Results 221 to 230 of about 69,826,182 (251)

A Machine Vision‐Guided Microphysiological Platform With Automated Microfluidics Enables Longitudinal Biomarker Monitoring and Emulation of Translationally Relevant Exposure Scenarios

Advanced Science, EarlyView.
A pneumatically actuated multi‐tissue microphysiological system is integrated with AI‐based machine vision and automatic sampling and replenishment systems. The platform allows for the emulation of translationally relevant long‐term pharmacokinetic exposure scenarios for multiple weeks while enabling longitudinal monitoring of response biomarkers ...
Jibbe Keulen, Yi Zhong, Laura Dangel, Sonia Youhanna, Reza Zandi Shafagh, Jinhye Ryu, Domnica‐Gabriela Gurau, Mathias Haag, Thomas E. Mürdter, Yingxin Liang, Iro Beligiani, Nicole Ziegler, Sabine Willems, Nayere Taebnia, Wouter van der Wijngaart, Volker M. Lauschke   +15 more
wiley   +1 more source

Trends in the etiology of acute insult and underlying chronic liver disease in patients with acute-on-chronic liver failure: A retrospective study in Southwest China (2020-2023). [PDF]

Medicine (Baltimore)
Fang Y, Dai H, Li Q, Wang D, Liu J, Liu Y.   +5 more
europepmc   +1 more source

RPLP2 Mediates the Beneficial Effects of Exercise on Stress Resistance Through Muscle–Brain Communication

Advanced Science, EarlyView.
A novel exercise‐inducible myokine acidic ribosomal protein P2 (RPLP2), initially identified from human trials, is presented here, whose circulating levels negatively correlate with clinical anxiety severity. Muscle‐derived RPLP2 enhances hippocampal ribosomal assembly and adult neurogenesis to rescue stress‐induced anxiety deficits.
Peiyu Luo, Wei Wu, Huan Peng, Dan He, Yuxi Guo, Boyue Zhao, Xiaodan Wang, Li Ma, Yuhang Qin, Yifang Zhai, Lixia Zhuo, Ying Zhang, Yijie Guo, Linlin Jing, Fangyao Chen, Erfei Zhang, Wei Wang, Xiancang Ma, Yan Li   +18 more
wiley   +1 more source

Pre-liver transplant assessment of patients with acute-on-chronic liver failure: An international survey. [PDF]

JHEP Rep
Bellec C, Augé A, L'Hermite S, Moirand R, Abergel A, Amstrong M, Antonini T, Anty R, Khaldi M, Baron A, Bensenane-Oussalah M, Bernal W, Bureau C, Carbonell N, Cadranel JF, Cardoso F, Carrier P, Coilly A, Conde I, Conti F, Bonadona A, Crespo G, Murad SD, Dharancy S, Duvoux C, Engelmann C, Faitot F, Francoz C, Garioud A, Gerolami R, Gigante E, Goria O, Gustot T, Hogan B, Lagin L, Lannes A, Latournerie M, de Ledinghen V, Magini G, Mateo M, Maurin A, Merli M, Meszaros M, Pageaux GP, Perignon C, Perricone G, Praktiknjo M, Reboux N, Reiberger T, Rolle V, Rosa I, Sarba R, Wartel F, Weil DV, Zanetto A, Elkrief L, Artru F.   +56 more
europepmc   +1 more source

EphB1‐Mediated Transient Blood‐Brain Barrier Opening Facilitates a Ferritin‐Based Nanotherapeutic for Alzheimer's Disease

Advanced Science, EarlyView.
We constructed a brain‐targeted AFn‐DPZ nanodrug delivery system and identified EphB1 as its receptor on the blood‐brain barrier (BBB). This system facilitates drug transport across the BBB and thereby ameliorates cognitive impairment in Alzheimer's disease.
Shilin Wen, Jingjing Gao, Zhixian Wang, Qiumin Ma, Xiao‐Ling Xu, Jianer Chen   +5 more
wiley   +1 more source

Prognostic Role of Acute-on-Chronic Liver Failure in Acute Variceal Bleeding: A Multicenter Retrospective Study in Australia. [PDF]

Gut Liver
Kurup R, Dao HHH, Lin PY, Read S, Ma WS, George J, Ahlenstiel G.   +6 more
europepmc   +1 more source

Organ failure-based clinical classification at onset of acute-on-chronic liver failure: a prospective multicenter cohort study. [PDF]

Sci Rep
Xu M, Wu Y, Wang W, Yang Y, Zou H, Kong M, Wang X, Duan Z, Xin S, You S, Li J, Han T, Xiang X, Chen Y.   +13 more
europepmc   +1 more source

Dynamic Changes in C-reactive Protein and Procalcitonin as Predictors of 28-day Mortality in Acute-on-chronic Liver Failure: A Prospective Observational Study from Northeast India. [PDF]

Indian J Crit Care Med
Saravanamuthu PK, Das AK, Rajkakati R, Sonowal A.   +3 more
europepmc   +1 more source

Sepsis in end-stage liver disease and acute-on-chronic liver failure: pathophysiology, diagnostic challenges, and pharmacological management. [PDF]

Front Pharmacol
Belfiore J, Taddei R, Suardi LR.
europepmc   +1 more source

Prospective study of pharmacokinetics of isavuconazole in critically ill patients undergoing continuous hemodialysis with and without acute-on-chronic liver failure. [PDF]

Ann Intensive Care
Behrens E, König C, Jarczak D, Martens-Lobenhoffer J, Bode-Böger SM, Kluge S, Wicha SG, Fuhrmann V, Grensemann J.   +8 more
europepmc   +1 more source