Results 81 to 90 of about 53,571 (225)

In vitro activity of omadacycline against bacterial isolates from bone/joint infections and rare pathogens in the SENTRY antimicrobial surveillance program (2015–2023)

Journal of Global Antimicrobial Resistance
Objectives: Omadacycline is an aminomethylcycline (tetracycline class) antibacterial approved by the United States Food and Drug Administration (2018) for treatment of adults with acute bacterial skin and skin structure infection (ABSSSI) and community ...
Michael D. Huband, Paul R. Rhomberg, Kelley A. Fedler, Christopher Blankers, Diane Anastasiou, Alisa W. Serio, Mariana Castanheira   +6 more
doaj   +1 more source

PEAR1 Promotes Glucose Metabolism Reprogramming in Sepsis‐Associated Acute Lung Injury via AARS1‐Mediated HIF‐1α Lactylation

Advanced Science, EarlyView.
This study revealed that a PEAR1/HIF‐1α/ glycolysis/lactate/H3K18la positive feedback loop in PMVECs that drives the development of S‐ALI. Mechanistically, PEAR1 mediates the binding of HIF‐1α to AARS1, leading to the lactylation of HIF‐1α, the primary lactylation site of which is K172.
Shuai Li, Zongqing Lu, Pu Fang, Qingqing Pang, Xianghui Wu, Bo Wang, Min Liang, Jingjing Pan, Haobo Kong, Haijian Cai, Juanjuan Li, Jiaying Kang, Dongsheng Wang, Dunling Xia, Mengmeng Xu, Qinghai You   +15 more
wiley   +1 more source

Omadacycline Oral Dosing and Pharmacokinetics in Community-Acquired Bacterial Pneumonia and Acute Bacterial Skin and Skin Structure Infection. [PDF]

Clin Drug Investig, 2022
Leviton IM, Amodio-Groton M.
europepmc   +1 more source

Critical appraisal of ceftaroline in the management of community-acquired bacterial pneumonia and skin infections

Therapeutics and Clinical Risk Management, 2012
Julian J Goodman, Stanley I MartinDivision of Infectious Diseases, The Ohio State University, Columbus, OH, USAAbstract: Ceftaroline is a novel broad-spectrum cephalosporin ß-lactam antibiotic with activity against methicillin-resistant ...
Goodman JJ, Martin SI
doaj  

Harmonizing Rigidity and Flexibility: Embedding COF Quantum Dots Into Extracellular Matrix Gel as Carbon Monoxide Depot for Acoustically Triggered Time‐Programmable Anti‐Infective Therapy

Advanced Science, EarlyView.
A rigid‑flexible integrated CO depot is engineered by embedding rigid COFQDs into a flexible ECM gel network. The rigid framework enables high‑capacity CO storage and sonodynamic bacterial killing, while the flexible ECM gel controls sustained CO release, collectively eradicating multidrug‑resistant infection and promoting scarless healing.
Baohong Sun, Fang Han, Chunxiao Zhu, Zhiyuan Yang, Haoru Wang, Jinpei Mei, Jie Chen, Jingwen Zhu, Zihan Bo, Taju Wu, Xiaogang Zhou, Tao Ma, Yutian Su, Youhui Lin   +13 more
wiley   +1 more source

Daptomycin approved in Japan for the treatment of methicillin-resistant Staphylococcus aureus

Therapeutics and Clinical Risk Management, 2012
Mao Hagihara1, Takumi Umemura1, Takeshi Mori1,2, Hiroshige Mikamo11Department of Infection Control and Prevention, Aichi Medical University School of Medicine, Nagakute, Aichi, Japan; 2Division of Pharmaceutical Science, Faculty of Pharmacy, Meijo ...
Mori T, Umemura T, Hagihara M, Mikamo H
doaj  

Preclinical model of Echinacea-functionalized silk fibroin–chitosan transparent membranes with enhanced hair follicle regeneration and antibacterial properties for wound healing

Frontiers in Bioengineering and Biotechnology
IntroductionSkin serves as a crucial barrier that separates the human body from the external environment. Its complex structure can make it susceptible to microbial infection and bleeding, leading to poor wound healing.
Zhili Wei, Lunan Yang, Sining Feng, Bowen Zheng, Xingliang Xiong, Yiming Zhao   +5 more
doaj   +1 more source

Microbiology of acute bacterial skin and skin-structure infections in Greece: A proposed clinical prediction score for the causative pathogen

, 2019
Although clinical definitions of acute bacterial skin and skin-structure infection (ABSSSI) are now well established, guidance of the prediction of likely pathogens based on evidence is missing.
Kontopoulou, T., Adamis, G., Griffiths, D., Akinosoglou, K., MacGowan, A., Voloudakis, N., Nodaras, C., Bayram, C., Toutouzas, K.G., Kokkinakis, E., Gogos, C., Kaziani, K., Kritselis, I., Tsironis, C., Koutelidakis, I.M., Chrisanthakopoulou, M., Kranidioti, E., Pantazi, A., O'Hare, M., Christaki, E., Gogkou, A., Lada, M., Vittoros, V., Giamarellos-Bourboulis, E.J., Tziolos, N., Tsoutsos, D., Kotsaki, A., Karkamanis, A., Alexiou, Z., Sambatakou, H., Bristianou, M., Sympardi, S., Mousoulis, G., Fillas, I.   +33 more
core   +1 more source

Modulating Calcium Homeostasis via a Biomimetic Scaffold to Rescue Diabetic Ischemic Wounds

Advanced Science, EarlyView.
This strategy addresses impaired microcirculation and loss of extracellular matrix (ECM) guidance in diabetic wound healing. Musc@CP, a nanofibrous dressing combining an ECM‐mimetic chitosan‐pullulan scaffold with muscone, enhances perfusion by attenuating intracellular Ca2+ overload‐associated endothelial dysfunction.
Xiang Zheng, Mingmei Li, Jianjun Jiang, Yongchao Wang, Yaru Jia, Weilun Sun, Yi Yao, Pengli Gao, Linhua Zhang, Qi Guo, Guang Jia, Xing‐Jie Liang, Dunwan Zhu, Jinchao Zhang, Fangzhou Li   +14 more
wiley   +1 more source

Design, development and optimization of tedizolid phosphate carbopol based emulgel for skin drug delivery

Journal of Applied Pharmaceutical Research
Background: Tedizolid phosphate (TZP) is effective against Gram-positive pathogens. It is used most widely in skin infections. Currently, there is no development of emulgels with this novel antibiotic molecule.
Madhavi Nimmathota, Sravani Chokkarapu, Akshitha Tirumali, Umamaheshwara Rao Vattikuti   +3 more
doaj   +1 more source