Results 261 to 270 of about 11,841,496 (406)

Aberrant expression of nuclear prothymosin α contributes to epithelial‐mesenchymal transition in lung cancer

Molecular Oncology, EarlyView.
Nuclear prothymosin α inhibits epithelial‐mesenchymal transition (EMT) in lung cancer by increasing Smad7 acetylation and competing with Smad2 for binding to SNAI1, TWIST1, and ZEB1 promoters. In early‐stage cancer, ProT suppresses TGF‐β‐induced EMT, while its loss in the nucleus in late‐stage cancer leads to enhanced EMT and poor prognosis.
Liyun Chen, Chung‐Teng Wang, Jia‐Ming Chang, Ai‐Li Shiau, Gia‐Shing Shieh, Yau‐Lin Tseng, Yi‐Ting Yen, Tang‐Hsiu Huang, Li‐Hsin Cheng, Yu‐Chih Wu, Chao‐Liang Wu, Bing‐Hua Su, Pensee Wu   +12 more
wiley   +1 more source

RNase W, a conserved ribonuclease family with a novel active site. [PDF]

Nucleic Acids Res
Vayssières M, Jüttner M, Haas K, Ancelin A, Marchfelder A, Leulliot N, Ferreira-Cerca S, Blaud M.   +7 more
europepmc   +1 more source

Probing the topography of the active site of alpha-chymotrypsin.

, 1967
Bernard F. Erlanger
openalex   +1 more source

The mechanism of action of superoxide dismutase from pulse radiolysis and electron paramagnetic resonance. Evidence that only half the active sites function in catalysis [PDF]

, 1974
E.M. Fielden, Peter Roberts, Robert C. Bray, David J. Lowe, Gillian N. Mautner, Giuseppe Rotilio, Lilia Calabrese   +6 more
openalex   +1 more source

Early metastasis is characterized by Gr1+ cell dysregulation and is inhibited by immunomodulatory nanoparticles

Molecular Oncology, EarlyView.
Breast cancer metastasis is associated with myeloid cell dysregulation and the lung‐specific accumulation of tumor‐supportive Gr1+ cells. Gr1+ cells support metastasis, in part, through a CHI3L1‐mediated mechanism, which can be targeted and inhibited with cargo‐free, polymeric nanoparticles.
Jeffrey A. Ma, Sophia M. Orbach, Kate V. Griffin, Kathryn Kang, Yining Zhang, Rebecca S. Pereles, Ian A. Schrack, Guillermo Escalona, Jacqueline S. Jeruss, Lonnie D. Shea   +9 more
wiley   +1 more source

Coupling between the lever arm and active site via an N-terminal extension tunes force sensitivity in the myosin-1 family. [PDF]

Proc Natl Acad Sci U S A
Rathbone HW, Houdusse A.
europepmc   +1 more source

Nonclassical Antimetabolites XVI. The Bridge Principle of Specificity with Active Site-Directed Irreversible Inhibitors, VII. Detection of Differences in Specificity of Enzymic Nucleophilic Sites by the Maleamyl Group

, 1963
B. R. Baker, Prabodh I. Alumaula
openalex   +1 more source

Beyond digital twins: the role of foundation models in enhancing the interpretability of multiomics modalities in precision medicine

FEBS Open Bio, EarlyView.
This review highlights how foundation models enhance predictive healthcare by integrating advanced digital twin modeling with multiomics and biomedical data. This approach supports disease management, risk assessment, and personalized medicine, with the goal of optimizing health outcomes through adaptive, interpretable digital simulations, accessible ...
Sakhaa Alsaedi, Xin Gao, Takashi Gojobori   +2 more
wiley   +1 more source

Spontaneous and chaperone-assisted metal loading in the active site of protein phosphatase-1. [PDF]

FEBS Lett
Van der Hoeven G, Lemaire S, Cao X, Claes Z, Karamanou S, Bollen M.   +5 more
europepmc   +1 more source

Mapping Hsp104 interactions using cross‐linking mass spectrometry

FEBS Open Bio, EarlyView.
This study examines how cross‐linking mass spectrometry can be utilized to analyze ATP‐induced conformational changes in Hsp104 and its interactions with substrates. We developed an analytical pipeline to distinguish between intra‐ and inter‐subunit contacts within the hexameric homo‐oligomer and discovered contacts between Hsp104 and a selected ...
Kinga Westphal, Karolina Michalska, Andrzej Joachimiak, Lukasz A. Joachimiak   +3 more
wiley   +1 more source