Results 91 to 100 of about 234,823 (303)

Diversity of matriptase expression level and function in breast cancer [PDF]

, 2011
This work was funded by Cancer Research UK Program Grant (C157/A9148).Overexpression of matriptase has been reported in a variety of human cancers and is sufficient to trigger tumor formation in mice, but the importance of matriptase in breast cancer ...
Sproul, Duncan, Muir, Morwenna, Peter Mullen (171093), Faratian Dana, Brunton, Valerie G, Morwenna Muir, Brunton Valerie G., Dana Faratian (171110), Muir, Morwenna; id_orcid, Frame, Margaret C., David J. Harrison (171106), Muir Morwenna, Dana Faratian, Valerie G Brunton, Andrew R Kinnaird, Andrew R. Kinnaird (171104), Valerie G. Brunton, Brunton, Valerie G., Kinnaird, Andrew R., Duncan Sproul, Morwenna Muir (171098), David J. Harrison, Harrison David J., Frame, Margaret C, Duncan Sproul (3186), Sproul Duncan, Andrew R. Kinnaird, Arkadiusz Welman (171085), Kinnaird Andrew R., Harrison, David J, Arkadiusz Welman, Margaret C Frame, David J Harrison, Faratian, Dana, Mullen, Peter, Margaret C. Frame (171119), Kinnaird, Andrew R, Welman Arkadiusz, Frame Margaret C., Welman, Arkadiusz, Margaret C. Frame, Mullen Peter, Valerie G. Brunton (171114), Peter Mullen, Harrison, David J.   +44 more
core   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Staphylococcus aureus proteins Sbi and Efb recruit human plasmin to degrade complement C3 and C3b

, 2012
Upon host infection, the human pathogenic microbe Staphylococcus aureus (S. aureus) immediately faces innate immune reactions such as the activated complement system. Here, a novel innate immune evasion strategy of S. aureus is described.
Peter F. Zipfel, Christine Skerka, Kraiczy, Peter, Michael Reuter, Reuter, Michael, Skerka, Christine, Barthel, Diana, Diana Barthel, Koch, Tina K., Elsen, Jean van den, Böhm, Sascha, Zipfel, Peter F., Jean van den Elsen, Peter Kraiczy, Tina K Koch, Sascha Böhm, Peter F Zipfel, Tina K. Koch   +17 more
core   +1 more source

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

Global existence of solutions of an activator-inhibitor system

Discrete and Continuous Dynamical Systems, 2006
We consider the generalized Gierer-Meinhardt system $\frac{\partial u_{j}}{\partial t}=d_{j}$Δ $u_{j}- a_{j}u_{j} +g_{j}(x,u) \ \ \text{in}\ \ \Omega\times[0,T) $ , $\frac{\partial u_{j}}{\partial\nu}=0\ \ \text{on}\ \ \partial\Omega\times[ 0,T) $, $u_{j}(x,0) =\varphi_{j}(x)\ \ \text{in}\ \ \Omega$ where $\Omega$ is a smooth ...
openaire   +1 more source

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

FEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara, Kinga Skoczek, Elzbieta Pyza, Milena Damulewicz   +3 more
wiley   +1 more source

Spherically symmetric internal layers for activator–inhibitor systems II. Stability and symmetry breaking bifurcations

, 2004
A reaction-diffusion system of activator–inhibitor type is studied on an N-dimensional ball with the homogeneous Neumann boundary conditions. We analyze the stability property of the spherically symmetric solutions and their symmetry-breaking ...
Suzuki, Hiromasa, Sakamoto, Kunimochi
core   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

TRIM68 negatively regulates IFN-β production by degrading TRK fused gene, a novel driver of IFN-β downstream of anti-viral detection systems.

PLoS ONE, 2014
In recent years members of the tripartite motif-containing (TRIM) family of E3 ubiquitin ligases have been shown to both positively and negatively regulate viral defence and as such are emerging as compelling targets for modulating the anti-viral immune ...
Claire Wynne, Elisa Lazzari, Siobhán Smith, Eoghan M McCarthy, Joan Ní Gabhann, Lara E Kallal, Rowan Higgs, Angela Greco, Sally Ann Cryan, Christine A Biron, Caroline A Jefferies   +10 more
doaj   +1 more source