In this post hoc analysis of the phase 3 SIMPLIFY‐1 and MOMENTUM trials, the number of patients with baseline hemoglobin < 10 g/dL who achieved hemoglobin ≥ 10 g/dL by week 24 with momelotinib, as well as the time to achievement, were evaluated. Patients who were JAK inhibitor naive and/or had moderate anemia were more likely and faster to achieve this
Francesca Palandri +11 more
wiley +1 more source
Sotatercept-related peripheral microvascular alterations in systemic sclerosis-associated pulmonary arterial hypertension: insights from nailfold capillaroscopy. [PDF]
Segawa Y +14 more
europepmc +1 more source
Abstract Objectives/Background Cluster headache (CH) has historically been considered a male‐dominated disorder, suggesting a role for androgens in its pathophysiology. We aimed to evaluate hormone profiles and symptoms of androgen deficiency in CH.
Willemijn C. Naber +7 more
wiley +1 more source
Lipoprotein(a), Endothelial Dysfunction and Cardiovascular Disease
ABSTRACT Lipoprotein(a) (Lp(a)) is a particle similar to low‐density lipoprotein cholesterol and is associated with apolipoprotein (A). High Lp(a) levels are a genetic, independent risk factor for atherosclerotic cardiovascular disease (ASCVD). Endothelial cells, which form the continuous lining of the cardiovascular system, are crucial for vascular ...
Xianghui Zhou +5 more
wiley +1 more source
Integrative follicular fluid biomarkers for oocyte competence and IVF outcomes: from molecular networks to multianalyte panels. [PDF]
Chen CY +9 more
europepmc +1 more source
BMP‐3 is synthesized as a proprotein that is cleaved by furin/proprotein convertases (PC) to release the biologically active mature ligand. Although never experimentally verified, the BMP‐3 ligand is recorded as C‐terminal Q363‐R472 (110 amino acids) approximately 16 kDa.
David E. Phelan +4 more
wiley +1 more source
Activin Signaling Inhibitors in Pulmonary Hypertension: A State-of-the-Art Review. [PDF]
Rajagopal S +10 more
europepmc +1 more source
NFкB pathway suppression as a key driver of pacritinib response in high‐risk myelofibrosis
British Journal of Haematology, Volume 209, Issue 5, Page 2331-2334, November 2026.
R. Van Dijck +8 more
wiley +1 more source
Disentangling Pulmonary Vascular Phenotypes in Group 2 Pulmonary Hypertension Using Bioactive Lipid Profiling. [PDF]
Garry JD, Brittain EL.
europepmc +1 more source
Sotatercept as a Treatment for Pulmonary Hypertension Associated With Connective Tissue Disease and ILD. [PDF]
Vargas-Ursúa F +2 more
europepmc +1 more source

