Results 91 to 100 of about 71,774 (244)
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Efficacy Evaluation of Ultrasound with Active Contour Model for Hemodialysis in Children with Renal Failure. [PDF]
Comput Math Methods Med, 2022 Huo J +5 more
europepmc +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Entropy and Gaussian Filter-Based Adaptive Active Contour for Segmentation of Skin Lesions. [PDF]
Comput Intell Neurosci, 2022 Mustafa S +6 more
europepmc +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
2-D delineation of individual citrus trees from UAV-based dense photogrammetric surface models
International Journal of Digital Earth, 2018 One of the challenges of remote sensing and computer vision lies in the three-dimensional (3-D) reconstruction of individual trees by using automated methods through very high-resolution (VHR) data sets.
Ali Ozgun Ok, Asli Ozdarici-Ok
doaj +1 more source
Segmentation of CT Lung Images Using FCM with Active Contour and CNN Classifier. [PDF]
Asian Pac J Cancer Prev, 2022 M M, P S, U M, K M, M N.
europepmc +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Narrow Band Active Contour Attention Model for Medical Segmentation. [PDF]
Diagnostics (Basel), 2021 Le N +4 more
europepmc +1 more source
Molecular Oncology, EarlyView.A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath +13 more
wiley +1 more source