Results 91 to 100 of about 341,650 (296)

Bifurcation analysis of a normal form for excitable media: Are stable dynamical alternans on a ring possible?

, 2008
We present a bifurcation analysis of a normal form for travelling waves in one-dimensional excitable media. The normal form which has been recently proposed on phenomenological grounds is given in form of a differential delay equation.
Georg A. Gottwald, Guevara M. R., Krasovskii N., Mines G. R., Verhulst F., Winfree A. T.   +5 more
core   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Physical interactions enable energy-efficient Turing patterns

Physical Review Research
Patterns are ubiquitous in nature, but how they form is often unclear. Turing developed a seminal theory to explain patterns based on reactions that counteract the equalizing tendency of diffusion.
Cathelijne ter Burg, David Zwicker
doaj   +1 more source

SARS-COV-2 causes significant abnormalities in the fibrinolysis system of patients: correlation between viral mutations, variants and thrombosis

Frontiers in Cellular and Infection Microbiology
BackgroundCoronavirus disease (COVID-19) is reported as a complex disorder affecting multiple systems and coagulopathy that can cause mortality. In this study, we investigated the correlation of SARS-CoV-2 mutations found in blood samples with various ...
Esra’a Abudouleh, Tarek Owaidah, Tarek Owaidah, Fatimah Alhamlan, Fatimah Alhamlan, Arwa A. Al-Qahtani, Reem M. Aljowaie, Fatimah Al-Ghnnam, Marie Fe Bohol, Ahmed A. Al-Qahtani, Ahmed A. Al-Qahtani   +10 more
doaj   +1 more source

Neural network computation by in vitro transcriptional circuits [PDF]

, 2004
The structural similarity of neural networks and genetic regulatory networks to digital circuits, and hence to each other, was noted from the very beginning of their study [1, 2]. In this work, we propose a simple biochemical system whose architecture
Hopfield, John J., Kim, Jongmin, Winfree, Erik   +2 more
core  

The large core limit of spiral waves in excitable media: A numerical approach

, 2010
We modify the freezing method introduced by Beyn & Thuemmler, 2004, for analyzing rigidly rotating spiral waves in excitable media. The proposed method is designed to stably determine the rotation frequency and the core radius of rotating spirals, as ...
Fiedler B., Georg A. Gottwald, Sandstede B., Sebastian Hermann, Wiener N.   +4 more
core   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Finite-time blowup of solutions to some activator-inhibitor systems

Discrete and Continuous Dynamical Systems, 2016
The authors look into the dynamics of solutions to a reaction-diffusion system modeling a class of bio-pattern formation. This model has activator-inhibitor type nonlinearities. The authors point out that the system has solutions blowing up in finite time in both space-homogeneous and space non-homogeneous cases.
Karch, Grzegorz, Suzuki, Kanako, Zienkiewicz, Jacek   +2 more
openaire   +1 more source

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source