Results 81 to 90 of about 262,207 (307)

Growth Augmentation with Activators [PDF]

, 1976
This research was performed to determine if bony changes could be effected by activator treatment and how stable this treatment is. From a sample of twenty-seven cases with before activator treatment cephalometric radiographs. Rocky Mountain Data Systems
Sibley, John R.
core   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Assessment of the performance of alkali-activated slag/fly ash using liquid and solid activators: early-age properties and efflorescence

The use of solid activators to prepare alkali-activated materials (AAM) holds great potential for on-site applications, as it eliminates the need to transport and store large quantities of concentrated alkaline solutions.
Gong, Jihao, Cao, Yubin, Ma, Yuwei, Wang, Yanru, Fu, Jiyang, Wang, Hao   +5 more
core   +1 more source

The LKB1-salt-inducible kinase pathway functions as a key gluconeogenic suppressor in the liver [PDF]

, 2014
LKB1 is a master kinase that regulates metabolism and growth through adenosine monophosphate-activated protein kinase (AMPK) and 12 other closely related kinases. Liver-specific ablation of LKB1 causes increased glucose production in hepatocytes in vitro
Gray, NS, Kaestner, Klaus H., Gray, Nathanael, Birnbaum, Morris J., Campbell, David G, Kaestner, KH, Wan, Min, Sakamoto, Kei, Gray, Nathanael S., Gray, Nathanael S, Göransson, Olga, Sutherland, C, Gourlay, R, Titchenell, Paul, Sutherland, Calum, Patel, Kashyap, Marion, Allison, Viollet, B, Foretz, Marc, Titchenell, P, Sutherland, Calum; id_orcid, Göransson, Olga,, Birnbaum, Morris J, Campbell, David G., Patel, K, Foretz, M, Deak, M, Gourlay, Robert, Göransson, O, Deak, Maria, Viollet, Benoit, Marion, A, Wan, M, Birnbaum, MJ, Tournier, Emilie, Campbell, DG, Peggie, Mark, Boudaba, Nadia, Kaestner, Klaus H, Sakamoto, K, Tournier, E, Peggie, M, Lund University., Boudaba, N   +43 more
core   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Active Matter [PDF]

The European Physical Journal E, 2013
The study of systems with sustained energy uptake and dissipation at the scale of the constituent particles is an area of central interest in nonequilibrium statistical physics. Identifying such systems as a distinct category -- Active Matter -- unifies our understanding of autonomous collective move- ment in the living world and in some surprising ...
Golestanian, R. ; https://orcid.org/0000-0002-3149-4002, Ramaswamy, S.   +1 more
openaire   +5 more sources

Predicted repetitive upstream activators.

, 2018
Depicted are upstream activators with an activation or inhibition Z score of respectively > 2.0 or < (-2.0) present in at least 2 time window comparisons. Positive Z-scores are depicted in green, negative Z-scores are depicted in blue.
Joris A. van der Post (5775086), Gijs Afink (535618), Carrie Ris-Stalpers (433356), Souad Boussata (5775083), Aldo Jongejan (793996), Febilla Fernando (3501119)   +5 more
core   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Pharmacological Investigation of a Novel Resveratrol-like SIRT1 Activator Endowed with a Cardioprotective Profile

Molecules
Sirtuin 1 (SIRT1) is an NAD+-dependent deacetylase implicated in various physiological and pathological processes, including cardiovascular diseases. The lead compound for SIRT1, resveratrol (1), as well as natural-derived and synthetic SIRT1-activating ...
Leonardo Carbonetti, Simone Brogi, Rosarita D’Orsi, Marco Lessi, Vincenzo Calderone, Lara Testai, Fabio Bellina   +6 more
doaj   +1 more source