Results 231 to 240 of about 3,917,874 (426)

P3247Polymorphisms of the ALOX5AP gene (5-lipoxygenase activating protein) are associated with increased cardiovascular risk in patients with acute coronary syndrome: Analysis of PLATO genetics sub-study [PDF]

, 2017
Clare A. Balendran, Niclas Eriksson, Carl Whatling, Anna Walentinsson, Stanko Skrtic, Axel Åkerblom, Karin Jensevik, Lars Wallentin   +7 more
openalex   +1 more source

Identification of recurrent NAB2-STAT6 gene fusions in solitary fibrous tumor by integrative sequencing

Nature Genetics, 2013
D. Robinson, Yi-Mi Wu, Shanker Kalyana-Sundaram, Xuhong Cao, R. Lonigro, Yun‐Shao Sung, Chun‐Liang Chen, Lei Zhang, Rui Wang, Fengyun Su, M. Iyer, S. Roychowdhury, J. Siddiqui, K. Pienta, L. Kunju, M. Talpaz, J. Mosquera, S. Singer, S. Schuetze, C. Antonescu, A. Chinnaiyan   +20 more
semanticscholar   +1 more source

The atypical KRASQ22K mutation directs TGF‐β response towards partial epithelial‐to‐mesenchymal transition in patient‐derived colorectal cancer tumoroids

Molecular Oncology, EarlyView.
TGF‐β has a complex role in cancer, exhibiting both tumor‐suppressive and tumor‐promoting properties. Using a series of differentiated tumoroids, derived from different stages and mutational background of colorectal cancer patients, we replicate this duality of TGF‐β in vitro. Notably, the atypical but highly aggressive KRASQ22K mutation rendered early‐
Theresia Mair, Philip König, Milena Mijović, Jessica Kalla, Anil Baskan, Loan Tran, Kristina Draganić, Pedro Morata Saldaña, Carlos Uziel Pérez Malla, Janette Pfneissl, Andreas Tiefenbacher, Julijan Kabiljo, Velina S. Atanasova, Lisa Wozelka‐Oltjan, Leonhard Müllauer, Michael Bergmann, Raheleh Sheibani‐Tezerji, Gerda Egger   +17 more
wiley   +1 more source

Expression analysis of protein inhibitor of activated STAT (PIAS) genes in IFNβ-treated multiple sclerosis patients

Journal of Inflammation Research, 2018
Mohammad Taheri,1,* Ghazaleh Azimi,2,* Arezou Sayad,2 Mehrdokht Mazdeh,3 Shahram Arsang-Jang,4,5 Mir Davood Omrani,5 Soudeh Ghafori-Fard2 1Student Research Committee, Shahid Beheshti University of Medical Sciences, Tehran, Iran; 2Department of Medical ...
Taheri M, Azimi G, Sayad A, Mazdeh M, Arsang-Jang S, Omrani MD, Ghafouri-Fard S   +6 more
doaj  

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

Molecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser, Florian Krumbach, Eyleen Corrales, Geoffroy Andrieux, Christian Preisinger, Franziska Liss, Alexandra Golzmann, Melanie Boerries, Kerstin Becker, Ruth Knüchel, Stefan Garczyk, Bernhard Lüscher   +11 more
wiley   +1 more source

Escape from TGF‐β‐induced senescence promotes aggressive hallmarks in epithelial hepatocellular carcinoma cells

Molecular Oncology, EarlyView.
Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu, Dilara Demirci, Sude Eris, Bengisu Dayanc, Ece Cakiroglu, Merve Basol, Merve Uysal, Gulcin Cakan‐Akdogan, Fang Liu, Mehmet Ozturk, Gökhan Karakülah, Serif Senturk   +11 more
wiley   +1 more source

Chemical Genetics Identifies c-Src as an Activator of Primitive Ectoderm Formation in Murine Embryonic Stem Cells [PDF]

, 2009
Malcolm A. Meyn, Thomas E. Smithgall
openalex   +1 more source

Genetic toxicology and genetically active environmental factors

International Journal of Biology and Chemistry, 2018
A. I. Zhussupova, Rinat Islamov, A. Aitynova   +2 more
openaire   +2 more sources

ShcD adaptor protein drives invasion of triple negative breast cancer cells by aberrant activation of EGFR signaling

Molecular Oncology, EarlyView.
We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau, Hayley S. Smith, Begüm Alural, Claire E. Martin, Laura A. New, Manali Tilak, Sara L. Banerjee, Hannah N. Robeson, Nicolas Bisson, Anne‐Claude Gingras, Jasmin Lalonde, Nina Jones   +11 more
wiley   +1 more source

Combinatorial genetics in liver repopulation and carcinogenesis with a in vivo CRISPR activation platform†

, 2017
Kirk J. Wangensteen, Yue J. Wang, Zhixun Dou, Amber W. Wang, Elham Mosleh‐Shirazi, Max A. Horlbeck, Luke A. Gilbert, Jonathan S. Weissman, Shelley L. Berger, Klaus H. Kaestner   +9 more
openalex   +1 more source