Results 201 to 210 of about 1,638,765 (242)

Revealing GRK5 Activation Features by Interpretable Machine Learning and Molecular Dynamics Simulation. [PDF]

Int J Mol Sci
Song Y, Kong M, Zhang F, Pu X.
europepmc   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Mapping the Structure and Conformational Landscape of the 10-23 DNAzyme. [PDF]

ACS Chem Biol
Cramer ER, Shultz HL, Purdy MD, Cooper DR, Robart AR.   +4 more
europepmc   +1 more source

The crystal structure of the Borrelia burgdorferi nicotinamidase BBE22 resolves a long‐standing annotation error

FEBS Open Bio, EarlyView.
The crystal structure of Borrelia burgdorferi nicotinamidase (PncA/BBE22) reveals the correct full‐length protein initiated from a non‐canonical AUU start codon. The structure validates previous biochemical findings and resolves a long‐standing annotation error, demonstrating that the truncated database sequence is structurally incompatible with the ...
Kalvis Brangulis
wiley   +1 more source

Scalable Bayesian Image-on-Scalar Regression for Population-Scale Neuroimaging Data Analysis. [PDF]

J Am Stat Assoc
Xu Y, Johnson TD, Nichols TE, Kang J.
europepmc   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Assessment of active and inactive sacroiliitis in axial spondyloarthritis using DCE-MRI and ZOOMit-DWI parameters: A prospective study. [PDF]

Medicine (Baltimore)
Zhu Q, Cao S, Wang Q, Hu X, Dang X, Liu M, Yu X.   +6 more
europepmc   +1 more source

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

Age-related differences in asymmetric synapses across the central inferior colliculus in the Fischer Brown Norway rat. [PDF]

Aging Brain
Barach GL, Wawrzyniak A, Busby J, Duncan S, Almassri LS, Mafi A, Tokar NJ, Silveira MA, Young JW, Mellott JG.   +9 more
europepmc   +1 more source

Reductions in malaria cases after deployment of dual-active ingredient insecticide-treated nets in Ghana-a Bayesian interrupted time series analysis. [PDF]

Int J Epidemiol
Oppong SK, Owusu-Akrofi O, Atta-Obeng C, Coleman S, Amratia P, Symons TL, Alene KA, Peprah NY, Gething PW, Malm KL.   +9 more
europepmc   +1 more source