Results 151 to 160 of about 3,741,697 (242)

Exploring the Role of Anti-solvent Effects during Washing on Active Pharmaceutical Ingredient Purity. [PDF]

Org Process Res Dev, 2021
Shahid M, Sanxaridou G, Ottoboni S, Lue L, Price C.   +4 more
europepmc   +1 more source

An Integrated Oxygen‐Supplying Device and Predictive Multiphysics Model for Extended Ambient Transport of Insulin‐Producing Cells

Advanced Functional Materials, EarlyView.
Cell therapies typically rely on cold‐chain logistics and cryopreservation, limiting access and compromising cell quality. Here, a dual‐chamber device separates an oxygen‐supplying chamber from a hyaluronic acid cargo chamber, sustaining oxygen delivery for over 70 h and enabling ambient‐temperature shipment.
Daniel A. Domingo‐Lopez, Ruth Tarpey, Benjamin Brennan, Bryan D. Boyle, Amir M. Alsharabasy, Abhik Mallick, Gabriella Bellavia, Abhay Pandit, Garry P. Duffy, Ruth E. Levey   +9 more
wiley   +1 more source

CONTINUOUS-FLOW SYNTHESIS AND OPTIMIZATION OF ASPIRIN AS A MODEL ACTIVE PHARMACEUTICAL INGREDIENT: PROCESS EVALUATION AND COMPARATIVE PHARMACEUTICAL RELEVANCE

Continuous-flow chemistry is an important process-intensification approach for active pharmaceutical ingredient synthesis because it provides precise control over residence time, temperature, pressure, mixing, and reagent delivery.
Reena Rathore
core   +1 more source

Economic evidence of alternative formulations and routes of administration for identical active pharmaceutical ingredient: a systematic review. [PDF]

Health Econ Rev
Shao H, Jiang Y, Zhao M, Tang W.
europepmc   +1 more source

Myogenic Fusogen‐Engineered Lipid Nanoparticles Enhance mRNA Delivery in Skeletal Muscle

Advanced Functional Materials, EarlyView.
This study reports a biomimetic strategy of engineering full‐length Myomaker, a muscle‐specific fusogen, into lipid nanoparticles (LNPs) to harness the native myoblast fusion capability for skeletal muscle mRNA delivery. The resulting Mymk‐LNPs enhance transfection in differentiating myocytes and enable Cre‐mediated reporter activation in injured ...
Fangyu Zhang, Zhisheng Xu, Yaou Duan, Yehui Sun, Shiying Wu, Tao Long, Mateusz Durbacz, Li Zhang, Yufen Xiao, Yu‐Chung Pien, Erick D. Guerrero, Zeru Tian, Xu Wang, Pratima Basak, Sumanta Chatterjee, Ning Liu, Xiaochun Li, Eric N. Olson, Daniel J. Siegwart   +18 more
wiley   +1 more source

Kinetics of active pharmaceutical ingredient solubility in water with different hydrogen isotopic content

Kinetic analysis by means of low-angle laser light scattering has been used for the investigation into active pharmaceutical ingredients solubility depending on the content of heavy isotope of hydrogen1 2H (D) in water.
Anfimova E.V., Pleteneva T.V., Syroeshkin A.V., Uspenskaya E.V.   +3 more
core  

Solubility of Incongruently Melting Active Pharmaceutical Ingredient Cocrystals: The Hydrochlorothiazide-Nicotinamide System. [PDF]

Mol Pharm
Nasrallah S, Gavali T, Yavuz I, Minceva M.   +3 more
europepmc   +1 more source

Self‐Assembled Hybrid Cell‐Enzyme Materials for Gas‐Powered Biocatalysis

Advanced Functional Materials, EarlyView.
Integrating living cells with programmable enzyme networks enables hybrid materials that convert gaseous feedstocks into chemical reducing power. These gas‐powered catalytic beads operate as modular, recyclable platforms for adaptive biocatalysis and sustainable synthesis.
Marius Stoeckle, Kersten S. Rabe, Christof M. Niemeyer   +2 more
wiley   +1 more source

Acute and Chronic Toxicity of Ketoprofen Active Pharmaceutical Ingredient and Commercial Formulations to the Freshwater Photosynthetic Species <i>Microcystis novacekii</i> and <i>Chlorella vulgaris</i>. [PDF]

Int J Environ Res Public Health
Souza-Silva G, Silva MIGA, Miranda ACB, Alcântara MD, Souza CR, Silveira MR.   +5 more
europepmc   +1 more source

Analysis of complex drugs by comprehensive two-dimensional gas chromatography and high-resolution mass spectrometry: detailed chemical description of the active pharmaceutical ingredient sodium bituminosulfonate and its process intermediates. [PDF]

Anal Bioanal Chem, 2023
Schwalb L, Tiemann O, Käfer U, Gröger T, Rüger CP, Gayko G, Zimmermann R.   +6 more
europepmc   +1 more source