Results 71 to 80 of about 1,638,765 (242)

Improvement of the Solubility, Permeability, and Pharmacological Activity of Decoquinate-Loaded Hydroxypropyl-β-Cyclodextrin–Tea Saponins Ternary ComplexA

Pharmaceuticals
Objectives: This study was performed to simultaneously improve the solubility, permeability, and pharmacological activity of decoquinate (DQ). Methods: A ternary DQ solid dispersion with hydroxypropyl-β-cyclodextrin (HP-β-CD) and tea saponin (TS) was ...
Wei Wei, Qihong Zhang, Weike Su
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Influence of education and socio-economic status on physical activity of adult residents of regions Eastern Bohemia and Vysocina between 2005-2009

Tělesná Kultura, 2011
BACKGROUND: Physical activity (PA) promotion is one of the most important factors in prevention of non-infectious civilization diseases. Other factors that may affect PA (economical, environmental, socio-cultural, etc.) are intensively monitored in ...
Dana Feltlová, Josef Mitáš, Lucie Kubíčková, Karel Frömel, Pavel Šmíd, Jan Dygrýn   +5 more
doaj   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Phosphorus diffusion using a solid planar source in integrated circuit manufacturing

Технологія та конструювання в електронній апаратурі, 2008
The results of the development and implementation of a basic phosphorus diffusion process for the formation of the active region of a power silicon transistor are presented.
B. A. Shangereeva
doaj  

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Asteroseismic Signature of a Large Active Region

Frontiers in Astronomy and Space Sciences, 2019
Axisymmetric magnetic activity on the Sun and sun-like stars increases the frequencies of the modes of acoustic oscillation. However, it is unclear how a corotating patch of activity affects the oscillations, since such a perturbation is unsteady in the ...
Emanuele Papini, Laurent Gizon, Laurent Gizon   +2 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Solar active region magnetogram image dataset for studies of space weather. [PDF]

Sci Data, 2023
Boucheron LE, Vincent T, Grajeda JA, Wuest E.   +3 more
europepmc   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source