugt   +4 more
wiley   +1 more source

Scenarios of domain pattern formation in a reaction-diffusion system

, 1996
We performed an extensive numerical study of a two-dimensional reaction-diffusion system of the activator-inhibitor type in which domain patterns can form.
A. Hagberg, A. Hagberg, A. N. Zaikin, A. S. Mikhailov, B. S. Kerner, B. S. Kerner, B. S. Kerner, B. S. Kerner, C. B. Muratov, C. B. Muratov, C. B. Muratov, D. Haim, E. Ammelt, G. Nicolis, I. Lengyel, J. D. Murray, K. J. Lee, K. J. Lee, K. Krischer, K. Lee, M. Bode, M. Cross, M. Gorman, M. Gorman, M. Gorman, M. Seul, P. C. Fife, P. Ortoleva, R. C. Casten, R. E. Goldstein, R. F. Mamin, T. Ohta, T. Ohta, T. Ohta, V. A. Vasiliev, V. V. Osipov, V. V. Osipov, V. V. Osipov   +37 more
core   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Blood levels of histone-complexed DNA fragments are associated with coagulopathy, inflammation and endothelial damage early after trauma

Journal of Emergencies, Trauma and Shock, 2013
Background: Tissue injury increases blood levels of extracellular histones and nucleic acids, and these may influence hemostasis, promote inflammation and damage the endothelium. Trauma-induced coagulopathy (TIC) may result from an endogenous response to
Pär I Johansson, Nis A Windeløv, Lars S Rasmussen, Anne Marie Sørensen, Sisse R Ostrowski   +4 more
doaj   +1 more source

Global Solutions for an -Component System of Activator-Inhibitor Type

Abstract and Applied Analysis, 2013
This paper deals with a reaction-diffusion system with fractional reactions modeling -substances into interaction following activator-inhibitor's scheme. The existence of global solutions is obtained via a judicious Lyapunov functional that generalizes the one introduced by Masuda and Takahashi.
Salem Abdelmalek, Abdelouahab Gouadria, A. Youkana   +2 more
openaire   +4 more sources

Self-replication and splitting of domain patterns in reaction-diffusion systems with fast inhibitor

, 1996
An asymptotic equation of motion for the pattern interface in the domain-forming reaction-diffusion systems is derived. The free boundary problem is reduced to the universal equation of non-local contour dynamics in two dimensions in the parameter region
A. Hagberg, A. Hagberg, B. S. Kerner, B. S. Kerner, B. S. Kerner, C. B. Muratov, C. B. Muratov, E. Ammelt, I. R. Epstein, J. D. Murray, K. Lee, K. M. Mayer, M. Cross, M. Seul, R. E. Goldstein, T. Ohta, T. Ohta, T. Ohta, T. Ohta, V. A. Vasiliev   +19 more
core   +1 more source

On a model mechanism for the spatial patterning of teeth primordia in the Alligator [PDF]

, 1996
We propose a model mechanism for the initiation and spatial positioning of teeth primordia in the alligator,Alligator mississippiensis. Detailed embryological studies by Westergaard & Ferguson (1986, 1987, 1990) show that jaw growth plays a crucial role ...
Cruywagen, G. C., Ferguson, M. W. J., Kulesa, P. M., Lubkin, S. R., Maini, P. K., Murray, J. D., Sneyd, J. S.   +6 more
core   +2 more sources

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Acute exercise-induced changes in hemostatic and fibrinolytic properties: analogies, similarities, and differences between normotensive subjects and patients with essential hypertension

Platelets, 2019
Following acute exercise, normotensive and hypertensive subjects both undergo changes in hemostatic and fibrinolytic properties, but the hypertensive patient’s response to exercise is exaggerated and prolonged, exposing them to increased cardiovascular ...
Annabella Braschi
doaj   +1 more source