Results 231 to 240 of about 262,173 (350)

Functional Characterization of Glucokinase Variants to Aid Clinical Interpretation of Monogenic Diabetes. [PDF]

Int J Mol Sci
Rajesh V, Ibarra DE, Yang J, Zhang H, Barrett A, Kaplan EG, Kumthekar A, Sunden F, Sun H, Addala A, Misakian A, Letourneau-Freiberg LR, Jodarski CO, Maloney KA, Saint-Martin C, Fordyce PM, Pollin TI, Gloyn AL.   +17 more
europepmc   +1 more source

Identification of inhibitors of auxin transcriptional activation by means of chemical genetics in Arabidopsis

, 2004
Joshua I. Armstrong, Shiaulou Yuan, Joseph M. Dale, Vanessa N. Tanner, Athanasios Theologis   +4 more
openalex   +1 more source

The Relationship between Peroxisome Proliferator-Activated Receptor-γ and Renin: A Human Genetics Study [PDF]

, 2010
Patricia Underwood, Bei Sun, Jonathan S. Williams, Luminita H. Pojoga, Bindu Chamarthi, Jessica Lasky‐Su, Benjamin A. Raby, Paul N. Hopkins, Xavier Jeunemaı̂tre, Nancy J. Brown, Gail K. Adler, Gordon H. Williams   +11 more
openalex   +1 more source

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

Molecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne   +61 more
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

An examination of the quinic acid utilization genes in Aspergillus niger reveals the involvement of 2 pH-dependent permeases. [PDF]

G3 (Bethesda)
Sgro M, Reid ID, Arentshorst M, Ram AFJ, Tsang A.   +4 more
europepmc   +1 more source

The Genetics of Insulin Resistance: Analysis of the Peroxisome Proliferator-Activated Receptor Pathway [PDF]

, 2005
M. Y. Boudreaux
openalex  

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Novel insights into the regulation of NF2/SWH signaling in granulosa cells of prehierarchical follicle development in hen ovary. [PDF]

Poult Sci
Sun X, Qin N, Cao S, Wang S, Sun Y, Ou Y, Yan C, Ma C, Zhao J, Xu R, Mishra B.   +10 more
europepmc   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source