Results 21 to 30 of about 260,779 (356)
Target identification strategies in plant chemical biology [PDF]
, 2014 The current needs to understand gene function in plant biology increasingly require more dynamic and conditional approaches opposed to classic genetic strategies.
Dejonghe, Wim, Russinova, Eugenia
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Genetic Dissection of Antibiotic Adjuvant Activity
mBio, 2022 One strategy to confront the antibiotic resistance crisis is through the development of adjuvant compounds that increase the efficacy of established drugs. A key step in the development of a natural product adjuvant as a drug is identifying the resistance process it undermines to enhance antibiotic activity.
J. Bailey +6 more
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One-two punch mechanism of gene repression: a fresh perspective on gene regulation. [PDF]
, 2017 Cellular differentiation depends on temporally controlled waves of gene activation and inactivation that ultimately transform one cell type into another.
Tresenrider, Amy, Ünal, Elçin
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Genetic analysis of physical activity in twins [PDF]
The American Journal of Clinical Nutrition, 2005 The reduced contribution of physical activity (PA) to daily energy expenditure contributes to the increased prevalence of obesity. A genetic control of activity-induced energy expenditure (AEE) may contribute to a genetic susceptibility to obesity.Our aim was to investigate the relative contribution of genetic and environmental factors to the variation
Klaas R. Westerterp +3 more
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Astonishing advances in mouse genetic tools for biomedical research
Swiss Medical Weekly, 2015 The humble house mouse has long been a workhorse model system in biomedical research. The technology for introducing site-specific genome modifications led to Nobel Prizes for its pioneers and opened a new era of mouse genetics.
Walker Scot Jackson, Lech Kaczmarczyk
doaj +1 more source
Identification and functional study of GATA4 gene regulatory variants in type 2 diabetes mellitus
BMC Endocrine Disorders, 2021 Background Type 2 diabetes mellitus (T2D) is a common and complex disease. Dysfunction of pancreatic β cells, which cannot release sufficient insulin, plays a central role in T2D. Genetics plays a critical role in T2D etiology. Transcription factor GATA4
Liangcai Ding +6 more
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Genetic and Molecular Regulations of Neuronal Activity
International Journal of Molecular Sciences, 2023 This Special Issue of the International Journal of Molecular Sciences (IJMS) focuses on ‘Genetic and Molecular Regulations of Neuronal Activity’ [...]
Marcella Reale +3 more
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Novel Nucleotide Variations, Haplotypes Structure and Associations with Growth Related Traits of Goat AT Motif-Binding Factor () Gene [PDF]
Asian-Australasian Journal of Animal Sciences, 2015 The AT motif-binding factor (ATBF1) not only interacts with protein inhibitor of activated signal transducer and activator of transcription 3 (STAT3) (PIAS3) to suppress STAT3 signaling regulating embryo early development and cell differentiation, but is
Xiaoyan Zhang +7 more
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Use of the Iron-Responsive RBT5 Promoter for Regulated Expression in Candida albicans
mSphere, 2022 Engineered conditional gene expression is used in appraisal of gene function and pathway relationships. For pathogens like the fungus Candida albicans, conditional expression systems are most useful if they are active in the infection environment and if ...
Yinhe Mao +5 more
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Evolutionary processes from the perspective of flowering time diversity. [PDF]
, 2020 Although it is well appreciated that genetic studies of flowering time regulation have led to fundamental advances in the fields of molecular and developmental biology, the ways in which genetic studies of flowering time diversity have enriched the field
Blackman, Benjamin K, Gaudinier, Allison
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