Results 241 to 250 of about 262,207 (307)

Inhibition of smooth muscle phenotypic modulation by bardoxolone methyl, omaveloxolone, and cinnamaldehyde is Nrf-2 dependent. [PDF]

Adv Redox Res
Babaki D, Buglak NE, Musetti B, Leon-Mateo Y, Xi G, Bahnson EM.   +5 more
europepmc   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Regulatory network topology and the genetic architecture of gene expression. [PDF]

Cell Genom
Aguirre M, Spence JP, Sella G, Pritchard JK.   +3 more
europepmc   +1 more source

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

FEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee, Giulia Zanetti, Bram van den Broek, Kees Jalink   +3 more
wiley   +1 more source

Ampyrone is a direct agonist of human tyrosinase and a potential therapeutic for hypopigmentation disorders. [PDF]

JCI Insight
Dolinska MB, Wang Y, Coussens NP, Kalaskar VK, Eraslan Z, Grondin SJ, Bonica J, Toay S, Hall MD, Shen M, Boxer M, Chen Q, Gross SS, Attarwala N, Jittayasothorn Y, Alur RP, Shukla D, Kee R, DeYoung C, Sha C, Adams DR, Loftus SK, Cogliati T, Sergeev YV, Zippin JH, Brooks BP.   +25 more
europepmc   +1 more source

Refinement of amino‐acid conformation vs. difference density maps in time‐resolved serial femtosecond crystallography data analysis

FEBS Open Bio, EarlyView.
The dFoCC pipeline starts with observed DED and resting‐state coordinates, which are then used to generate a library of triggered states. Correlation analysis of the calculated DED features of each candidate vs observed DED permits quantitative evaluation of candidate structural quality.
Meng Iao Fong, Yuhei Hosokawa, Lars Oliver Essen, Manuel Maestre‐Reyna   +3 more
wiley   +1 more source

Effect of a Composite Activator on Comprehensive Performance of Alkali-Activated Foam Concrete. [PDF]

Materials (Basel)
Hu Z, Xiong Y, Cai Y, Zheng S, Lv Y, Li Y, Zhao X, Wang Y, Ma L.   +8 more
europepmc   +1 more source

Lipopolysaccharide uptake is augmented in lipopolysaccharide‐tolerant mouse macrophage‐like cells via increased CD14 expression

FEBS Open Bio, EarlyView.
In normal (nontolerant) cells, CD14 is crucial for both LPS uptake and LPS signaling. In LPS‐tolerant cells, in which LPS‐induced TNF‐α and IFN‐β production is suppressed, there is a dramatic increase in surface CD14 expression. The overexpressed CD14 in LPS‐tolerant cells is responsible for the enhanced LPS uptake without inducing pro‐inflammatory ...
Saeka Nishihara, Takayuki Manabe, Mika Jouta, Kiyoshi Kawasaki   +3 more
wiley   +1 more source

Lipid-based nanocarriers for antifungal drug delivery. [PDF]

Discov Nano
Staniszewska A, Kala D, Kuryk Ł, Borkowska A, Kumar S, Staniszewska M.   +5 more
europepmc   +1 more source