Results 71 to 80 of about 341,650 (296)

Modelling cell movement and chemotaxis pseudopod based feedback [PDF]

, 2011
A computational framework is presented for the simulation of eukaryotic cell migration and chemotaxis. An empirical pattern formation model, based on a system of non-linear reaction-diffusion equations, is approximated on an evolving cell boundary using ...
Insall, Robert H., Mackenzie, John, Neilson, Matthew Paterson, Webb, Steven   +3 more
core   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

A priori estimates of stationary solutions of an activator-inhibitor system [PDF]

Indiana University Mathematics Journal, 2007
We consider positive solutions of the stationary Gierer-Meinhardt system. Under suitable conditions on the exponents $p,q,r$ and $s$, different types of a priori estimates are obtained, existence and non-existence results of nontrivial solutions are derived, for both positive and zero source production cases.
Jiang, Huiqiang, Ni, Wei-Ming
openaire   +2 more sources

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

PD-1 inhibition in patient derived tissue cultures of human gastric and gastroesophageal adenocarcinoma

OncoImmunology, 2021
Emerging immunotherapies quest for better patient stratification in cancer treatment decisions. Moderate response rates of PD-1 inhibition in gastric and esophagogastric junction cancers urge for meaningful human model systems that allow for ...
Marlon Hußtegge, Ngoc Anh Hoang, Jakob Rebstock, Astrid Monecke, Ines Gockel, Arved Weimann, Guido Schumacher, Ingo Bechmann, Florian Lordick, Sonja Kallendrusch, Justus Körfer   +10 more
doaj   +1 more source

General theory of instabilities for patterns with sharp interfaces in reaction-diffusion systems

, 1996
An asymptotic method for finding instabilities of arbitrary $d$-dimensional large-amplitude patterns in a wide class of reaction-diffusion systems is presented. The complete stability analysis of 2- and 3-dimensional localized patterns is carried out. It
A. Gierer, A. Hagberg, A. Hagberg, A. Ito, B. N. Belintsev, B. S. Kerner, B. S. Kerner, B. S. Kerner, B. S. Kerner, B. S. Kerner, B. S. Kerner, B. S. Kerner, B. S. Kerner, B. S. Kerner, B. S. Kerner, B. S. Kerner, B. S. Kerner, B. S. Kerner, B. S. Kerner, C. B. Muratov, C. Elphick, D. M. Petrich, E. M. Kuznetsova, F. J. Niedernostheide, G. A. Klaasen, G. B. Ermentrout, H. Willebrand, H. Willebrand, J. E. Pearson, J. Nagumo, J. Rinzel, K. J. Lee, K. J. Lee, K. Krischer, K. Lee, M. Bode, M. Cross, M. Mimura, P. G. FitzHugh, P. Gray, R. C. Casten, S. Koga, T. Ohta, V. V. Osipov, V. V. Osipov, Y. Nishiura, Y. Nishiura   +46 more
core   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Widespread biochemical reaction networks enable Turing patterns without imposed feedback

Nature Communications
Understanding self-organized pattern formation is fundamental to biology. In 1952, Alan Turing proposed a pattern-enabling mechanism in reaction-diffusion systems containing chemical species later conceptualized as activators and inhibitors that are ...
Shibashis Paul, Joy Adetunji, Tian Hong
doaj   +1 more source

Waves and patterning in developmental biology: vertebrate segmentation and feather bud formation as case studies [PDF]

, 2009
In this article we will discuss the integration of developmental patterning mechanisms with waves of competency that control the ability of a homogeneous field of cells to react to pattern forming cues and generate spatially heterogeneous patterns.
Baker, Ruth E., Maini, P. K., Schnell, S.   +2 more
core   +3 more sources

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source