Results 11 to 20 of about 10,333,992 (256)

Impaired Fibrinolysis in the Pathogenesis of Dengue Hemorrhagic Fever [PDF]

, 2002
The mechanisms contributing to bleeding complications in dengue hemorrhagic fever were studied by investigating the pattern of activation of the coagulation and fibrinolytic systems in 50 children with severe dengue hemorrhagic fever.
ten Cate, H, Brandjes, DPM, Hack, C. Erik, Mairuhu, ATA, van der Meer, Jos W. M., Dolmans, Wil M. V., Suharti, Catharina, van Gorp, Eric C. M., Setiati, Tatty E.   +8 more
core   +2 more sources

Diffusivity estimation for activator-inhibitor models [PDF]

, 2021
A theory for diffusivity estimation for spatially extended activator-inhibitor dynamics modeling the evolution of intracellular signaling networks is developed in the mathematical framework of stochastic reaction-diffusion systems.
Stannat, Wilhelm, Pasemann, Gregor (Dr. rer. nat.), Alonso, Sergio, Beta, Carsten (Prof. Dr.), Flemming, Sven (Dr. rer. n.)   +4 more
core   +2 more sources

Effect of dsRNA on Mesangial Cell Synthesis of Plasminogen Activator Inhibitor Type 1 and Tissue Plasminogen Activator [PDF]

, 2009
Background/Aims: Viral infections are a major problem worldwide and many of them are complicated by virally induced glomerulonephritides. Progression of kidney disease to renal failure is mainly attributed to the development of renal fibrosis ...
Wörnle, Markus, Merkle, Monika, Sauter, Matthias, Ribeiro, Andrea, Roeder, Maximilian   +4 more
core   +1 more source

Novel bi- and trifunctional inhibitors of tumor-associated proteolytic systems [PDF]

, 2003
Serine proteases, cysteine proteases, and matrix metalloproteinases (MMPs) are involved in cancer cell invasion and metastasis. Recently, a recombinant bifunctional inhibitor (chCysuPA(19-31)) directed against cysteine proteases and the urokinasetype ...
Sato, Sumito, Assfalg-Machleidt, Irmgard, Magdolen, Ulla, Schmitt, Manfred, Rettenberger, Peter, Magdolen, Viktor, Krol, Janna   +6 more
core   +1 more source

The occurrence of prime numbers revisited

GECONTEC: Revista Internacional de Gestión del Conocimiento y la Tecnología, 2016
Based on an arithmetical and autocatalytic approach, the authors propose a solution for the occurrence of prime numbers. Exact arithmetical calculations are provided for: the closest prime to any given positive integer (or any number of bigger or smaller
Ernesto Tapia Moore, José Tapia Yañez
doaj   +4 more sources

Increased PAI-1 plasma levels and risk of death from dengue: no association with the 4G/5G promoter polymorphism [PDF]

, 2005
Background: Dengue virus infected patients have high plasminogen activator inhibitor type I (PAI-1) plasma concentrations. Whether the insertion/deletion (4G/5G) polymorphism in the promotor region of the PAI-1 gene is associated with increased PAI-1 ...
ten Cate, H, Brandjes, DPM, Leyte, A, Osterhaus, A.D.M.E. (Albert), Koraka, P. (Penelope), Brandjes, D.P.M. (Dees), Mairuhu, A.T., ten Cate H, Brandjes, D.P., SMH Faradz, Faradz, S.M.H., van Gorp, E., Hack, C. Erik, Setiati, T., Brandjes DPM, Mairuhu, ATA, Osterhaus ADME, Reitsma, PH, Osterhaus, A.D.M.E., Faradz, SMH, Faradz SMH, Gorp, E. van, Faradz, Sultana M.H., Setiati, T.E. (Tatty), Brandjes, D.P.M., Osterhaus, A.D., Setiati, Tatty E., van Gorp, E.C.M., Cate, H. (Hugo) ten, Koraka, P., Reitsma PH, van Gorp, Eric, Mairuhu, A.T.A., Mairuhu ATA, Reitsma, P., ECM van Gorp, Koraka, Penelopie, Reitsma, P.H., A Leyte, Setiati, TE, van Gorp, Eric C. M., Setiati TE, Osterhaus, Ab, Koraka, P, Leyte A, H ten Cate, ADME Osterhaus, Hack CE, PH Reitsma, Setiati, T.E., Hack, C.E., Osterhaus, ADME, CE Hack, van Gorp ECM, ATA Mairuhu, Osterhaus, A., TE Setiati, Koraka P, Leyte, A. (Anja), P Koraka, Mairuhu, A., Faradz, S.M.H. (Sultana), Gorp, E.C.M. (Eric) van, Hack, CE, DPM Brandjes, Hack, C., Faradz, S., Hack, C.E. (Erik), Leyte, A., Cate, H. ten, ten Cate, H.   +70 more
core   +2 more sources

Turing patterns in network-organized activator–inhibitor systems [PDF]

, 2010
Turing instability in activator-inhibitor systems provides a paradigm of nTuring instability in activator-inhibitor systems provides a paradigm of non-equilibrium self-organization; it has been extensively investigated for biological and chemical ...
Alexander S. Mikhailov, Mikhailov, A., Nakao, H., Hiroya Nakao   +3 more
core   +1 more source

Functional Modulation of Gene Expression by Ultraconserved Long Non-coding RNA TUC338 during Growth of Human Hepatocellular Carcinoma

iScience, 2018
Summary: TUC338 is an ultraconserved long non-coding RNA that contributes to transformed cell growth in hepatocellular carcinoma (HCC). Genomic regions of TUC338 occupancy were enriched in unique or known binding motifs homologous to the tumor ...
Hui-Ju Wen, Michael P. Walsh, Irene K. Yan, Kenji Takahashi, Alan Fields, Tushar Patel   +5 more
doaj   +1 more source

Two MYB Proteins in a Self-Organizing Activator-Inhibitor System Produce Spotted Pigmentation Patterns [PDF]

, 2020
Many organisms exhibit visually striking spotted or striped pigmentation patterns. Developmental models predict that such spatial patterns can form when a local autocatalytic feedback loop and a long-range inhibitory feedback loop interact.
Holalu, Srinidhi V, Greenlee, Anna B, Johnson, Grace A, Bradshaw, HD, Patterson, Erin L, Stanley, Lauren E, Ding, Baoqing, Yuan, Yao-Wu, Li, Jingjian, Peng, Foen, Blackman, Benjamin K, Blinov, Michael L   +11 more
core   +1 more source

Oncogenic TYK2 P760L kinase is effectively targeted by combinatorial TYK2, mTOR and CDK4/6 kinase blockade

Haematologica, 2022
Tyrosine kinase 2 (TYK2) is a member of the Janus kinase/signal transducer and activator of transcription pathway, which is central in cytokine signaling.
Katharina Woess, Sabine Macho-Maschler, Dorette S. van Ingen Schenau, Miriam Butler, Caroline Lassnig, Daniel Valcanover, Andrea Poelzl, Katrin Meissl, Barbara Maurer, Tania Brandstoetter, Claus Vogl, Anna Koren, Stefan Kubicek, Anna Orlova, Richard Moriggl, Birgit Strobl, Veronika Sexl, Frank N. van Leeuwen, Roland P. Kuiper, Mathias Mueller   +19 more
doaj   +1 more source