Results 71 to 80 of about 8,578,817 (287)

Improvement of the Solubility, Permeability, and Pharmacological Activity of Decoquinate-Loaded Hydroxypropyl-β-Cyclodextrin–Tea Saponins Ternary ComplexA

open access: yesPharmaceuticals
Objectives: This study was performed to simultaneously improve the solubility, permeability, and pharmacological activity of decoquinate (DQ). Methods: A ternary DQ solid dispersion with hydroxypropyl-β-cyclodextrin (HP-β-CD) and tea saponin (TS) was ...
Wei Wei, Qihong Zhang, Weike Su
doaj   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

open access: yesFEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi   +6 more
wiley   +1 more source

Influence of education and socio-economic status on physical activity of adult residents of regions Eastern Bohemia and Vysocina between 2005-2009

open access: yesTělesná Kultura, 2011
BACKGROUND: Physical activity (PA) promotion is one of the most important factors in prevention of non-infectious civilization diseases. Other factors that may affect PA (economical, environmental, socio-cultural, etc.) are intensively monitored in ...
Dana Feltlová   +5 more
doaj   +1 more source

Transportation Development Division, Active Transportation Section

open access: yes, 2015
This archived document is maintained by the Oregon State Library as part of the Oregon Documents Depository Program. It is for informational purposes and may not be suitable for legal purposes.Title from PDF caption (viewed on March 9, 2015).Mode of ...

core  

Investigating transcription factor dynamics in health and disease using FRAP

open access: yesFEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj   +3 more
wiley   +1 more source

"Happy thought", Prosp. [i.e. prospecting] party, A.C. (?) Black, leader, C.H. Stiles, R.W. Johnston, R.A. Boyd, 1894 [picture] /

open access: yes, 1894
Title from caption.; Caption note: Initials of Black, the leader of the prospecting team unclear, possibly A.C.; Part of collection: Photographs.; Exhibited: "Travellers Art", National Library of Australia, 12 June 2003-21 September 2003; Exhibited ...
Millar, Roy, active 1884-1900.
core  

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

open access: yesFEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang   +4 more
wiley   +1 more source

Asteroseismic Signature of a Large Active Region

open access: yesFrontiers in Astronomy and Space Sciences, 2019
Axisymmetric magnetic activity on the Sun and sun-like stars increases the frequencies of the modes of acoustic oscillation. However, it is unclear how a corotating patch of activity affects the oscillations, since such a perturbation is unsteady in the ...
Emanuele Papini   +2 more
doaj   +1 more source

Transportation Development Division, Active Transportation Section [PDF]

open access: yes
This archived document is maintained by the Oregon State Library as part of the Oregon Documents Depository Program. It is for informational purposes and may not be suitable for legal purposes.Title from PDF caption (viewed on April 11, 2014)Mode of ...

core  

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

open access: yesFEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta   +3 more
wiley   +1 more source

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