Results 21 to 30 of about 331,002 (265)
Axonal T3 uptake and transport can trigger thyroid hormone signaling in the brain
eLife, 2023 The development of the brain, as well as mood and cognitive functions, are affected by thyroid hormone (TH) signaling. Neurons are the critical cellular target for TH action, with T3 regulating the expression of important neuronal gene sets. However, the
Federico Salas-Lucia +7 more
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Mapping eGFP oligomer mobility in living cell nuclei. [PDF]
PLoS ONE, 2009 Movement of particles in cell nuclei can be affected by viscosity, directed flows, active transport, or the presence of obstacles such as the chromatin network.
Nicolas Dross +5 more
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The role of spatial averaging in the precision of gene expression patterns [PDF]
, 2009 During embryonic development, differentiating cells respond via gene expression to positional cues from morphogen gradients. While gene expression is often highly erratic, embryonic development is precise. We show by theory and simulations that diffusion
Erdmann, Thorsten +2 more
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Intracellular Localization of Blattella germanica Densovirus (BgDV1) Capsid Proteins
Viruses, 2018 Densovirus genome replication and capsid assembly take place in the nucleus of the infected cells. However, the mechanisms underlying such processes as the delivery of virus proteins to the nucleus and the export of progeny virus from the nucleus remain ...
Evgeny N. Kozlov +4 more
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Yeast karyopherin Kap95 is required for cell cycle progression at Start
BMC Cell Biology, 2010 Background The control of the subcellular localization of cell cycle regulators has emerged as a crucial mechanism in cell division regulation. The active transport of proteins between the nucleus and the cytoplasm is mediated by the transport receptors ...
Igual Juan, Taberner Francisco
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Novel Anthra[1,2-c][1,2,5]Thiadiazole-6,11-Diones as Promising Anticancer Lead Compounds: Biological Evaluation, Characterization & Molecular Targets Determination. [PDF]
PLoS ONE, 2016 The novel compounds NSC745885 and NSC757963 developed at our laboratory were tested against a panel of 60 cancer cell lines at the National Cancer Institute, USA, and a panel of 39 cancer cell lines at the Japanese Foundation of Cancer Research.
Ahmed Atef Ahmed Ali +7 more
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Nuclear Herpesvirus Capsid Motility Is Not Dependent on F-Actin
mBio, 2014 A considerable part of the herpesvirus life cycle takes place in the host nucleus. While much progress has been made to understand the molecular processes required for virus replication in the nucleus, much less is known about the temporal and spatial ...
Jens B. Bosse +7 more
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Defining the subcellular interface of nanoparticles by live-cell imaging. [PDF]
PLoS ONE, 2013 Understanding of nanoparticle-bio-interactions within living cells requires knowledge about the dynamic behavior of nanomaterials during their cellular uptake, intracellular traffic and mutual reactions with cell organelles. Here, we introduce a protocol
Peter H Hemmerich, Anna H von Mikecz
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Botanical Studies, 2019 Background Endosperm is a triploid tissue in seed resulting from a sperm nucleus fused with the binucleate central cell after double fertilization. Endosperm may be involved in metabolite production, solute transport, nutrient storage, and germination ...
Ming-Der Shih +4 more
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Nucleocytoplasmic shuttling activity of ataxin-3. [PDF]
PLoS ONE, 2009 Spinocerebellar ataxia type-3, also known as Machado-Joseph Disease (MJD), is one of many inherited neurodegenerative disorders caused by polyglutamine-encoding CAG repeat expansions in otherwise unrelated genes.
Sandra Macedo-Ribeiro +3 more
doaj +1 more source