Results 81 to 90 of about 750,135 (261)

Usage of Mobile X-Rays in Active Case-Finding for Tuberculosis

Journal of Innovation and Community Engagement
Indonesia has the world’s second-highest number of tuberculosis cases. More than 300,000 cases of tuberculosis in Indonesia have not been diagnosed or recorded, which are known as the missing cases. Undiagnosed tuberculosis patients will cause the spread
Cindra Paskaria, Elizabeth Wianto, Hapnes Toba   +2 more
doaj   +1 more source

Active tuberculosis case finding and detection of drug resistance among HIV-infected patients: A cross-sectional study in a TB endemic area, Gondar, Northwest Ethiopia

International Journal of Mycobacteriology, 2014
Background: Tuberculosis (TB) patients co-infected with human immunodeficiency virus (HIV) often lack the classic symptoms of pulmonary tuberculosis, making the diagnosis difficult. Current practices in resource-limited settings often indicate that these
Martha Alemayehu, Baye Gelaw, Ebba Abate, Liya Wassie, Yeshambel Belyhun, Shiferaw Bekele, Russell R Kempker, Henry M Blumberg, Abraham Aseffa   +8 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

FEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source

Improving active case finding for tuberculosis in South Africa: informing innovative implementation approaches in the context of the Kharitode trial through formative research

Health Research Policy and Systems, 2017
Background Tuberculosis (TB) is the leading infectious killer worldwide, with approximately 1.8 million deaths in 2015. While effective treatment exists, implementation of active case finding (ACF) methods to identify persons with active TB in a timely ...
Deanna Kerrigan, Nora West, Carrie Tudor, Colleen F. Hanrahan, Limakatso Lebina, Reginah Msandiwa, Lesego Mmolawa, Neil Martinson, David Dowdy   +8 more
doaj   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

A public–private partnership to reduce tuberculosis burden in Akwa Ibom State, Nigeria

International Journal of Mycobacteriology, 2015
Background: Tuberculosis (TB) infection and spread are preventable, and TB disease is curable depending on individual and community knowledge of causes of the disease, mode of prevention and cure.
Anne E Asuquo, Benjamin D. Thumamo Pokam, Emmanuel Ibeneme, Esu Ekpereonne, Valerie Obot, P N Asuquo   +5 more
doaj   +1 more source

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

Active Case Finding for Tuberculosis in the Community

, 2018
Tuberculosis (TB) remains a major global health problem. The World Health Organization (WHO) has set ambitious targets to eliminate TB by 2035. To achieve this, dramatic reductions in TB incidence must be achieved worldwide. Strategies to achieve these targets include the early detection and treatment of all patients with TB, and preventative treatment
openaire   +2 more sources