Results 131 to 140 of about 32,974 (249)

The Mediating Effect of Inflammatory Biomarkers in the Associations Between Sarcoidosis and Incident Ischemic Stroke: A Prospective Cohort Study

Brain and Behavior, Volume 16, Issue 4, April 2026.
Can invasive suckermouth catfish, Hypostomus plecostomus, be used as fishmeal? A potential solution to eradicate it from the Buriganga River, Bangladesh ABSTRACT Background and objective: Sarcoidosis, characterized by granulomatous inflammation across multiple systems, has an unclear connection with ischemic stroke and shared molecular pathways.
Zihong Bai, Wenming Shao, Xiaxuan Huang, Shanyuan Tan, Yitong Ling, Shiqi Yuan, Xinya Li, Jun Lyu   +7 more
wiley   +1 more source

GDF8 and activin A blockade protects against GLP-1–induced muscle loss while enhancing fat loss in obese male mice and non-human primates

Nature Communications
Glucagon-like peptide-1 receptor agonists act via appetite suppression and caloric restriction. These treatments can result in significant muscle loss, likely due to evolutionary mechanisms protecting against food scarcity as muscle is a major energy ...
Jason W. Mastaitis, Daniel Gomez, José G. Raya, Diana Li, Soo Min, Michael Stec, Sandra Kleiner, Toya McWilliams, Judith Y. Altarejos, Andrew J. Murphy, George D. Yancopoulos, Mark W. Sleeman   +11 more
doaj   +1 more source

Adventitial Niches, Complement and Inflammation in Pulmonary Vascular Disease: Current Status and Future Directions

Comprehensive Physiology, Volume 16, Issue 2, April 2026.
Local complement production by pulmonary artery adventitial fibroblasts, activated intracellularly by CFD and CFB and extracellularly by GZMK+ CD8 T cells, and its secretion in soluble form and within EVs promotes macrophage and T cell chemotaxis and activation.
Hui Zhang, Ram Raj Prasad, Sushil Kumar, Min Li, Dallas Jones, Cheng‐Jun Hu, Claudia Mickael, Yen‐Rei Yu, Rubin M. Tuder, Kurt R. Stenmark   +9 more
wiley   +1 more source

The Importance of Liver‐Lung Communication in Pulmonary Vascular Diseases

Comprehensive Physiology, Volume 16, Issue 2, April 2026.
Schematic depicting the key drivers of liver‐lung communication in pulmonary vascular diseases, including hepatic dysfunction, portosystemic shunting, and gut microbial dysbiosis, which together drive pulmonary vascular remodeling. ABSTRACT In normal health, the liver and lungs enjoy a close anatomic, physiologic, and functional relationship.
Navneet Singh, Hilary M. DuBrock, Sasha Z. Prisco, Zhiyu Dai, Qi Zheng, Michael B. Fallon, Thenappan Thenappan, Corey E. Ventetuolo, Arun Jose   +8 more
wiley   +1 more source

Annual Banned‐Substance Review 18th Edition—Analytical Approaches in Human Sports Drug Testing 2024/2025

Drug Testing and Analysis, Volume 18, Issue 4, Page 458-482, April 2026.
New insights into drug metabolism, distribution, elimination, and detection assays for drugs and methods of sports doping published between 2024 and 2025 are critically reviewed and evaluated in context with the Prohibited List 2025 as established by the World Anti‐Doping Agency.
Mario Thevis, Tiia Kuuranne, Hans Geyer
wiley   +1 more source

A Systematic Review and User Reference of Phenotypic and Molecular Characteristics of Dexamethasone‐Mediated C2C12 Muscle Atrophy

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 2, April 2026.
ABSTRACT Background Skeletal muscle is a vital part of human physiology and is responsible for numerous essential functions. Not surprisingly, the loss of skeletal muscle mass and function is common in several pathologies including atrophy and sarcopenia, which profoundly impact quality of life of those afflicted.
Alexa J. Klein, Roger A. Vaughan
wiley   +1 more source

Distinct Proteomic Signatures Driving Progression of Sarcopenia: A Longitudinal Multicohort Study

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 2, April 2026.
ABSTRACT Background Sarcopenia is an age‐related condition characterized by progressive muscle mass, strength and physical performance declines, contributing to frailty and adverse health outcomes. Despite increasing interest in molecular biomarkers, longitudinal data with external validation are limited.
Sung Hye Kong, Ok Hee Jeon, Ji Yeon Kim, Miji Kim, Jinhee Kim, Seung Shin Park, Hak Chul Chang, Chang Won Won, Dohyun Han   +8 more
wiley   +1 more source

Inhibition of N‐Terminal Acetyltransferase C Mitigates Endoplasmic Reticulum Stress–Mediated Muscle Atrophy in Cancer Cachexia

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 2, April 2026.
ABSTRACT Background Cancer cachexia is a complex syndrome marked by weight loss and muscle wasting, significantly impacting patient quality of life and survival. Mechanistically, it is characterized by suppressed protein synthesis and enhanced muscle catabolism, with the role of endoplasmic reticulum (ER) stress and unfolded protein response (UPR ...
Yusaku Kaneko, Tomohiro Hino, Shunta Taminishi, Yayoi Matoba, Daisuke Motooka, Atsushi Hoshino, Satoaki Matoba   +6 more
wiley   +1 more source

UBE3A Inhibits Trophoblast Cell Migration and Invasion by Promoting ITGB1 Degradation and Affecting PI3K/AKT Signaling

The Kaohsiung Journal of Medical Sciences, Volume 42, Issue 4, April 2026.
ABSTRACT Preeclampsia (PE) is an obstetric disease that is characterized by reduced migration and invasion of placental trophoblast cells. Here, the effects of the E3 ubiquitin ligase UBE3A on the migration and invasion of trophoblast cells were evaluated.
Xiu‐Jun Li, Ning Wang, Fan Jiang, Jie‐Cheng Yang, Yan‐Yun Wang, Kun Wang   +5 more
wiley   +1 more source

Combined detection of inhibitors of the activin receptor signaling pathways (IASPs) by means of LC-HRMS/MS for human doping control

Scientific Reports
Members of the transforming growth factor beta superfamily such as myostatin, activin A, and GDF-11, are dimeric cytokines signaling through activin receptors.
Panagiotis Sakellariou, Katja Walpurgis, Andreas Thomas, Alexandre Marchand, Geoff Miller, Frank Dellanna, Mario Thevis   +6 more
doaj   +1 more source