Results 61 to 70 of about 425,946 (294)

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Functional disability among the older adult population in Kedah, Malaysia

Clinical Epidemiology and Global Health
Background: Functional disability, defined as acquired difficulty in performing basic daily tasks or more complex tasks needed for independent living.
Ganesh Pandian Balasubramanian, Saraswathi Simansalam, Sireesha Paruchuri, Lydia Lu Qing Yi, Jun Hao Chui   +4 more
doaj   +1 more source

Idosos não japoneses, japoneses e descendentes de japoneses no Estudo Saúde, Bem-Estar e Envelhecimento: condições funcionais e de saúde

Revista Brasileira de Epidemiologia, 2019
RESUMO: Introdução: A cidade de São Paulo conta com a maior comunidade de descendentes japoneses fora do Japão. Objetivos: Comparar as condições demográficas, econômicas, funcionais e de saúde de idosos não japoneses, japoneses e descendentes de ...
Tamara Nogueira Petroni, Daniella Pires Nunes, Yeda Aparecida de Oliveira Duarte, Helena Akemi Wada Watanabe, Maria Lúcia Lebrão   +4 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Evaluation of activities and instrumental activities of daily living and correlated factors of traumatic brain injury patients in Vietnam

Scientific Reports
Traumatic brain injury (TBI) is among the leading causes of death in Vietnam. Survivors of TBI suffer from functional and cognitive deficits. Understanding that Activities of Daily Living (ADLs) and Instrumental Activities of Daily Living (IADLs) are ...
Anh Thuy Hoang, Tung Hoang Tran, Hai Minh Vu, Hoa Thi Do, Thuc Minh Thi Vu, Linh Gia Vu, Cuong Tat Nguyen, Huyen Phuc Do, Carl A. Latkin, Roger C. M. Ho, Cyrus S. H. Ho   +10 more
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Verifying Properties of Activities of Daily Living

The monitoring of Activities of Daily Living (ADLs) for older adults can support their well-being since deviations in behaviour may indicate cognitive or physical decline, and reduced quality-of-life. In this work we present a new methodology that combines the spatial context with the observed behaviour of the person to enable a rigorous analysis of ...
Ricardo Contreras, Filip Smola, Jiawei Zheng, Jane Hillston, Jacques D. Fleuriot   +4 more
openaire   +2 more sources

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source