Results 41 to 50 of about 7,509 (291)
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Use of an NSGA-II Genetic Algorithm and Active Gate Driving to Improve Simulated GaN Power Electronic Switching Waveforms [PDF]
, 2022 This paper investigates the use of Evolutionary Multi-objective Optimization (EMO) algorithms to automatically optimise active gate driver patterns for hard-switched GaN bridge-legs.
Jahdi, Saeed +3 more
core +1 more source
CMOS Active Gate Driver for Closed-Loop d v /d t Control of GaN Transistors
, 2020 International audienceThis paper shows both theoretical and experimental analyses of a fully integrated CMOS active gate driver (AGD) developed to control the high dv/dt of GaN transistors for both 48 V and 400 V applications.
Cougo, Bernardo +4 more
core +2 more sources
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Micromachines, 2023 In this work, we demonstrated the thermal analysis of different flip-chip bonding designs for high power GaN HEMT developed for power electronics applications, such as power converters or photonic driver applications, with large gate periphery and chip ...
Kuo-Bin Hong +7 more
doaj +1 more source
GaN HEMT Gate Driver Circuit Utilizing Variable Capacitors [PDF]
Active gate drivers promise lowered switching energies, decreased over-voltages, and improved system EMI. Controllability of gate charging process in available active drivers is limited by discrete, multi-step changes in voltage and gate resistance, or ...
Beczkowski, Szymon; id_orcid +4 more
core +1 more source
Sequence Prediction for SiC MOSFET Active Gate Driving With a Recurrent Neural Network
IEEE Open Journal of Industry Applications, 2023 This article develops a recurrent neural network (RNN) with an encoder–decoder structure to predict the driving sequence of SiC MOSFET active gate drivers (AGDs).
Li Yang +3 more
doaj +1 more source
Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source
Building blocks for future dual-channel GaN gate drivers Arbitrary waveform driver, bootstrap voltage supply, and level shifter [PDF]
, 2019 Capitalising on the high-speed switching capability of 650 V GaN FETs in power-electronic bridgelegs is challenging. Whilst active gate driving has previously been shown to help overcome adverse switching behaviour, the best results are likely to be ...
Liu, Dawei +3 more
core +2 more sources
Status and Trend of IGBT Gate Drive Technology
Kongzhi Yu Xinxi Jishu, 2015 In this paper, the new requirements to gate drivers caused by IGBT were analysed as well as the IGBT operating characteristics. Moreover, through the analysis of typical products from the vendors of the mainstream gate driver, the status and the trend of
JIAO Mingliang +4 more
doaj