Results 71 to 80 of about 10,333,992 (256)

Prediction of life quality based on Behavioral Activator-Inhibitor Systems and adulthood hyperactivity in male drug abusers

فصلنامه روان‌شناسی کاربردی, 2019
Aim: The aim of this research was to predict life quality based on behavioral activator and inhibitor systems and adulthood hyperactivity in male drug abusers. Method: A correlational method was employed. The statistical population consisted of 1637 drug
معصومه شاه محمدی, صادق تقی لو   +1 more
doaj  

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Turing pattern dynamics in an activator-inhibitor system with superdiffusion

, 2014
The fractional operator is introduced to an activator-inhibitor system to describe species anomalous superdiffusion. The effects of the superdiffusive exponent on pattern formation and pattern selection are studied.
Zhang, Lai,, Tian, Canrong
core   +1 more source

Physical interactions enable energy-efficient Turing patterns

Physical Review Research
Patterns are ubiquitous in nature, but how they form is often unclear. Turing developed a seminal theory to explain patterns based on reactions that counteract the equalizing tendency of diffusion.
Cathelijne ter Burg, David Zwicker
doaj   +1 more source

SARS-COV-2 causes significant abnormalities in the fibrinolysis system of patients: correlation between viral mutations, variants and thrombosis

Frontiers in Cellular and Infection Microbiology
BackgroundCoronavirus disease (COVID-19) is reported as a complex disorder affecting multiple systems and coagulopathy that can cause mortality. In this study, we investigated the correlation of SARS-CoV-2 mutations found in blood samples with various ...
Esra’a Abudouleh, Tarek Owaidah, Tarek Owaidah, Fatimah Alhamlan, Fatimah Alhamlan, Arwa A. Al-Qahtani, Reem M. Aljowaie, Fatimah Al-Ghnnam, Marie Fe Bohol, Ahmed A. Al-Qahtani, Ahmed A. Al-Qahtani   +10 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

2-Aminoethoxydiphenyl borate activates the human mechano-gated KCNK channels KCNK 2 (TREK-1), KCNK 4 (TRAAK) and KCNK 10 (TREK-2).

Frontiers in Pharmacology, 2013
: Two-pore domain K+ (KCNK, K2P) channels underlie the leak (background) potassium conductance in many types of excitable cells. They oppose membrane depolarization and cell excitability.
Leopoldo Raul Beltran, Madeline eBeltran, Ainhara eAguado, Guenter eGisselmann, Hanns eHatt   +4 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source