Results 31 to 40 of about 3,963,692 (395)
The role of Schizosaccharomyces pombe SUMO ligases in genome stability [PDF]
, 2007 SUMOylation is a post-translational modification that affects a large number of proteins, many of which are nuclear. While the role of SUMOylation is beginning to be elucidated, it is clear that understanding the mechanisms that regulate the process is ...
A. Skilton +44 more
core +2 more sources
Reaction diffusion processes on random and scale-free networks [PDF]
, 2004 We study the discrete Gierer-Meinhardt model of reaction-diffusion on three different types of networks: regular, random and scale-free. The model dynamics lead to the formation of stationary Turing patterns in the steady state in certain parameter ...
De Wit A. +4 more
core +2 more sources
Astonishing advances in mouse genetic tools for biomedical research
Swiss Medical Weekly, 2015 The humble house mouse has long been a workhorse model system in biomedical research. The technology for introducing site-specific genome modifications led to Nobel Prizes for its pioneers and opened a new era of mouse genetics.
Walker Scot Jackson, Lech Kaczmarczyk
doaj +1 more source
Identification and functional study of GATA4 gene regulatory variants in type 2 diabetes mellitus
BMC Endocrine Disorders, 2021 Background Type 2 diabetes mellitus (T2D) is a common and complex disease. Dysfunction of pancreatic β cells, which cannot release sufficient insulin, plays a central role in T2D. Genetics plays a critical role in T2D etiology. Transcription factor GATA4
Liangcai Ding +6 more
doaj +1 more source
Genetic strategies to access activated neurons [PDF]
Current Opinion in Neurobiology, 2017 A major goal of modern neuroscience is to understand how ensembles of neurons participate in neural circuits underlying behavior. The recent explosion of genetically-encoded circuit analysis tools has allowed neuroscientists to characterize molecularly-defined neuronal types with unprecedented detail.
Laura, DeNardo, Liqun, Luo
openaire +2 more sources
Novel Nucleotide Variations, Haplotypes Structure and Associations with Growth Related Traits of Goat AT Motif-Binding Factor () Gene [PDF]
Asian-Australasian Journal of Animal Sciences, 2015 The AT motif-binding factor (ATBF1) not only interacts with protein inhibitor of activated signal transducer and activator of transcription 3 (STAT3) (PIAS3) to suppress STAT3 signaling regulating embryo early development and cell differentiation, but is
Xiaoyan Zhang +7 more
doaj +1 more source
Evolution of asexual and sexual reproduction in the aspergilli [PDF]
, 2018 Aspergillus nidulans has long-been used as a model organism to gain insights into the genetic basis of asexual and sexual developmental processes both in other members of the genus Aspergillus, and filamentous fungi in general.
Chen, W. +10 more
core +2 more sources
Genetically encoded indicators of neuronal activity [PDF]
Nature Neuroscience, 2016 Experimental efforts to understand how the brain represents, stores and processes information require high-fidelity recordings of multiple different forms of neural activity within functional circuits. Thus, creating improved technologies for large-scale recordings of neural activity in the live brain is a crucial goal in neuroscience.
Michael Z, Lin, Mark J, Schnitzer
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Gene-Drug Interaction in Stroke
Stroke Research and Treatment, 2011 Stroke is the third cause of mortality and one of most frequent causes of long-term neurological disability, as well as a complex disease that results from the interaction of environmental and genetic factors.
Serena Amici +3 more
doaj +1 more source
PLoS Genetics, 2014 Mitogen-activated protein kinase (MAPK) pathways are crucial signaling instruments in eukaryotes. Most ascomycetes possess three MAPK modules that are involved in key developmental processes like sexual propagation or pathogenesis.
I. Teichert +6 more
semanticscholar +1 more source