The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
Nonlinear Predictive Motion Control for Autonomous Mobile Robots Considering Active Fault-Tolerant Control and Regenerative Braking. [PDF]
Sensors (Basel), 2022 Hang P, Lou B, Lv C.
europepmc +1 more source
Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer
Molecular Oncology, EarlyView.PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta +10 more
wiley +1 more source
Design of Active Fault-Tolerant Control System for Air-Fuel Ratio control of Internal Combustion engine using nonlinear regression-based observer model. [PDF]
PLoS One, 2022 Alsuwian T +5 more
europepmc +1 more source
Molecular Oncology, EarlyView.To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley +1 more source
地震科学进展The eastern margin of the Tibetan Plateau is a tectonic transformation belt regulating the eastward extrusion of materials from the plateau. This area not only has high density active faults and high frequency strong earthquakes, but also has very ...
Zhonghai Wu +4 more
doaj +1 more source
Active Fault Localization of Actuators on Torpedo-Shaped Autonomous Underwater Vehicles. [PDF]
Sensors (Basel), 2021 Liu F +5 more
europepmc +1 more source
Timing of initiation of reverse displacement on the Taranaki Fault, northern Taranaki Basin: Constraints from the on land record (Oligocene Te Kuiti Group) [PDF]
, 2008 Structures associated with the wedge of basement overthrust into Taranaki Basin along the Taranaki Fault, are regarded as hydrocarbon plays and have been tested by drilling through the tip of the overthrust.
Kamp, Peter J.J. +1 more
core
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
Design of active fault-tolerant control system for Air-fuel ratio control of internal combustion engines using fuzzy logic controller. [PDF]
Sci Prog, 2022 Riaz U, Amin AA, Tayyeb M.
europepmc +1 more source