Results 211 to 220 of about 32,974 (249)

Truncated Activin Type II Receptors Inhibit Activin Bioactivity by the Formation of Heteromeric Complexes with Activin Type I Receptors

Experimental Cell Research, 1996
Truncated activin type II receptors have been reported to inhibit activin receptor signaling in Xenopus embryos, although the mechanism of action for this effect has not been fully understood. In the present study we demonstrate that in P19 embryonal carcinoma cells both the induction of the activin responsive 3TP-lux reporter construct and the ...
de Winter, J. P., de Vries, C. J., van Achterberg, T. A., Ameerun, R. F., Feijen, A., Sugino, H., de Waele, P., Huylebroeck, D., Verschueren, K., van den Eijden-van Raaij, A. J.   +9 more
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Activins and their receptors in female reproduction

Biochemistry and Cell Biology, 2000
Activins are growth and differentiation factors belonging to the transforming growth factor-β superfamily. They are dimeric proteins consisting of two inhibin β subunits. The structure of activins is highly conserved during vertebrate evolution. Activins signal through type I and type II receptor proteins, both of which are serine/threonine kinases ...
C, Peng, S T, Mukai
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Gene expression of activin, activin receptors, and follistatin in intestinal epithelial cells

American Journal of Physiology-Gastrointestinal and Liver Physiology, 2000
Gene expression of activin, activin receptors, and follistatin was investigated in vivo and in vitro using semiquantitative RT-PCR in intestinal epithelial cells. Rat jejunum and the intestinal epithelial cell line IEC-6 expressed mRNA encoding the βA-subunit of activin, α-subunit of inhibin, activin receptors IB and IIA, and follistatin. An epithelial
K, Sonoyama, S, Rutatip, T, Kasai
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EXPRESSION OF ACTIVIN AND ACTIVIN RECEPTORS IN PC3 HUMAN PROSTATIC-CANCER CELLS

International Journal of Oncology, 1995
PC3 human prostatic cancer cells, which are androgen-independent and hormone-nonresponsive, were used to examine the possible presence and expression of activin and its receptors in this cell line because activin is a member of transforming growth factor beta (TGF beta) superfamily which has been found to have growth-inhibitory activity.
S, Ying, Z, Zhang, W, Xing
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Different phenotypes for mice deficient in either activins or activin receptor type II

Nature, 1995
Activins are believed to initiate a signal transduction cascade by binding to serine/threonine kinase receptors types I and II. Activins bind to several different receptors in vitro, but the significance of this interaction in vivo has not been confirmed.
M M, Matzuk, T R, Kumar, A, Bradley
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Inhibin/ activin subunits and activin receptor are co-expressed in Leydig tumor cells

Molecular and Cellular Endocrinology, 1993
The expression of genes encoding inhibin/activin subunits and activin receptor was examined in four cultured Leydig tumor cells (MA-10, I-10, R2C, and LC-540). Inhibin alpha-subunit gene was highly expressed in Leydig tumor cell lines except LC-540. Both inhibin beta-A- and beta-B-subunit mRNAs were present in low levels. The 6.5-kb beta-A-subunit mRNA
C L, Chen, O P, Pignataro, Z M, Feng
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EXPRESSION OF ACTIVIN AND ACTIVIN RECEPTORS IN HUMAN PROSTATIC-CARCINOMA CELL-LINE DU145

International Journal of Oncology, 1995
The purpose of this study was to determine whether DU145, a human prostate cancer cell line: (a) transcribes mRNAs coding for beta A- and beta B-subunits of activin, a member of transforming growth factor beta (TGF beta) superfamily, and activin receptors I, II, and IIB; and (b) produces activin proteins.
B, Furst, Z, Zhang, S, Ying
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Activins and the Receptor Serine Kinase Superfamily

1995
Publisher Summary Inhibins and activins were discovered by virtue of their effects on the gonadotropic cells of the anterior pituitary. Inhibin/activin subunits and their mRNAs have been detected in many tissues, including the ovary, testis, placenta, pituitary, central nervous system (CNS), adrenal, and bone marrow.
D, Gaddy-Kurten, K, Tsuchida, W, Vale
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[Activin and activin receptors in related gynecologic and obstetric diseases].

Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences, 2011
Activin is a member of the transforming growth factor-beta (TGF-beta) superfamily that result from the assembly of disulphide-linked betaA and betaB subunits. Activin receptors are transmembrane proteins and activin fulfils the biological function through the signal transduction of the receptor system.
Hongyun, Li, Fengying, Huang
openaire   +1 more source

Integrative oncology: Addressing the global challenges of cancer prevention and treatment

Ca-A Cancer Journal for Clinicians, 2022
Jun J Mao,, Msce, Lorenzo Cohen, Karen M Mustian   +2 more
exaly