Results 201 to 210 of about 32,974 (249)

Anti-activin treatment increases T cell infiltration in breast and pancreatic tumours and promotes survival in a SMAD4-null mouse pancreatic cancer model

McCluney S, Park D, Miller DS, Mehić M, Bloxham RD, De Vries E, Wang X, Boeing S, D’Antonio L, Wieteska Ł, Pyeatt G, Strohbuecker S, Chakravarty P, Maia De Oliveira T, Wilkinson RW, Hyvönen M, Hunt J, Hill CS.   +17 more
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Activin Receptor Inhibitors—Dalantercept

Current Oncology Reports, 2015
Development of anti-angiogenic therapy including the vascular endothelial growth factor (VEGF) antibodies and VEGF-tyrosine kinase receptors has been a major landmark in cancer therapy leading improvement in survival in several cancers. While anti-angiogenic therapy is effective in some settings, resistance often develops owing to evasive, alternative ...
Shilpa, Gupta, David, Gill, Sumanta K, Pal, Neeraj, Agarwal   +3 more
openaire   +2 more sources

Activin A and Activin Receptors in Thyroid Cancer

Thyroid, 2001
Proliferation is controlled by a network of mitogenic and growth inhibitory factors. Transforming growth factor-beta1 (TGF-beta1) and activin A are the most important growth inhibitors of benign follicular epithelial cells of the human thyroid. The effects of these substances on malignant primary thyrocytes are not known.
K M, Schulte, C, Jonas, R, Krebs, H D, Röher   +3 more
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Activin Receptor Modulation

2018
Conventional treatment regimen of lower-risk MDS with erythropoiesis-stimulating agents often fails to induce sustained erythroid improvement in these patients that frequently harbor defects in late-stage erythroblasts downstream of erythropoietin action.
Anna Mies, Amit Verma, Uwe Platzbecker
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Activin, Activin-Binding Protein (Follistatin) and Activin Receptor

1993
The principal regulators of the pituitary gonadotropins LH and FSH in mammals are the gonadotropin-releasing hormone (GnRH) from the hypothalamus and the gonadal steroids.
Hiromu Sugino, Takanori Nakamura, Kishiko Sugino, Koiti Titani   +3 more
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Localization of an activin/activin receptor system in the porcine ovary

Molecular Reproduction and Development, 2001
AbstractThe aim of this study was to locate a possible activin/activin receptor system within porcine ovaries containing functional corpora lutea. In situ hybridization was used to assess the gene expression of βA‐ and βB‐activin subunits, and immunohistochemical studies were done to detect activin‐A protein and activin receptor type II.
van den Hurk, R., van der Pavert, S.A.
openaire   +3 more sources

Inactivation of activin-dependent transcription by kinase-deficient activin receptors.

Endocrinology, 1995
Activin, a member of the transforming growth factor-beta superfamily, binds to two classes of cell surface receptors. These receptors, designated type I and type II, are structurally related members of transmembrane serine kinase superfamily. Antibodies specific for either type I or type II activin receptor can coprecipitate complexes containing both ...
K, Tsuchida, J M, Vaughan, E, Wiater, D, Gaddy-Kurten, W W, Vale   +4 more
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Activin and Activin Receptor Expression Changes in Liver Regeneration in Rat

Journal of Surgical Research, 2005
This study aimed to investigate regulatory mechanisms of hepatocyte proliferation by comparing liver regeneration of the remnant lobe after 70% partial hepatectomy (PH) and portal vein branch ligation (PBL) in rat.Expressions of activins betaA, betaC, and betaE and their receptors were investigated after PH and PBL.
Kazuhito, Takamura, Kunihiro, Tsuchida, Hidenori, Miyake, Seiki, Tashiro, Hiromu, Sugino   +4 more
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Bovine preantral follicles and activin: Immunohistochemistry for activin and activin receptor and the effect of bovine activin a in vitro

Theriogenology, 1997
Activin was originally isolated from follicular fluid as a factor stimulating FSH from the pituitary. Recent studies also suggest a local role for activin in the development of preantral and early antral follicles. In the present study, activin and activin receptor immunoreactivity are shown in oocyte and granulosa cells of bovine preantral follicles ...
S C, Hulshof, J R, Figueiredo, J F, Beckers, M M, Bevers, H, Vanderstichele, R, van den Hurk   +5 more
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Activin receptor signaling.

Growth factors (Chur, Switzerland), 2005
Activin is a member of the TGF-beta superfamily and has various effects on diverse biological systems. Activins initiate their cellular responses by binding to their receptors with intrinsic serine/threonine kinase activity and activation of specific downstream intracellular effectors termed Smad proteins.
Yumiko, Abe, Takashi, Minegishi, Peter C K, Leung   +2 more
openaire   +1 more source