Results 181 to 190 of about 262,207 (307)

Amplification-Free Detection of Highly Structured RNA Molecules Using SCas12aV2. [PDF]

Bio Protoc
Hu T, Pei Y, Hu Z, Feng J, Jiang Q, Hu L, Liu Y.   +6 more
europepmc   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

TIGRa: An ultra-compact programmable activator enabling multiplexed and efficient gene regulation. [PDF]

Cell Stem Cell
Liu Z, Chen S, Wang W, Zhang F, Wang Q, Walkiewicz G, Hossen F, Zhou J, Wang Y, Sun Y.   +9 more
europepmc   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

From structural insight to molecule: Integrative molecular simulations identify candidate pyruvate kinase activators. [PDF]

PLoS One
Dermawan D, Alotaiq N.
europepmc   +1 more source

Detecting Activities

Journal of Visual Communication and Image Representation, 1994
Ramprasad Polana, Randal C. Nelson
openaire   +3 more sources

Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology

Molecular Oncology, EarlyView.
This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic, Maria Concetta Vitale, Rita Siino, Emilia Di Giovanni, Carla Ferrante Bannera, Enrico Di Marco, Andrea Gottardo, Tancredi Didier Bazan Russo, Nadia Barraco, Alessandro Perez, Valerio Gristina, Antonio Galvano, Giuseppe Badalamenti, Antonio Russo, Viviana Bazan, Lorena Incorvaia   +15 more
wiley   +1 more source

K_V7 channel activation inhibits human and murine myometrium contractility and delays delivery in a mouse model of preterm birth. [PDF]

Commun Med (Lond)
Mansour YT, Mistry HD, Chin-Smith EC, Zaleska MK, Sekulich DC, Herington JL, Reese J, Patel R, Aaronson PI, Slater DM, England SK, Greenwood IA, Johnson MR, Taylor PD, Tribe RM.   +14 more
europepmc   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Stoichiometric balance and sustained rhythms. [PDF]

J Math Biol
Chen KW, Shih CW.
europepmc   +1 more source