Results 21 to 30 of about 610,101 (198)

Nucleocytoplasmic transport: a thermodynamic mechanism [PDF]

arXiv, 2009
The nuclear pore supports molecular communication between cytoplasm and nucleus in eukaryotic cells. Selective transport of proteins is mediated by soluble receptors, whose regulation by the small GTPase Ran leads to cargo accumulation in, or depletion ...
Adam SA, Akey CW, Alber F, Bapteste E, Beck M, Becskei A, Ben‐Efraim I, Bickel T, Caspi Y, Catimel B, Cingolani G, Coppey M, Costa M, Cronshaw JM, Dange T, Denning DP, Devos D, Dixon M, Fanara P, Fradin C, Fradin C, Frey S, Grünwald D, Görlich D, Haldane JBS, Harreman MT, Henderson GP, Hinshaw JE, Hodel AE, Hu W, Hübner S, Jovanovic‐Talisman T, Kalab P, Kalderon D, Kapon R, Kobe B, Kopito RB, Kose S, Kotera I, Kubitscheck U, Kustanovich T, Köhler M, Lam MH, Lee SJ, Lyman SK, Mans BJ, Melcák I, Michael Elbaum, Michael WM, Miyamoto Y, Nachury MV, Naim B, Nakielny S, Newmeyer DD, Ossareh‐Nazari B, Pederson T, Pollard VW, Pyhtila B, Ribbeck K, Ribbeck K, Riddick G, Riddick G, Rihs HP, Robbins J, Ronen Benjamine Kopito, Rout MP, Salman H, Schmidt‐Zachmann MS, Schwartz TU, Shah S, Smith A, Stade K, Steggerda SM, Stein WD, Stoffler D, Strawn LA, Timney BL, Tokunaga M, Wen W, Yang Q, Yang W, Yang W, Zeitler B, Zilman A   +83 more
core   +3 more sources

Murine leukemia virus infection of non-dividing dendritic cells is dependent on nucleoporins.

PLoS Pathogens
Retroviral reverse transcription starts within the capsid and uncoating and reverse transcription are mutually dependent. There is still debate regarding the timing and cellular location of HIV's uncoating and reverse transcription and whether it occurs ...
Karen Salas-Briceno, Wenming Zhao, Susan R Ross   +2 more
doaj   +2 more sources

Nuclear actin structure regulates chromatin accessibility

Nature Communications
Polymerized β-actin may provide a structural basis for chromatin accessibility and actin transport into the nucleus can guide mesenchymal stem cell (MSC) differentiation.
Buer Sen, Zhihui Xie, Michelle D. Thomas, Samantha G. Pattenden, Sean Howard, Cody McGrath, Maya Styner, Gunes Uzer, Terrence S. Furey, Janet Rubin   +9 more
doaj   +2 more sources

Balance of osmotic pressures determines the volume of the cell nucleus

bioRxiv, 2021
The volume of the cell nucleus varies across cell-types and species, and is commonly thought to be determined by the size of the genome and degree of chromatin compaction.
Dan Deviri, S. Safran
semanticscholar   +1 more source

Active Nuclear Import of Mammalian Cell-Expressible DNA Origami

Journal of the American Chemical Society, 2023
DNA origami enables the creation of complex 3D shapes from genetic material. Future uses could include the delivery of genetic instructions to cells, but nuclear import remains a major barrier to gene delivery due to the impermeability of the nuclear ...
Anna Liedl, J. Griessing, J. Kretzmann, Hendrik Dietz   +3 more
semanticscholar   +1 more source

A conserved role for the ESCRT membrane budding complex in LINE retrotransposition. [PDF]

PLoS Genetics, 2017
Long interspersed nuclear element-1s (LINE-1s, or L1s) are an active family of retrotransposable elements that continue to mutate mammalian genomes.
Axel V Horn, Ivana Celic, Chun Dong, Irena Martirosyan, Jeffrey S Han   +4 more
doaj   +1 more source

Keratin Dynamics: Modeling the Interplay between Turnover and Transport [PDF]

, 2015
Keratin are among the most abundant proteins in epithelial cells. Functions of the keratin network in cells are shaped by their dynamical organization. Using a collection of experimentally-driven mathematical models, different hypotheses for the turnover
Chung, Andy, Leube, Rudolf E., Madzvamuse, Anotida, Portet, Stephanie, Windoffer, Reinhard   +4 more
core   +7 more sources

Ultrastructural identification of developing proximal tubules based on three‐dimensional reconstruction

Veterinary Medicine and Science, 2021
Background The cellular mechanisms involved in the development of proximal tubules are not only associated with morphogenesis in fetal life, but also with restoration of damaged tubules in adulthood.
Jing Cong, Shi‐Jie Chang, Jesper Skovhus Thomsen, Arne Andreasen, Xue Chen, Jia Xing, Jie Zhang, Ling Gu, Xiao‐Yue Zhai   +8 more
doaj   +1 more source

Quantitative Nucleocytoplasmic Transport Assays in Cellular Models of Neurodegeneration

Bio-Protocol, 2020
Nucleocytoplasmic transport deficits are suggested to play a role in neurodegenerative disorders, including amyotrophic lateral sclerosis (ALS). Given the importance and complexity of this process, understanding when these aberrations occur and which ...
Joni Vanneste, Thomas Vercruysse, Philip Van Damme, Ludo Van Den Bosch, Dirk Daelemans   +4 more
doaj   +1 more source

Fragile X–Related Protein 1 Regulates Nucleoporin Localization in a Cell Cycle–Dependent Manner

Frontiers in Cell and Developmental Biology, 2021
Nuclear pore complexes (NPCs) are embedded in the nuclear envelope (NE) where they ensure the transport of macromolecules between the nucleus and the cytoplasm.
Arantxa Agote-Arán, Arantxa Agote-Arán, Arantxa Agote-Arán, Arantxa Agote-Arán, Junyan Lin, Junyan Lin, Junyan Lin, Junyan Lin, Izabela Sumara, Izabela Sumara, Izabela Sumara, Izabela Sumara   +11 more
doaj   +1 more source