Results 71 to 80 of about 1,947,838 (286)

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Functional disability among the older adult population in Kedah, Malaysia

Clinical Epidemiology and Global Health
Background: Functional disability, defined as acquired difficulty in performing basic daily tasks or more complex tasks needed for independent living.
Ganesh Pandian Balasubramanian, Saraswathi Simansalam, Sireesha Paruchuri, Lydia Lu Qing Yi, Jun Hao Chui   +4 more
doaj   +1 more source

A randomized trial of a multicomponent home intervention to reduce functional difficulties in older adults [PDF]

, 2006
OBJECTIVES: To test the efficacy of a multicomponent intervention to reduce functional difficulties, fear of falling, and home hazards and enhance self-efficacy and adaptive coping in older adults with chronic conditions. DESIGN: A prospective, two-group,
Arfken, Bandura, Bradley, Bruce, Cohen, Corcoran, Cumming, Elkan, Ettinger, Ferrucci, Folstein, Fried, Gill, Gill, Gill, Gitlin, Gitlin, Gitlin, Greiner, Hinojosa, Hortobagyi, Kravitz, Kressig, Lawton, Lorig, Mann, Manton, Marshall, Morris, Naik, Powell, Radloff, Rich, Schulz, Shumway-Cook, Spillman, Stuck, Tennstedt, Tinetti, Tinetti, Tinetti, Van Haastregt, Verbrugge, Vladeck, Wrosch   +44 more
core   +2 more sources

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Evaluation of activities and instrumental activities of daily living and correlated factors of traumatic brain injury patients in Vietnam

Scientific Reports
Traumatic brain injury (TBI) is among the leading causes of death in Vietnam. Survivors of TBI suffer from functional and cognitive deficits. Understanding that Activities of Daily Living (ADLs) and Instrumental Activities of Daily Living (IADLs) are ...
Anh Thuy Hoang, Tung Hoang Tran, Hai Minh Vu, Hoa Thi Do, Thuc Minh Thi Vu, Linh Gia Vu, Cuong Tat Nguyen, Huyen Phuc Do, Carl A. Latkin, Roger C. M. Ho, Cyrus S. H. Ho   +10 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Biomechanics of stair descent in older adults [PDF]

, 2005
Negotiating stairs is one of the most difficult activities of daily living faced by older adults. Many researchers have studied the cardiovascular and musculoskeletal demands of stair ascent but there is little research on the biomechanics of stair ...
Hood, Victoria, Nicol, Alexander
core  

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Does repetitive task training improve functional activity after stroke? A Cochrane systematic review and meta-analysis. [PDF]

, 2010
Repetitive task training resulted in modest improvement across a range of lower limb outcome measures, but not upper limb outcome measures. Training may be sufficient to have a small impact on activities of daily living.
Forster, Anne, French, Beverley, Langhorne, Peter, Leathley, Michael John, McAdam, Joanna, Price, Christopher, Sutton, Chris J, Thomas, Lois Helene, Walker, Andrew, Watkins, Caroline Leigh   +9 more
core   +2 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source