Results 121 to 130 of about 32,974 (249)

Microarray Analysis of PBMC after Plasmodium falciparum Infection: Molecular Insights into Disease Pathogenesis [PDF]

, 2011
Our laboratory’s previous microarray analysis of subjects with Plasmodium falciparum revealed up-regulation of Toll-like receptor, NF-kB, TNF-α, IFN-γ, IL-1β, p38 MAPK, and MHC molecules.
Alan Scott, Anne Jedlicka, August Louis Bourgeois, Nathan Wolfe, Sher Singh, Wan-Chung(Wan-Jiung) Hu   +5 more
core   +1 more source

Concurrence of the Core Mechanistic Tenets of the American Heart Association Statement on the Cardiovascular–Kidney–Metabolic Syndrome and the Adipokine Hypothesis of Heart Failure With Preserved Ejection Fraction

Diabetes, Obesity and Metabolism, EarlyView.
Milton Packer
wiley   +1 more source

Secretome and Pathway Analysis of Stress Induced Disc Degeneration In Vitro

JOR SPINE, Volume 9, Issue 2, June 2026.
Integrated secretome and phosphoprotein profiling of human nucleus pulposus cells revealed that IL‐1β and TLR2/6 activation induce a shared degenerative program, defined by consistent upregulation of IL‐6, IL‐8, GRO‐α, ICAM‐1, and MMP‐7 and convergence on NF‐κB/AP‐1 signaling.
Exarchos Kanelis, Andrea Nüesch, Joseph Snuggs, Christine Lyn Le Maitre, Leonidas G. Alexopoulos   +4 more
wiley   +1 more source

Characterization of the mechanism of inhibin α-subunit gene in mouse anterior pituitary cells by RNA interference.

PLoS ONE, 2013
Inhibin, a member of the transforming growth factor-β [TGF-β] superfamily, is a suppressor of follicle-stimulating hormone [FSH] release through pituitary-gonadal negative feedback loop to regulate follicular development. In this study, Inhibin α-subunit
Li Han, Canjie Wu, Hasan Riaz, Liya Bai, Jianguo Chen, Yanhong Zhen, Aizhen Guo, Liguo Yang   +7 more
doaj   +1 more source

PACAP induces FSHβ gene expression via EPAC. [PDF]

, 2019
Gonadotropins, luteinizing hormone (LH) and follicle-stimulating hormone (FSH), are heterodimers of a common α subunit and unique β subunits. Regulation of their levels, primarily by GnRH, is critical for reproductive function.
Coss, Djurdjica, Yeh, Debra M
core  

Molecular Engineering of the Helminth TGF‐β Mimetics, TGM1 and TGM4, Reveals a Novel Antagonist of TGF‐β Signaling in Fibroblasts

The FASEB Journal, Volume 40, Issue 7, 15 April 2026.
The helminth TGF‐β mimic TGM4 activates SMAD signaling in macrophages and T cells through canonical TGF‐β receptors and the CD44 co‐receptor, through Domains 1–5 (D1‐5). In fibroblasts, which express lower levels of CD44, TGM4 binds but does not transduce a signal; furthermore, it inhibits activation by agonist ligands such as TGF‐β itself, in a manner
Kyle T. Cunningham, Claire Ciancia, Tiffany Campion, Maarten van Dinther, Nadia Davis, Anja Duffy, Anna L. L. Heawood, Luke Power, Anna Sanders, Shashi P. Singh, Danielle J. Smyth, Elizabeth Thompson, Ruby White, Andrew P. Hinck, Peter ten Dijke, Rick M. Maizels   +15 more
wiley   +1 more source

The Activation of the Fibrodysplasia Ossificans Progressiva-Inducing ALK2-R206H Mutant Depends on the Distinct Homo-Oligomerization Patterns of ACVR2B and ACVR2A

Cells
Mutations in activin-like kinase 2 (ALK2), e.g., ALK2-R206H, induce aberrant signaling to SMAD1/5/8, leading to Fibrodysplasia Ossificans Progressiva (FOP). In spite of extensive studies, the underlying mechanism is still unclear. Here, we quantified the
Szabina Szófia Szilágyi, Wiktor Burdzinski, Jerome Jatzlau, Marcelo Ehrlich, Petra Knaus, Yoav I. Henis   +5 more
doaj   +1 more source

Activin A: its role and involvement in inflammatory diseases [PDF]

, 2015
Activin proteins are members of the transforming growth factor-β family. Activin A is involved in several biological responses including wound repair, cell death, proliferation and differentiation of many cell types.
Basir, Rusliza, Chuah, Yaw Kuang, Nordin, Norshariza, Talib, Herni, Tie, Tung Hing   +4 more
core  

Dynamics of the Mammalian Placental Metabolome in Placentogenesis and Embryonic Development

Advanced Science, Volume 13, Issue 19, 2 April 2026.
This study identifies three metabolic stages (E8.5, E9.5–10.5, E11.5–14.5) and two transition periods (E8.5–9.5, E10.5–11.5) in mouse placental development. NAD(H) emerges as a key dynamic metabolite that enhances embryonic growth through accelerated segmentation and increased proliferation of mouse embryonic stem cell (mESC)‐induced presomitic ...
Gang Chen, Zichen Liu, Mengyi Wei, Qian Li, Liang Wu, Kunyuan Yu, Yanhong Xu, Dainan Yu, Wenwu Ma, Hongmei Wang, Ng Shyh‐Chang, Jinglei Zhai   +11 more
wiley   +1 more source

Challenges and possible clinical applications of human embryonic stem cell research [PDF]

, 2012
Human embryonic stem cells (hESC) are harvested from the inner cell mass of the pre-implantation embryo and possess several unique characteristics. First, they are self-renewing, meaning they can grow indefinitely in an appropriate culture environment ...
De Sutter, Petra, Heindryckx, Björn, O'Leary, Thomas, Van der Jeught, Margot   +3 more
core   +1 more source