Results 21 to 30 of about 3,963,692 (395)

Singular limit of an activator-inhibitor type model

Networks and Heterogeneous Media, 2012
We consider a reaction-diffusion system of activator-inhibitor type arising in the theory of phase transition. Itappears in biological contexts such as pattern formation in population genetics.
Marie Henry
doaj   +1 more source

Anaplastic large cell lymphoma: pathology, genetics, and clinical aspects.

Journal of Clinical and Experimental Hematopathology, 2017
Anaplastic large cell lymphoma (ALCL) was first described in 1985 as a large-cell neoplasm with anaplastic morphology immunostained by the Ki-1 antibody, which recognizes CD30.
N. Tsuyama, K. Sakamoto, S. Sakata, Akito Dobashi, K. Takeuchi   +4 more
semanticscholar   +1 more source

Identification and characterization of a Mef2 transcriptional activator in schistosome parasites. [PDF]

PLoS Neglected Tropical Diseases, 2012
Myocyte enhancer factor 2 protein (Mef2) is an evolutionarily conserved activator of transcription that is critical to induce and control complex processes in myogenesis and neurogenesis in vertebrates and insects, and osteogenesis in vertebrates.
John N Milligan, Emmitt R Jolly
doaj   +1 more source

Therapeutic targets for inflammatory bowel disease: proteome-wide Mendelian randomization and colocalization analysesResearch in context

EBioMedicine, 2023
Summary: Background: Identifying new drug targets for inflammatory bowel disease (IBD) is urgently needed. The proteome is a major source of therapeutic targets.
Jie Chen, Fengzhe Xu, Xixian Ruan, Jing Sun, Yao Zhang, Han Zhang, Jianhui Zhao, Jie Zheng, Susanna C. Larsson, Xiaoyan Wang, Xue Li, Shuai Yuan   +11 more
doaj   +1 more source

DCA1 Acts as a Transcriptional Co-activator of DST and Contributes to Drought and Salt Tolerance in Rice

PLoS Genetics, 2015
Natural disasters, including drought and salt stress, seriously threaten food security. In previous work we cloned a key zinc finger transcription factor gene, Drought and Salt Tolerance (DST), a negative regulator of drought and salt tolerance that ...
Longgang Cui, Jun-Xiang Shan, Min Shi, Ji-Ping Gao, Hong-Xuan Lin   +4 more
semanticscholar   +1 more source

Genetic Dissection of Antibiotic Adjuvant Activity

mBio, 2022
One strategy to confront the antibiotic resistance crisis is through the development of adjuvant compounds that increase the efficacy of established drugs. A key step in the development of a natural product adjuvant as a drug is identifying the resistance process it undermines to enhance antibiotic activity.
J. Bailey, L. Gallagher, W. T. Barker, V. B. Hubble, J. Gasper, C. Melander, C. Manoil   +6 more
openaire   +3 more sources

The Overlapping and Distinct Roles of HAM Family Genes in Arabidopsis Shoot Meristems

Frontiers in Plant Science, 2020
In Arabidopsis shoot apical meristems (SAMs), a well-characterized regulatory loop between WUSCHEL (WUS) and CLAVATA3 (CLV3) maintains stem cell homeostasis by regulating the balance between cell proliferation and cell differentiation.
Han Han, Han Han, Yuan Geng, Yuan Geng, Lei Guo, Lei Guo, An Yan, An Yan, Elliot M. Meyerowitz, Elliot M. Meyerowitz, Xing Liu, Xing Liu, Yun Zhou, Yun Zhou   +13 more
doaj   +1 more source

The Cryptococcus neoformans Alkaline Response Pathway: Identification of a Novel Rim Pathway Activator

PLoS Genetics, 2015
The Rim101/PacC transcription factor acts in a fungal-specific signaling pathway responsible for sensing extracellular pH signals. First characterized in ascomycete fungi such as Aspergillus nidulans and Saccharomyces cerevisiae, the Rim/Pal pathway ...
Kyla S. Ost, T. O. O 'meara, Naureen Huda, Shannon K Esher, J. Alspaugh, D. Davis   +5 more
semanticscholar   +1 more source

Sexual Dimorphism in Osteoclasts

Cells, 2020
Osteoclasts are the principal mediators of bone resorption. They form through the fusion of mononuclear precursor cells under the principal influence of the cytokines macrophage colony stimulating factor (M-CSF, aka CSF-1) and receptor activator of NF-κB
Joseph Lorenzo
doaj   +1 more source

Use of the Iron-Responsive RBT5 Promoter for Regulated Expression in Candida albicans

mSphere, 2022
Engineered conditional gene expression is used in appraisal of gene function and pathway relationships. For pathogens like the fungus Candida albicans, conditional expression systems are most useful if they are active in the infection environment and if ...
Yinhe Mao, Norma V. Solis, Anupam Sharma, Max V. Cravener, Scott G. Filler, Aaron P. Mitchell   +5 more
doaj   +1 more source