Results 31 to 40 of about 3,917,874 (426)
Resveratrol, an activator of SIRT1, upregulates AMPK and improves cardiac function in heart failure.
Genetics and Molecular Research, 2014 Reduced AMP-activated protein kinase (AMPK) expression has been shown to play a significant role in the cardiac dysfunction in heart failure. This study was designed to examine the effect of resveratrol, a potent activator of silent information regulator
X. Gu +6 more
semanticscholar +1 more source
Novel Nucleotide Variations, Haplotypes Structure and Associations with Growth Related Traits of Goat AT Motif-Binding Factor () Gene [PDF]
Asian-Australasian Journal of Animal Sciences, 2015 The AT motif-binding factor (ATBF1) not only interacts with protein inhibitor of activated signal transducer and activator of transcription 3 (STAT3) (PIAS3) to suppress STAT3 signaling regulating embryo early development and cell differentiation, but is
Xiaoyan Zhang +7 more
doaj +1 more source
Known allosteric proteins have central roles in genetic disease [PDF]
, 2021 Allostery is a form of protein regulation, where ligands that bind sites located apart from the active site can modify the activity of the protein. The molecular mechanisms of allostery have been extensively studied, because allosteric sites are less conserved than active sites, and drugs targeting them are more specific than drugs binding the active ...
arxiv +1 more source
Identification and functional study of GATA4 gene regulatory variants in type 2 diabetes mellitus
BMC Endocrine Disorders, 2021 Background Type 2 diabetes mellitus (T2D) is a common and complex disease. Dysfunction of pancreatic β cells, which cannot release sufficient insulin, plays a central role in T2D. Genetics plays a critical role in T2D etiology. Transcription factor GATA4
Liangcai Ding +6 more
doaj +1 more source
Genetic analysis of physical activity in twins [PDF]
The American Journal of Clinical Nutrition, 2005 The reduced contribution of physical activity (PA) to daily energy expenditure contributes to the increased prevalence of obesity. A genetic control of activity-induced energy expenditure (AEE) may contribute to a genetic susceptibility to obesity.Our aim was to investigate the relative contribution of genetic and environmental factors to the variation
Klaas R. Westerterp +3 more
openaire +3 more sources
Biochemical Journal, 2001 Protein phosphatase 2A (PP2A) comprises a family of serine/threonine phosphatases, minimally containing a well conserved catalytic subunit, the activity of which is highly regulated.
V. Janssens, J. Goris
semanticscholar +1 more source
Target identification strategies in plant chemical biology [PDF]
, 2014 The current needs to understand gene function in plant biology increasingly require more dynamic and conditional approaches opposed to classic genetic strategies.
Dejonghe, Wim, Russinova, Eugenia
core +2 more sources
Genetic and Molecular Regulations of Neuronal Activity
International Journal of Molecular Sciences, 2023 This Special Issue of the International Journal of Molecular Sciences (IJMS) focuses on ‘Genetic and Molecular Regulations of Neuronal Activity’ [...]
Marcella Reale +3 more
openaire +3 more sources
Astonishing advances in mouse genetic tools for biomedical research
Swiss Medical Weekly, 2015 The humble house mouse has long been a workhorse model system in biomedical research. The technology for introducing site-specific genome modifications led to Nobel Prizes for its pioneers and opened a new era of mouse genetics.
Walker Scot Jackson, Lech Kaczmarczyk
doaj +1 more source
PLoS Genetics, 2014 Mitogen-activated protein kinase (MAPK) pathways are crucial signaling instruments in eukaryotes. Most ascomycetes possess three MAPK modules that are involved in key developmental processes like sexual propagation or pathogenesis.
I. Teichert +6 more
semanticscholar +1 more source