Results 91 to 100 of about 2,358,768 (289)

Preconditioning of Active-Set Newton Methods for PDE-constrained Optimal Control Problems

, 2015
We address the problem of preconditioning a sequence of saddle point linear systems arising in the solution of PDE-constrained optimal control problems via active-set Newton methods, with control and (regularized) state constraints.
Porcelli, Margherita, Simoncini, Valeria, Tani, Mattia   +2 more
core   +1 more source

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Mueller-matrix ellipsometry studies of optically active structures in scarab beetles

EPJ Web of Conferences, 2010
The complexity of multilayers, photonic crystals, metamaterials and other artificial materials has promoted the use of spectroscopic, variable angle, generalized and Mueller-matrix ellipsometry.
Arwin H., Landin J., Järrendahl K.
doaj   +1 more source

Matrix Metalloproteinases Activities in Hypertension [PDF]

Hypertension, 2011
See related article, pp 123–130 One of the challenges in the development of molecular models of hypertension as a disease with end organ failure is the multifaceted nature of complications that accompany elevated blood pressure. Comorbidities can be detected even at early stages of hypertension and in patients with family history of hypertension even ...
openaire   +1 more source

Automated Selection of Active Orbital Spaces

, 2016
One of the key challenges of quantum-chemical multi-configuration methods is the necessity to manually select orbitals for the active space. This selection requires both expertise and experience and can therefore impose severe limitations on the ...
Reiher, Markus, Stein, Christopher J.
core   +2 more sources

Cotargeting TREM2 and IL2 pathways triggers multipronged anticancer immunity

Molecular Oncology, EarlyView.
Von Locquenghien et al. report that MiTE‐144, a triggering receptor expressed on myeloid cells 2 (TREM2) blocking antibody fused to interleukin‐2 (IL2) variant with tumour microenvironment restricted activation, demonstrates superior anticancer efficiency in a preclinical setting.
Isaure Vanmeerbeek, Jenny Sprooten, Abhishek D. Garg   +2 more
wiley   +1 more source

Integrated photonic programmable random matrix generator with minimal active components

npj Nanophotonics
Random matrices are fundamental in photonic computing because of their ability to model and enhance complex light interactions and signal processing capabilities.
Kevin Zelaya, Mostafa Honari-Latifpour, Mohammad-Ali Miri   +2 more
doaj   +1 more source

Matrix Factorization With Rating Completion: An Enhanced SVD Model for Collaborative Filtering Recommender Systems

IEEE Access, 2017
Collaborative filtering algorithms, such as matrix factorization techniques, are recently gaining momentum due to their promising performance on recommender systems. However, most collaborative filtering algorithms suffer from data sparsity.
Xin Guan, Chang-Tsun Li, Yu Guan
doaj   +1 more source

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source