Results 121 to 130 of about 4,733,293 (337)

BMP antagonist CHRDL2 enhances the cancer stem‐cell phenotype and increases chemotherapy resistance in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Overexpression of CHRDL2 in colon cancer cells makes them more stem‐like and resistant to chemo‐ and radiotherapy. CHRDL2‐high cells have upregulation of the WNT pathway, genes involved in the DNA damage response (DDR) pathway and epithelial‐to‐mesenchymal transition (EMT). This leads to quicker repair of damaged DNA and more cell migration.
Eloise Clarkson, Annabelle Lewis
wiley   +1 more source

Absolute Dating of Fault-Gouge Material Using Isothermal Thermoluminescence: An Example from the Nojima Fault Zone, SW Japan

open access: yesGeosciences
Establishing the absolute age of palaeoearthquakes is of great significance for the assessment of the seismicity and seismic hazards of a region. As such, several different geochronological techniques to date earthquake-related material have been ...
Evangelos Tsakalos   +5 more
doaj   +1 more source

Simultaneous inhibition of TRIM24 and TRIM28 sensitises prostate cancer cells to antiandrogen therapy, decreasing VEGF signalling and angiogenesis

open access: yesMolecular Oncology, EarlyView.
TRIM24 and TRIM28 are androgen receptor (AR) coregulators which exhibit increased expression with cancer progression. Both TRIM24 and TRIM28 combine to influence the response of castrate‐resistant prostate cancer (CRPC) cells to AR inhibitors by mediating AR signalling, regulation of MYC and upregulating VEGF to promote angiogenesis. Castrate‐resistant
Damien A. Leach   +8 more
wiley   +1 more source

The basic characteristics of active faults in the region of Xigaze,Xizang and the assessment of potential earthquake disaster risks

open access: yes地震科学进展
China is one of the countries in the world with the most frequent occurrence of continental earthquakes and the greatest impacts of earthquake disasters. In particular, the Qinghai-Tibet Plateau is a region characterized by a wide spatial distribution of
Ting Huang   +4 more
doaj   +1 more source

EMT‐associated bias in the Parsortix® system observed with pancreatic cancer cell lines

open access: yesMolecular Oncology, EarlyView.
The Parsortix® system was tested for CTC enrichment using pancreatic cancer cell lines with different EMT phenotypes. Spike‐in experiments showed lower recovery of mesenchymal‐like cells. This was confirmed with an EMT‐inducible breast cancer cell line.
Nele Vandenbussche   +8 more
wiley   +1 more source

Seismogeodynamics of interaction area of the Baikal rift northeastern flank and Aldan-Stanovoy block

open access: yesЛитосфера, 2016
The article presents modern structural-tectonic plan and tectonic-dynamic model of the zone of interaction of the most seismicity active northeastern part of the Baikal rift zone (BRZ) and the adjoint system seismogenic structures of the Aldan-Stanovoy ...
L. P. Imaeva   +3 more
doaj  

A DIA‐MS‐based proteomics approach to find potential serum prognostic biomarkers in glioblastoma patients

open access: yesMolecular Oncology, EarlyView.
A DIA‐MS‐based proteomics analysis of serum samples from GB patients and healthy controls showed that high levels of IL1R2 and low levels of CRTAC1 and HRG in serum are associated with poor survival outcomes for GB patients. These circulating proteins could serve as biomarkers for the prediction of outcome in patients with GB.
Anne Clavreul   +11 more
wiley   +1 more source

DC fault current clearance coordinated control strategy for DC grid with hybrid MMC

open access: yesInternational Journal of Electrical Power & Energy Systems
For DC grid based on the hybrid modular multilevel converter (MMC), the traditional DC fault current clearance scheme takes a long time and greatly affects the active power transmission.
Shouqi Jiang   +4 more
doaj  

Home - About - Disclaimer - Privacy