Intracellular Localization of Blattella germanica Densovirus (BgDV1) Capsid Proteins
Densovirus genome replication and capsid assembly take place in the nucleus of the infected cells. However, the mechanisms underlying such processes as the delivery of virus proteins to the nucleus and the export of progeny virus from the nucleus remain ...
Evgeny N. Kozlov+4 more
doaj +1 more source
Mapping eGFP oligomer mobility in living cell nuclei. [PDF]
Movement of particles in cell nuclei can be affected by viscosity, directed flows, active transport, or the presence of obstacles such as the chromatin network.
Nicolas Dross+5 more
doaj +1 more source
Microtubule Defects Influence Kinesin-Based Transport In Vitro [PDF]
Microtubules are protein polymers that form "molecular highways" for long-range transport within living cells. Molecular motors actively step along microtubules to shuttle cellular materials between the nucleus and the cell periphery; this transport is critical for the survival and health of all eukaryotic cells.
arxiv +1 more source
Yeast karyopherin Kap95 is required for cell cycle progression at Start
Background The control of the subcellular localization of cell cycle regulators has emerged as a crucial mechanism in cell division regulation. The active transport of proteins between the nucleus and the cytoplasm is mediated by the transport receptors ...
Igual Juan, Taberner Francisco
doaj +1 more source
HER2-positive breast cancer (HER2+) occurs in approximately 15-20% of all breast cancers. Biologically this cancer subtype is characterized by an aggressive clinical course (often spread to regional lymph nodes at the time of diagnosis), and after ...
A. Kowalik+5 more
semanticscholar +1 more source
The F-actin filament capping protein CapG is a bona fide nucleolar protein [PDF]
Actin works in concert with myosin I to regulate the transcription of ribosomal genes in the nucleolus. Recently, nucleolar actin has been shown to be active in its polymeric form raising the question how actin dynamics is regulated in the nucleolus ...
Gettemans, Jan+3 more
core +2 more sources
Novel Anthra[1,2-c][1,2,5]Thiadiazole-6,11-Diones as Promising Anticancer Lead Compounds: Biological Evaluation, Characterization & Molecular Targets Determination. [PDF]
The novel compounds NSC745885 and NSC757963 developed at our laboratory were tested against a panel of 60 cancer cell lines at the National Cancer Institute, USA, and a panel of 39 cancer cell lines at the Japanese Foundation of Cancer Research.
Ahmed Atef Ahmed Ali+7 more
doaj +1 more source
Intracellular partitioning of cell organelles and extraneous nanoparticles during mitosis [PDF]
The nucleocytoplasmic partitioning of nanoparticles as a result of cell division is highly relevant to the field of nonviral gene delivery. We reviewed the literature on the intracellular distribution of cell organelles (the endosomal vesicles, Golgi ...
Braeckmans, Kevin+5 more
core +1 more source
Nuclear Herpesvirus Capsid Motility Is Not Dependent on F-Actin
A considerable part of the herpesvirus life cycle takes place in the host nucleus. While much progress has been made to understand the molecular processes required for virus replication in the nucleus, much less is known about the temporal and spatial ...
Jens B. Bosse+7 more
doaj +1 more source
Defining the subcellular interface of nanoparticles by live-cell imaging. [PDF]
Understanding of nanoparticle-bio-interactions within living cells requires knowledge about the dynamic behavior of nanomaterials during their cellular uptake, intracellular traffic and mutual reactions with cell organelles. Here, we introduce a protocol
Peter H Hemmerich, Anna H von Mikecz
doaj +1 more source